Results 51 to 60 of about 119,003 (273)

UDP-glucuronate metabolism controls RIPK1-driven liver damage in nonalcoholic steatohepatitis

Nature Communications, 2023
Hepatocyte apoptosis plays an essential role in the progression of nonalcoholic steatohepatitis (NASH). However, the molecular mechanisms underlying hepatocyte apoptosis remain unclear. Here, we identify UDP-glucose 6-dehydrogenase (UGDH) as a suppressor
Tao Zhang, Na Zhang, Jing Xing, Shuhua Zhang, Yulu Chen, Daichao Xu, Jinyang Gu   +6 more
doaj   +1 more source

Introduction. Law and political economy in Latin America: Problems and perspectives for a transnational agenda

Oñati Socio-Legal Series
This special issue examines the relationship between law and political economy in Latin America, foregrounding historically situated and context-sensitive approaches to the study of legal-economic orders.
Ricardo Valenzuela, Matías Guiloff
doaj   +1 more source

Cascade synthesis of uridine-5′-diphosphate glucuronic acid by coupling multiple whole cells expressing hyperthermophilic enzymes

Microbial Cell Factories, 2019
Background Enzymatic glycan synthesis has leapt forward in recent years and a number of glucuronosyltransferase (EC 2.4.1.17) have been identified and prepared, which provides a guide to an efficient approach to prepare glycans containing glucuronic acid
Dan-Hua Meng, Ran-Ran Du, Lu-Zhou Chen, Meng-Ting Li, Fei Liu, Jin Hou, Yi-Kang Shi, Feng-Shan Wang, Ju-Zheng Sheng   +8 more
doaj   +1 more source

The Biosynthesis of UDP-D-QuiNAc in Bacillus cereus ATCC 14579. [PDF]

PLoS ONE, 2015
N-acetylquinovosamine (2-acetamido-2,6-di-deoxy-D-glucose, QuiNAc) is a relatively rare amino sugar residue found in glycans of few pathogenic gram-negative bacteria where it can play a role in infection.
Soyoun Hwang, Avi Aronov, Maor Bar-Peled
doaj   +1 more source

Identification of a carbohydrate recognition motif of purinergic receptors

eLife, 2023
As a major class of biomolecules, carbohydrates play indispensable roles in various biological processes. However, it remains largely unknown how carbohydrates directly modulate important drug targets, such as G-protein coupled receptors (GPCRs).
Lifen Zhao, Fangyu Wei, Xinheng He, Antao Dai, Dehua Yang, Hualiang Jiang, Liuqing Wen, Xi Cheng   +7 more
doaj   +1 more source

Determination of UDP-Glucose and UDP-Galactose in Maize by Hydrophilic Interaction Liquid Chromatography and Tandem Mass Spectrometry

Journal of Analytical Methods in Chemistry, 2022
Nucleotide sugars, the activated forms of monosaccharides, are important intermediates of carbohydrate metabolism in all organisms. Here, we describe a method for the detection and quantification of UDP-glucose and UDP-galactose in maize in order to ...
Chen Lan, Bing Zhao, Lu Yang, Yusen Zhou, Siyi Guo, Xuebin Zhang, Junli Zhang   +6 more
doaj   +1 more source

Cryptococcus neoformans UGT1encodes a UDP-Galactose/UDP-GalNAc transporter [PDF]

Glycobiology, 2016
Cryptococcus neoformans, an opportunistic fungal pathogen, produces a glycan capsule to evade the immune system during infection. This definitive virulence factor is composed mainly of complex polysaccharides, which are made in the secretory pathway by reactions that utilize activated nucleotide sugar precursors.
Li, L.X., Ashikov, A.M., Liu, H., Griffith, C.L., Bakker, H., Doering, T.L.   +5 more
openaire   +3 more sources

The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley   +1 more source

cDNA Isolation and Functional Characterization of UDP-d-glucuronic Acid 4-Epimerase Family from Ornithogalum caudatum

Molecules, 2016
d-Galacturonic acid (GalA) is an important component of GalA-containing polysaccharides in Ornithogalum caudatum. The incorporation of GalA into these polysaccharides from UDP-d-galacturonic acid (UDP-GalA) was reasonably known.
Sen Yin, Yu-Jia Sun, Ming Liu, Li-Na Li, Jian-Qiang Kong   +4 more
doaj   +1 more source

Characterizing non-hydrolyzing Neisseria meningitidis serogroup A UDP-N-acetylglucosamine (UDP-GlcNAc) 2-epimerase using UDP-N-acetylmannosamine (UDP-ManNAc) and derivatives [PDF]

Carbohydrate Research, 2016
Neisseria meningitidis serogroup A non-hydrolyzing uridine 5'-diphosphate-N-acetylglucosamine (UDP-GlcNAc) 2-epimerase (NmSacA) catalyzes the interconversion between UDP-GlcNAc and uridine 5'-diphosphate-N-acetylmannosamine (UDP-ManNAc). It is a key enzyme involved in the biosynthesis of the capsular polysaccharide [-6ManNAcα1-phosphate-]n of N ...
Zhang, Lei, Muthana, Musleh M, Yu, Hai, McArthur, John B, Qu, Jingyao, Chen, Xi   +5 more
openaire   +4 more sources