Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction [PDF]
Substituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner–Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination ...
Brazhko, O. A. +11 more
core
Practical access to planar chiral 1,2-(α-Ketotetramethylene)- ferrocene by non-enzymatic kinetic resolution and conclusive confirmation of its absolute configuration [PDF]
The asymmetric transfer hydrogenation (ATH) of racemic 1,2-(α-ketotetramethylene)ferrocene using the [N-(tosyl)-1,2-diphenylethylendiamine]ruthenium(II) complex [TsDPEN-Ru(II)] as catalyst takes place with a high level of kinetic resolution to deliver ...
Akiyama +98 more
core +1 more source
International audienceA new strategy from simple cyclic β-ketoesters or amides involving a selective three-component reaction and a ring closing metathesis or a palladium catalyzed carbocyclization in a sequential fashion to access spiro-heterocycles is ...
Habib-Zahmani, Hadjira +2 more
core +4 more sources
Meglumine catalyzed one-pot green synthesis of novel 4,7-dihydro-1H-pyrazolo3,4-bpyridin-6-amines [PDF]
Meglumine efficiently catalyzes the one-pot, five-component reaction of hydrazine, ethyl acetoacetate, aryl aldehydes, substituted phenylacetonitriles and ammonium acetate in ethanol at room temperature to afford novel 4,7-dihydro-1H-pyrazolo3,4-bpyridin-
Govindaraju, S. +3 more
core +1 more source
Pentazole and Ammonium Pentazolate: Crystalline Hydro-Nitrogens at High Pressure
Two new crystalline compounds, pentazole (N_{5}H) and ammonium pentazolate (NH_{4})(N_{5}), both featuring cyclo-{\rm N_{5}^{-}} are discovered using first principles evolutionary search of the nitrogen-rich portion of the hydro-nitrogen binary phase ...
Oleynik, Ivan I., Steele, Brad A.
core +4 more sources
Recent Advances in Biocatalytic Promiscuity: Hydrolase-Catalyzed Reactions for Nonconventional Transformations [PDF]
Financial support from the Spanish Ministerio de Economía y Competitividad (CTQ2013-44153-P) is grateful acknowledged. M.L.-I.
Gotor Fernández, Vicente +1 more
core +2 more sources
A structurally conserved motif in γ-herpesvirus uracil-DNA glycosylases elicits duplex nucleotide-flipping [PDF]
Efficient γ-herpesvirus lytic phase replication requires a virally encoded UNG-type uracil-DNA glycosylase as a structural element of the viral replisome.
Bagneris, Claire +5 more
core +2 more sources
Enantiopure Ferrocene-Based Planar-Chiral Iridacycles:Stereospecific Control of Iridium-Centred Chirality [PDF]
Reaction of [IrCp*Cl-2](2) with ferrocenylimines (Fc=NAr, Ar=Ph, p-MeOC6H4) results in ferrocene C-H activation and the diastereoselective synthesis of half-sandwich iridacycles of relative configuration S-p*,R-Ir*.
Albrecht +78 more
core +1 more source
Catalyst optimisation for asymmetric synthesis by ligand chirality element addition - a perspective on stereochemical cooperativity [PDF]
The concept of matched and mismatched stereochemical pairings has been utilised extensively in organic synthesis, with the cooperativity resulting from the former enabling many reactions to proceed with high stereoselectivity.
Arthurs, Ross +1 more
core +1 more source
Background Small polyfunctionalized heterocyclic compounds play important roles in the drug discovery process and in the isolation and structural identification of biological macromolecules.
Florence Bonnaterre +2 more
semanticscholar +1 more source

