Results 31 to 40 of about 119,003 (273)

Investigation Into the Dynamics of the Cupula in the Vestibular Organ of Adult Zebrafish Using Metabolic Glycoengineering

Angewandte Chemie, EarlyView.
The cupula is a membrane within the vestibular organ that senses rotatory accelerations of the head. Metabolic glycoengineering in combination with bioorthogonal labeling demonstrates that in adult zebrafish – being a model for the human inner ear – this membrane is constantly renewed.
Hans Scherer, Andrea Jüngst, Verena F. Schöwe, Anne‐Katrin Gronewald, Valentin Wittmann   +4 more
wiley   +2 more sources

Identification of UDP-glycosyltransferases involved in the biosynthesis of astringent taste compounds in tea (Camellia sinensis)

Journal of Experimental Botany, 2016
Highlight The identification of three UDP-glycosyltransferases involved in the biosynthesis of galloylated catechins and glycosylated flavonols which are astringent taste compounds in tea.
L. Cui, Shengbo Yao, Xinlong Dai, Qinggang Yin, Yajun Liu, Xiaolan Jiang, Yahui Wu, Yumei Qian, Y. Pang, Liping Gao, Tao Xia   +10 more
semanticscholar   +1 more source

Emotion recognition and cognitive empathy deficits in adolescent offenders revealed by context-sensitive tasks

Frontiers in Human Neuroscience, 2014
Emotion recognition and empathy abilities require the integration of contextual information in real-life scenarios. Previous reports have explored these domains in adolescent offenders (AOs) but have not used tasks that replicate everyday situations.
Maria Luz eGonzalez-Gadea, Maria Luz eGonzalez-Gadea, Maria Luz eGonzalez-Gadea, Eduar eHerrera Murcia, Eduar eHerrera Murcia, Eduar eHerrera Murcia, Mario eParra, Mario eParra, Mario eParra, Mario eParra, Pedro eGomez Mendez, Sandra eBaez, Sandra eBaez, Sandra eBaez, Facundo eManes, Facundo eManes, Facundo eManes, Facundo eManes, Agustin eIbanez, Agustin eIbanez, Agustin eIbanez, Agustin eIbanez   +21 more
doaj   +1 more source

UDP-xylose and UDP-galactose synthesis in Trichomonas vaginalis

Molecular and Biochemical Parasitology, 2012
The presence of xylose and galactose residues in the structure of trichomonad lipoglycans was indicated by previous studies and the modification of any glycoconjugate with either monosaccharide requires the respective presence of the nucleotide sugars, UDP-xylose and UDP-galactose.
Rosenberger, Andrea F.N., Hangelmann, Lydia, Hofinger, Andreas, Wilson, Iain B.H.   +3 more
openaire   +2 more sources

LA INTERPRETACIÓN “ECO-CULTURAL” DE LOS DERECHOS TERRITORIALES DE LOS PUEBLOS INDÍGENAS Y SUS RIESGOS

Revista Chilena de Derecho
Tanto en el Derecho Internacional como en diferentes ordenamientos jurídi-cos domésticos, los derechos territoriales de los pueblos indígenas han sido interpretados siguiendo una comprensión “eco-cultural”.
Cristóbal Carmona Caldera
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

UDP-4-Keto-6-Deoxyglucose, a Transient Antifungal Metabolite, Weakens the Fungal Cell Wall Partly by Inhibition of UDP-Galactopyranose Mutase

mBio, 2017
Can accumulation of a normally transient metabolite affect fungal biology? UDP-4-keto-6-deoxyglucose (UDP-KDG) represents an intermediate stage in conversion of UDP-glucose to UDP-rhamnose. Normally, UDP-KDG is not detected in living cells, because it is
Liang Ma, Omar Salas, Kyle Bowler, Maor Bar-Peled, Amir Sharon   +4 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

SPES3 Facility RELAP5 Sensitivity Analyses on the Containment System for Design Review

Science and Technology of Nuclear Installations, 2012
An Italian MSE R&D programme on Nuclear Fission is funding, through ENEA, the design and testing of SPES3 facility at SIET, for IRIS reactor simulation.
Andrea Achilli, Cinzia Congiu, Roberta Ferri, Fosco Bianchi, Paride Meloni, Davor Grgic, Milorad Dzodzo   +6 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source