Results 41 to 50 of about 2,740,315 (129)

A Systematic Review of the Costs of Drug‐Associated Acute Kidney Injury and Potential Cost Savings With Nephrotoxin Stewardship Prevention Strategies

Clinical Pharmacology &Therapeutics, Volume 117, Issue 4, Page 989-1004, April 2025.
There is a scarcity of information related to the financial impact of acute kidney injury (AKI), and even more so the economics of drug‐associated AKI (D‐AKI). Our goal was to provide a comprehensive summary of the economic burden of D‐AKI by evaluating the costs of D‐AKI compared to not developing AKI and cost savings associated with nephrotoxin ...
Britney A. Stottlemyer, Tiffany Tran, Kangho Suh, Sandra L. Kane‐Gill   +3 more
wiley   +1 more source

Organocatalytic Double Ugi Reaction with Statistical Amplification of Product Enantiopurity: A Linker Cleavage Approach To Access Highly Enantiopure Ugi Products

Here we report an organocatalytic double Ugi reaction combining the enantioselective process and ee enhancement in a single operation to afford the chiral Ugi products with very high ee values.
Tong, Shuo, Wang, Mei-Xiang, Zhu, Jieping, Feng, Qi-Yun   +3 more
core   +1 more source

Peptide array functionalization via the Ugi four-component reaction

, 2017
The Ugi four-component reaction was investigated as a tool for the functionalization of peptide arraysviapost-synthetic side-chain modification as well as integration of an Ugi unit into a growing peptide chain.
M. A. R. Meier, Mattes, D. S., Breitling, F., Ridder, B., F. Breitling, D. S. Mattes, Meier, M. A. R., Nesterov-Mueller, A., A. Nesterov-Mueller, B. Ridder   +9 more
core   +1 more source

Rapid Access to Oxindoles by the Combined Use of an Ugi Four-Component Reaction and a Microwave-Assisted Intramolecular Buchwald−Hartwig Amidation Reaction

, 2016
A two-step sequence involving an Ugi four-component reaction (Ugi-4CR) and a palladium-catalyzed intramolecular amidation of aryl iodide has been developed for rapid access to functionalized oxindole (1).
Michèle Bois-Choussy (2489410), Jieping Zhu (1450051), Florence Bonnaterre (2528347)   +2 more
core   +1 more source

Recent Applications of Sulfonium Salts in Synthesis and Catalysis

Chemistry – A European Journal, Volume 30, Issue 70, December 13, 2024.
This review summarizes the recent developments on the synthetic applications of sulfonium salts with an emphasis on the description of the operating mechanistic pathways. Abstract The use of sulfonium salts in organic synthesis has experienced a dramatic increase during the last years that can arguably be attributed to three main factors; the ...
Sven Timmann, Zeyu Feng, Manuel Alcarazo
wiley   +1 more source

Protein-Templated Hit Identification through an Ugi Four-Component Reaction. [PDF]

, 2020
Kinetic target-guided synthesis represents an efficient hit-identification strategy, in which the protein assembles its own inhibitors from a pool of complementary building blocks via an irreversible reaction. Herein, we pioneered an in situ Ugi reaction
Jumde, Varsha R, Blankenfeldt, Wulf, Müller, Rolf, Mancini, Federica, Alaa Alhayek, Unver, M Yagiz, Elgaher, Walid A M, Witte, Martin D, Varsha R. Jumde, Rolf Müller, Hirsch, Anna K.H., Witte, Martin D., Köck, Matthias, Federica Mancini, M. Yagiz Unver, Unver, M. Yagiz, Jennifer Herrmann, Wulf Blankenfeldt, Peer Lukat, Matthias Köck, Hirsch, Anna K H, Martin D. Witte, Anna K. H. Hirsch, Alhayek, Alaa, Witte, Martin D.; id_orcid, Lukat, Peer, Herrmann, Jennifer, Walid A. M. Elgaher, Jumde, Varsha R., Elgaher, Walid A.M.   +29 more
core   +2 more sources

DFT Studies on the Stereoselective Three-Component Ugi Reaction [PDF]

, 2019
Mechanism and stereochemistry of three component Ugi reaction (3C-Ugi) were studied theoretically based on DFT calculations. Structures of reagents, products, intermediates, and transition states were optimized at M062X/6-31+g(d,p) level of theory in gas
Nader Zabarjad Shiraz, Elaheh Sadat Sharifzadeh, Sharifzadeh, Elaheh Sadat, Shiraz, Nader Zabarjad   +3 more
core   +1 more source

Catalytic Three-Component Ugi Reaction

, 2008
Perfect atom economy characterizes a novel catalytic three‐component Ugi reaction (see example). Different α‐amino amides are formed in good yields from aldehydes, primary amines, and isocyanides in the presence of phenyl phosphinic acid as the catalyst.
List, B., Pan, S.
core   +1 more source

Datasets for BAYOMA with FIM (Zhu et.al MSSP 2022)

, 2022
This folder contains the synthetic and laboratory datasets used in Section 6 of Zhu Z, Au SK, Li BB (2022). “Accelerating Convergence in Bayesian Operational Modal Analysis with Fisher Information Matrix”.
Li, Binbin, Au, Siu-Kui, Zhu, Zuo
core   +1 more source

‐heterocycles Using the Ugi Four‐Center Three‐Component Reaction

, 2019
Ugi four-center three-component reaction (U-4 C-3CR) as actually an important development of the well-known Ugi four-component reaction (U-4CR). In U-4 C-3CR, one of the components is bifunctional, reducing the components of U-4CR to three components ...
M Heravi; Majid, Majid M Heravi, Mohammadkhani, L., Leyla Mohammadkhani   +3 more
core   +1 more source