Results 1 to 10 of about 20,317 (156)

Uridine Diphosphate Promotes Rheumatoid Arthritis Through P2Y6 Activation. [PDF]

Front Pharmacol, 2021
BACKGROUND: Uridine diphosphate (UDP) is an extracellular nucleotide signaling molecule implicated in diverse biological processes via specific activation of pyrimidinergic receptor P2Y, G Protein-Coupled, 6 (P2Y6).
Wang H, Wu H, Fang K, Chang X.
europepmc   +2 more sources

The Uridine diphosphate (UDP)-glycosyltransferases (UGTs) superfamily: the role in tumor cell metabolism. [PDF]

Front Oncol, 2022
UDP-glycosyltransferases (UGTs), important enzymes in biotransformation, control the levels and distribution of numerous endogenous signaling molecules and the metabolism of a wide range of endogenous and exogenous chemicals.
Liu W, Li J, Zhao R, Lu Y, Huang P.
europepmc   +2 more sources

Glucosylation of (±)-Menthol by Uridine-Diphosphate-Sugar Dependent Glucosyltransferases from Plants. [PDF]

Molecules, 2021
Menthol is a cyclic monoterpene alcohol of the essential oils of plants of the genus Mentha, which is in demand by various industries due to its diverse sensorial and physiological properties. However, its poor water solubility and its toxic effect limit
Kurze E, Ruß V, Syam N, Effenberger I, Jonczyk R, Liao J, Song C, Hoffmann T, Schwab W.   +8 more
europepmc   +2 more sources

Genomic-Wide Identification and Characterization of the Uridine Diphosphate Glycosyltransferase Family in Eucommia ulmoides Oliver. [PDF]

Plants (Basel), 2021
Eucommia ulmoides Oliver is a woody plant with great economic and medicinal value. Its dried bark has a long history of use as a traditional medicinal material in East Asia, which led to many glycosides, such as aucubin, geniposide, hyperoside ...
Ouyang D, Wang LC, Tang T, Feng H.
europepmc   +2 more sources

Uridine Diphosphate Glucose (UDP-G) Activates Oxidative Stress and Respiratory Burst in Isolated Neutrophils. [PDF]

Pharmaceuticals (Basel), 2023
The extracellular purinergic agonist uridine diphosphate glucose (UDP-G) activates chemotaxis of human neutrophils (PMN) and the recruitment of PMN at the lung level, via P2Y14 purinergic receptor signaling.
Lairion F, Carbia C, Chiesa IM, Saporito-Magriña C, Borda N, Lazarowski A, Repetto MG.   +6 more
europepmc   +2 more sources

Uridine diphosphate glucose confers oxidative stress tolerance in microalgae. [PDF]

BMC Plant Biol
Background Microalgae, as major primary producers on Earth, are constantly exposed to oxidative stresses from various natural environments. These oxidative stresses often seriously threaten the productivity and species composition of microalgae. However,
Zhang R, Xiao T, Zhu B, Kan C, Chen X, Cao Z, Zhao Y, Li Y, Yang G, Pan K.   +9 more
europepmc   +2 more sources

Uridine diphosphate drives myeloid differentiation and functional reprogramming through dynamic transcriptional network. [PDF]

Front Immunol
BackgroundExtracellular nucleotides regulate immune responses through purinergic signaling. Uridine diphosphate (UDP), a pyrimidine-derived metabolite, has been shown to accumulate in the tumor microenvironment and modulate T cell activation.
Giordano C, Gentile D, Straface E, Gallo R, Cristiani CM, Abatino A, Pastore A, Celano M, Arcucci A, Albano F, Falco G, Veneziano C, Santamaria G, Aversa I, Isdraele Romano L, Palmieri C, Fiume G.   +16 more
europepmc   +2 more sources

Could Postnatal Age-Related Uridine Diphosphate Glucuronic Acid Be a Rate-Limiting Factor in the Metabolism of Morphine During the First Week of Life? [PDF]

CPT Pharmacometrics Syst Pharmacol, 2019
Neonates experience dramatic changes in the disposition of drugs after birth as a result of enzyme maturation and environmental adjustment, challenging therapeutic decision making. In this research, we establish postnatal age, postmenstrual age, and body
Liu T, Lewis TR, Moore JN, Kraft WK, Gauda EB, Sartori D, Moody DE, Gobburu JVS, Ivaturi V.   +8 more
europepmc   +2 more sources

Mechanistic studies of uridine diphosphate glucuronosyltransferase

Chemico-Biological Interactions, 1994
Bisubstrate reaction kinetics and product inhibition studies were used to characterize the kinetic mechanism of a partially purified uridine diphosphate glucuronosyltransferase (UDPGT). These studies indicate that the reaction most likely occurs via a random order sequential mechanism.
Jeffrey P Jones
exaly   +3 more sources

The Effect of Uridine Diphosphate-Glucuronosyltransferase Inhibition on the Pharmacokinetics of Ecopipam and Its Metabolites. [PDF]

Clin Transl Sci
Ecopipam, a selective dopamine D1 receptor antagonist in development for Tourette syndrome, is primarily converted by uridine diphosphate‐glucuronosyltransferase (UGT)1A9 to ecopipam glucuronide, with a minor metabolic pathway by cytochrome P450 3A4 ...
Schmith VD, Graden D, Schleyer J, Wanaski SP.   +3 more
europepmc   +2 more sources