Results 81 to 90 of about 28,143 (190)
Advances in characterizing ubiquitylation sites by mass spectrometry
, 2013 The attachment of one or more ubiquitin moieties to proteins plays a central regulatory mechanism in eukaryotic cells. Protein ubiquitylation regulates numerous cellular processes, including protein degradation, signal transduction, DNA repair and cell ...
Sylvestersen, K.B. +2 more
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ChemBioChem, Volume 27, Issue 11, 15 June 2026.Polycomb (Pc), a core component of Polycomb Repressive Complex 1 (PRC1), is largely intrinsically disordered yet forms buffer‐ and concentration‐dependent higher‐order assemblies. Integrative biophysical analysis and cryo‐electron microscopy reveal dynamic, heterogeneous oligomers, whereas AlphaFold modeling suggests that structural organization is ...
Maria Zahid +4 more
wiley +1 more source
UbiProt: a database of ubiquitylated proteins
BMC Bioinformatics, 2007 Background Post-translational protein modification with ubiquitin, or ubiquitylation, is one of the hottest topics in a modern biology due to a dramatic impact on diverse metabolic pathways and involvement in pathogenesis of severe human diseases.
Kondratieva Ekaterina V +5 more
doaj +1 more source
Assessing Ubiquitylation of Individual Proteins Using Xenopus Extract Systems.
, 2018 Xenopus extract systems have been used to study ubiquitylation of proteins, and to uncover some of the fundamental processes of the ubiquitylation pathway itself. They provide a simple, quick, and robust method for studying ubiquitylation.
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Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, Volume 600, Issue 11, Page 1638-1654, June 2026.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Targeted dephosphorylation of SMAD3 as an approach to impede TGF-β signaling
iScienceSummary: TGF-β (transforming growth factor-β) signaling is involved in a myriad of cellular processes and its dysregulation has been implicated in many human diseases, including fibrosis and cancer.
Abigail Brewer +8 more
doaj +1 more source
Ubiquitylation and SUMOylation of Cardiac Ion Channels
, 2010 Cardiac ion channels play an essential role in the generation of the action potential of cardiomyocytes. Over the past 15 years, a new field of research called channelopathies has emerged; it regroups all diseases caused by ion channel dysfunction ...
Albesa, Maxime +2 more
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Advanced Science, Volume 13, Issue 31, 4 June 2026.RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li +5 more
wiley +1 more source
PINK1 regulated mitophagy is evident in skeletal muscles
Autophagy ReportsPINK1, mutated in familial forms of Parkinson’s disease, initiates mitophagy following mitochondrial depolarization. However, it is difficult to monitor this pathway physiologically in mice as loss of PINK1 does not alter basal mitophagy levels in most ...
Francois Singh +6 more
doaj +1 more source