Results 81 to 90 of about 29,730 (229)
Investigation of MLKL ubiquitylation during necroptosis
, 2019 © 2019 Zikou LiuNecroptosis is one type of caspase 8-independent programmed cell death. Mixed lineage kinase domain-like (MLKL) is the essential terminal effector in the necroptosis signalling pathway.
Liu, Zikou
core +1 more source
Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer
Medicinal Research Reviews, EarlyView.ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek +3 more
wiley +1 more source
Ubiquitylation and control of renal na+ balance and blood pressure.
, 2014 Ubiquitylation is crucial for regulating numerous cellular functions. In the kidney, ubiquitylation regulates the epithelial Na(+) channel ENaC. The importance of this process is highlighted in Liddle's syndrome, where mutations interfere with ENaC ...
Staub, O., Ronzaud, C.
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Construction of a robust sepsis prognostic classifier based on E3 ubiquitin ligase-related genes
Frontiers in Molecular BiosciencesSepsis is a life-threatening disease with high mortality and one of the leading causes of death worldwide. Although studies have shown that ubiquitylation is closely related to the occurrence and development of sepsis, the prognostic and diagnostic value
Haiyan Xue +4 more
doaj +1 more source
CD47 promotes myeloma cell growth through JAK–STAT3/MYC signalling and is targetable by ruxolitinib
British Journal of Haematology, EarlyView.Summary Cluster of differentiation 47 (CD47), a ‘don't eat me’ immune checkpoint receptor, is frequently overexpressed on multiple myeloma (MM) cells and contributes to immune evasion. While its immune regulatory function is well established, the intrinsic oncogenic role of CD47 remains poorly understood.
Omar Faruq +6 more
wiley +1 more source
The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment
British Journal of Pharmacology, EarlyView.Morphine activation of μ receptors causes tolerance through c‐Src activation and β‐arrestin2 recruitment. c‐Src inhibition or degradation reduces β‐arrestin2 recruitment, μ receptor endocytosis, while causing receptor upregulation, all likely contributing to reduced morphine tolerance.
Samuel Singleton +6 more
wiley +1 more source
Herc4 controls Sav stability and ubiquitylation.
, 2015 (A) Sav binds to Herc4. Myc-tagged Sav was immunoprecipitated using a Myc antibody and bound Herc4-Flag protein detected using Flag antibody. Myc-tagged Drosophila Rep3 was used as control. (B) herc4 RNAi stabilises Sav protein levels.
Ieva Gailite (763016) +3 more
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Mapping the substrate landscape of protein phosphatase 2A catalytic subunit PPP2CA
iScienceSummary: Protein phosphatase 2A (PP2A) is an essential Ser/Thr phosphatase. The PP2A holoenzyme complex comprises a scaffolding (A), regulatory (B), and catalytic (C) subunit, with PPP2CA being the principal catalytic subunit.
Abigail Brewer +5 more
doaj +1 more source