Results 81 to 90 of about 97,644 (305)

Ethanol triggers grape gene expression leading to anthocyanin accumulation during berry ripening [PDF]

, 2002
Recent studies have shown that low doses of ethanol stimulate the maturation of some fruits. The present work showed that spraying Cabernet Sauvignon grapes, with 5% ethanol at veraison enhances the anthocyanin accumulation.
Chervin, Christian, Ashraf El Kereamy, Nepveu, Françoise, Moutounet, Michel, Nepveu, F., Christian Chervin, Chervin, C., Jean-Marc Souquet, Michel Moutounet, Monje, Marie-Carmen, Ford, Christopher, Roustan, Jean-Paul, Christopher M Ford, Helene Mondies, Mondies, H., Souquet, J., Mondies, Hélène, Roustan, J., Jean-Paul Roustan, Ford, C., Ford, Christopher M, van Heeswijck, Robyn, El-Kereamy, Ashraf, Van Heeswijck, R., Françoise Nepveu, Robyn van Heeswijck, Marie-Carmen Monje, Monje, M., El-Kereamy, A., Souquet, Jean-Marc, Moutounet, M.   +30 more
core   +1 more source

Determination of UDP-Glucose and UDP-Galactose in Maize by Hydrophilic Interaction Liquid Chromatography and Tandem Mass Spectrometry

Journal of Analytical Methods in Chemistry, 2022
Nucleotide sugars, the activated forms of monosaccharides, are important intermediates of carbohydrate metabolism in all organisms. Here, we describe a method for the detection and quantification of UDP-glucose and UDP-galactose in maize in order to ...
Chen Lan, Bing Zhao, Lu Yang, Yusen Zhou, Siyi Guo, Xuebin Zhang, Junli Zhang   +6 more
doaj   +1 more source

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, EarlyView.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors : toward the development of novel therapies for African sleeping sickness [PDF]

, 2010
Trypanosoma brucei, the causative agent of human African trypanosomiasis, affects tens of thousands of sub-Saharan Africans. As current therapeutics are inadequate due to toxic side effects, drug resistance, and limited effectiveness, novel therapies are
Michael A. J. Ferguson, Durrant, Jacob D., Ferguson, Michael A. J., Jacob D. Durrant, Ferguson, Michael A. J.; id_orcid, Michael D. Urbaniak, McCammon, J. Andrew, Urbaniak, Michael D., J. Andrew McCammon   +8 more
core   +1 more source

Molecular cloning of a novel glucuronokinase/putative pyrophosphorylase from zebrafish acting in an UDP-glucuronic acid salvage pathway.

PLoS ONE, 2014
In animals, the main precursor for glycosaminoglycan and furthermore proteoglycan biosynthesis, like hyaluronic acid, is UDP-glucuronic acid, which is synthesized via the nucleotide sugar oxidation pathway.
Roman Gangl, Robert Behmüller, Raimund Tenhaken   +2 more
doaj   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

Enzymatic production of hyaluronan oligo- and polysaccharides [PDF]

, 2010
Hyaluronan oligo- and polysaccharides are abundant in the human body. Depending on the chain length, hyaluronan is an important structural component or is involved in influencing cell responses during embryonic development, healing processes ...
Kooy, F.K.
core  

Mining Unclassified Traffic Using Automatic Clustering Techniques [PDF]

, 2011
In this paper we present a fully unsupervised algorithm to identify classes of traffic inside an aggregate. The algorithm leverages on the K-means clustering algorithm, augmented with a mechanism to automatically determine the number of traffic clusters.
Michela Meo, Alessandro Finamore, Mellia, Marco, Meo, Michela, Marco Mellia, Finamore, Alessandro   +5 more
core   +1 more source

Targeting Streptococcus pneumoniae UDP-glucose pyrophosphorylase (UGPase): in vitro validation of a putative inhibitor

Drug Target Insights, 2020
Background: Genome plasticity of Streptococcus pneumoniae is responsible for the reduced efficacy of various antibiotics and capsular polysaccharide based vaccines.
Monica Sharma, Swati Sharma, Pallab Ray, Anuradha Chakraborti   +3 more
doaj   +1 more source

O‐GlcNAcylation Regulation of SNAP29‐Dependent Autophagy Activation Dictates Chemoresistance in Gastric Cancer

Advanced Science, EarlyView.
Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang, Shaoji Zhao, Ziling Shao, Tao Luo, Baifu Peng, Yifan Liu, Jinning Ye, Jianjun Peng, Kaiyu Sun, Jianbo Xu   +9 more
wiley   +1 more source