Results 61 to 70 of about 119,003 (273)

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, EarlyView.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

Targeting Streptococcus pneumoniae UDP-glucose pyrophosphorylase (UGPase): in vitro validation of a putative inhibitor

Drug Target Insights, 2020
Background: Genome plasticity of Streptococcus pneumoniae is responsible for the reduced efficacy of various antibiotics and capsular polysaccharide based vaccines.
Monica Sharma, Swati Sharma, Pallab Ray, Anuradha Chakraborti   +3 more
doaj   +1 more source

Hidden O‐Deglycosylation Activity Triggers O → C Rearrangement for Aryl Di‐C‐Glucoside Formation by the C‐Glycosyltransferase From Fortunella crassifolia

Biotechnology and Bioengineering, EarlyView.
Here, we uncovered an unexpected O‐deglycosylation activity of the C glycosyltransferase (FcCGT), forming phloretin (1) from phloretin 2'‐O‐glucoside (2). In the presence of UDP, FcCGT catalyzes the O→C rearrangement to yield nothofagin (3). Upon additional UDP‐glucose, further C‐glycosylation occurs, forming phloretin 3',5'‐di‐C‐glucoside (4 ...
Tuo Li, Annika J. E. Borg, Leo Krammer, Rolf Breinbauer, Bernd Nidetzky   +4 more
wiley   +1 more source

Molecular cloning of a novel glucuronokinase/putative pyrophosphorylase from zebrafish acting in an UDP-glucuronic acid salvage pathway.

PLoS ONE, 2014
In animals, the main precursor for glycosaminoglycan and furthermore proteoglycan biosynthesis, like hyaluronic acid, is UDP-glucuronic acid, which is synthesized via the nucleotide sugar oxidation pathway.
Roman Gangl, Robert Behmüller, Raimund Tenhaken   +2 more
doaj   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

A plant mutase that interconverts UDP-arabinofuranose and UDP-arabinopyranose [PDF]

Glycobiology, 2006
Plant cell walls constitute the bulk of the earth renewable source of energy and are a component in the diet of humans and herbivores. l-Arabinofuranosyl (Araf) residues are a quantifiably important constituent of these walls. Plants use uridine diphosphate (UDP)-l-arabinofuranose (UDP-Araf) to donate Araf residues in the biosynthesis of Araf ...
Teruko, Konishi, Takumi, Takeda, Yasumasa, Miyazaki, Mayumi, Ohnishi-Kameyama, Takahisa, Hayashi, Malcolm A, O'Neill, Tadashi, Ishii   +6 more
openaire   +2 more sources

Unveiling Hepatic Protein Alterations in Neonatal and Infant Biliary Atresia

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric populations differ from adults in drug elimination capacity. While current scaling methods account for enzyme and transporter maturation, they overlook comorbidities, such as biliary atresia (BA), a liver disease appearing within the first 2–8 weeks of life that can progress to cirrhosis.
Zubida M. Al‐Majdoub, Martyn Howard, Brahim Achour, Jill Barber, Naved Alizai, Amin Rostami‐Hodjegan   +5 more
wiley   +1 more source

El enfoque del paradigma funcionalista en torno a la naturaleza, alcances, metas y proyecciones del proceso de reforma educacional

Revista Iberoamericana de Educación, 2008
El presente artículo provee un análisis del enfoque funcionalista en relación a tres aspectos cruciales que inciden tanto en el desarrollo de los sistemas educativos como en los procesos observables al interior de estos: a) la interrelación Estado ...
Óscar Espinoza Díaz
doaj  

First record of the highfin goby Gobionellus oceanicus (Gobiiformes: Gobiidae) in Costa Rican freshwaters

Cuadernos de investigación UNED, 2018
The highfin goby Gobionelus oceanicus is herein reported for the first time in freshwaters of Costa Rica. One specimen was collected in the lower Pacuare River basin, Atlantic slope, Costa Rica.
Francisco S. Álvarez, Derick Herrerea, Arturo Angulo   +2 more
doaj   +1 more source

Bioactivation and Metabolism of Amino Acid MDMA Prodrugs in Zebrafish Embryos, Human Liver S9, Whole Blood, and Microdosed Human Urine

Drug Testing and Analysis, EarlyView.
Bioactivation and metabolism of MDMA prodrugs: MDMA‐Trp, MDMA‐Lys, MDMA‐Gly showed unique urine screening targets only for MDMA‐Trp, while biomarkers for MDMA‐Lys and MDMA‐Gly consisted of MDMA and known MDMA metabolites. Conversion of amino acid prodrugs to MDMA in pHLS9, zebrafish embryos, and humans. ABSTRACT 3,4‐Methylenedioxymethamphetamine (MDMA)
Simon K. Wellenberg, Lea Wagmann, Matthias D. Kroesen, Philip Schippers, Matthias Grill, Jennifer Herrmann, Markus R. Meyer   +6 more
wiley   +1 more source