Results 101 to 110 of about 939 (187)

Novel process for the preparation of intermediate compounds used in the treatment of migraine [PDF]

The present disclosure relates to a process for the preparation of (S)-2\u27-oxo-1\u27,2\u27,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3\u27-pyrrolo[2,3-b] pyridine]-3-carboxylic acid of formula-1 which is a key intermediate of Ubrogepant and Atogepant.
, MSN Laboratories Private Limited, R&D Center, Hyderabad and India; Srinivasan Thirumalai Rajan, Sajja Eswaraiah, Sagyam Rajeshwar Reddy, Gangajji Parameshwarappa, Velishala Praveen, Eppa Narayana.
core  

Receptors for the Acute Therapy of Migraine: A Literature Review

, 2019
Objective: To review and highlight current literature on emerging acute migraine treatments, focusing on CGRP receptor antagonists, gepants, and 5-HT1F receptor agonists (ditans).
Villar-Martínez, María Dolores, Goadsby, Peter J.; id_orcid, Peter J. Goadsby, Calvin Chan, María Dolores Villar‐Martínez, Moreno-Ajona, David; id_orcid, David Moreno‐Ajona, Chan, Calvin   +7 more
core   +1 more source

ePoster

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

Disproportionality analysis of Raynaud’s phenomenon associated with calcitonin gene-related peptide inhibitors using the Food and Drug Administration adverse event reporting system

Scientific Reports
Raynaud’s phenomenon is a vascular condition characterized by episodic vasoconstriction, and recent reports suggest a potential link between calcitonin gene-related peptide (CGRP) inhibitors, used for migraine treatment, and the onset of this condition ...
Nai Lee, Ji Hoon Ok, Su-jin Rhee, Yun Kim   +3 more
doaj   +1 more source

Contemporary diagnosis and management of vestibular migraine: a systematic review of conventional and CGRP-targeted therapies

Frontiers in Neurology
BackgroundVestibular migraine (VM) is a common cause of recurrent episodic vertigo, and it is associated with significant disability from recurrent vestibular and migraine symptoms.
Saleh Alabood, Laila Aldokhail, Enar Alotaibi, Mayar Alsaqr, Anwar Alshehri, Essa Bakry   +5 more
doaj   +1 more source

Mechanistic role of pyroptosis in Kawasaki disease: An integrative bioinformatics analysis of immune dysregulation, machine learning-based biomarker discovery, WGCNA, and drug repurposing insights.

PLoS ONE
Kawasaki disease (KD) is an acute vasculitis that primarily affects children under five and is a leading cause of acquired heart disease in this age group.
Chen Wang, Qinchao Wu, Jie Chen, Jun Wang, Dan Li   +4 more
doaj   +1 more source

Phase-Transfer-Catalyzed Asymmetric Annulations of Alkyl Dihalides with Oxindoles: Unified Access to Chiral Spirocarbocyclic Oxindoles

A general phase-transfer-catalyzed asymmetric (n+1) (n = 4 or 5) annulation reaction, featuring the direct coupling of simple oxindoles with alkyl dihalides that are allylic/benzylic and non-allylic/benzylic, has been developed to provide previously ...
Yongyi Li (11242842), Xuemin Li (679211), Min Gao (87060), Lin Hu (562273)   +3 more
core   +1 more source

Safety and Tolerability of Combining CGRP Monoclonal Antibodies with Gepants in Patients with Migraine: A Retrospective Study

Neurology and Therapy
Introduction The introduction of clacitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) has revolutionized the treatment of migraines. In clinical practice gepants might be considered as a valid option to treat acute attacks in patients with
Taoufik Alsaadi, Reem Suliman, Vanessa Santos, Ibrahim Al Qaisi, Princess Carmina, Batool Aldaher, Shadi Haddad, Yazan Bader   +7 more
doaj   +1 more source

Effectiveness and Tolerability of Anti-Calcitonin Gene-Related Peptide Therapy for Migraine and Other Chronic Headaches in Adolescents and Young Adults: A Retrospective Study in the USA

Brain Sciences
This retrospective study assesses the efficacy and tolerability of anti-calcitonin gene-related peptide (anti-CGRP) therapy in adolescents and young adults (ages 12–21) with migraine and chronic daily headaches unresponsive to standard treatments ...
Anjaneya Shankar Madhav Bandatmakur, Pooja Dave, Melissa Kerr, Colin Brunick, Sijin Wen, Nicholas Hansen   +5 more
doaj   +1 more source

Effects of anti-calcitonin gene-related peptide medications on blood pressure in people with migraine: Review of FDA submission packages

Cephalalgia Reports
Background Several monoclonal antibodies (mAbs) and small molecule antagonists (gepants) targeting calcitonin gene-related peptide (CGRP) effectively prevent migraine.
Pratheeshan Sabeshan, Anthony Rodgers, Faraidoon Haghdoost   +2 more
doaj   +1 more source