Results 61 to 70 of about 97,644 (305)

Chemoenzymatic Synthesis of Heparan Sulfate Oligosaccharides by a Covalent Catch‐and‐Release Approach

Angewandte Chemie, EarlyView.
A glycan having a hydrazide tag enables chemoenzymatic synthesis of HS oligosaccharides. The hydrazide can, under mild acidic conditions, react with an aldehyde‐containing resin to give an immobilized hydrazone that is stable under neutral conditions, allowing washing. The product can be released by transiminolysis using aqueous hydroxylamine to give a
Francesco Palmieri, Chin Huang, Digantkumar Chapla, Kelley W. Moremen, Geert‐Jan Boons   +4 more
wiley   +2 more sources

Depletion of UDP-Glucose and UDP-Galactose Using a Degron System Leads to Growth Cessation of Leishmania major.

PLoS Neglected Tropical Diseases, 2015
Interconversion of UDP-glucose (UDP-Glc) and UDP-galactose (UDP-Gal) by the UDP-Glc 4´-epimerase intimately connects the biosynthesis of these two nucleotide sugars. Their de novo biosynthesis involves transformation of glucose-6-phosphate into glucose-1-
Sebastian Damerow, Carolin Hoppe, Giulia Bandini, Patricia Zarnovican, Falk F R Buettner, Carsten G K Lüder, Michael A J Ferguson, Françoise H Routier   +7 more
doaj   +1 more source

Towards an experimental account of argumentation: the case of the slippery slope and the ad hominem arguments

Frontiers in Psychology, 2014
Argumentation is a crucial component of our lives. Although in the absence of rational debate our legal, political, and scientific systems would not be possible, there is still no integrated area of research on the psychology of argumentation ...
Marco eLillo-Unglaube, Andres eCanales-Johnson, Gorka eNavarrete, Claudio eFuentes   +3 more
doaj   +1 more source

Real‐Time Holographic Feedback via Mixed Reality Sensorized Laryngoscope Training System Enhances Pediatric Intubation Training

Advanced Robotics Research, EarlyView.
We proposed a Mixed Reality Sensorized Laryngoscope Training System to provide real‐time holographic torque feedback during pediatric endotracheal intubation simulation. Visualization formats are evaluated to reduce tracking error and visual demand.
Jiaqi Li, Ryman Hashem, Ningzhe Hou, Perla Maiolino, Louis Halamek, Liang He   +5 more
wiley   +1 more source

Reseña de Property, Power and Politics: Why We Need to Rethink the World Power System. Jean-Philippe Robé. Bristol University Press, 2020

Sortuz
Property, Power and Politics: Why We Need to Rethink the World Power System es una de las contribuciones más ambiciosas del jurista francés Jean-Philippe Robé al debate contemporáneo sobre la relación entre derecho, economía y poder. El libro reconstruye
Ricardo Valenzuela
doaj   +1 more source

UDP-Glucose: A Potential Signaling Molecule in Plants?

Frontiers in Plant Science, 2018
This perspective paper focuses on the most recent results suggesting a potential role for UDP-Glucose as a signaling molecule in plants. In animals, UDP-Glucose is well-established as an extracellular signaling molecule that is sensed by G-protein ...
Henry Christopher Janse van Rensburg, Wim Van den Ende   +1 more
doaj   +1 more source

Uridine Diphosphate Promotes Rheumatoid Arthritis Through P2Y6 Activation

Frontiers in Pharmacology, 2021
BACKGROUND: Uridine diphosphate (UDP) is an extracellular nucleotide signaling molecule implicated in diverse biological processes via specific activation of pyrimidinergic receptor P2Y, G Protein-Coupled, 6 (P2Y6).
Hongxing Wang, Hongxing Wang, Hui Wu, Kehua Fang, Kehua Fang, Xiaotian Chang, Xiaotian Chang   +6 more
doaj   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

O que são os Protocolos e Numero de Portas TCP e UDP na Prática [PDF]

, 2013
Explica sobre os conceitos de porta TCP e UDP, auxiliando na compreensão dos termos e aspectos de cada uma em uma redeEducação Profissional::Informação e ...
Ramos, Leandro
core   +2 more sources

Molecular Mobility of N‐Acetylgalactosamine‐Modified Cyclodextrins on a Polyrotaxane for Highly Efficient Liver Targeting of Antibody Chimeras and Genome‐Editing Ribonucleoproteins

Advanced Science, EarlyView.
Monovalent N‐acetylgalactosamine (GalNAc)‐modified polyrotaxane enables efficient liver targeting by utilizing ligand mobility. The sliding and rotating cyclic components i.e., cyclodextrin in the polyrotaxane dynamically cluster GalNAc moieties, thereby mimicking trivalent interactions with asialoglycoprotein receptors.
Toru Taharabaru, Keiichi Motoyama, Yuting Wen, Zhongxing Zhang, Xuehao Tian, Jun Li, Taishi Higashi   +6 more
wiley   +1 more source