Results 41 to 50 of about 2,093 (93)

Preparation of 4 '-spirocyclobutyl nucleoside analogues as novel and versatile adenosine scaffolds

, 2019
Despite the large variety of modified nucleosides that have been reported, the preparation of constrained 4 '-spirocyclic adenosine analogues has received very little attention.
De Vleeschouwer, Freija, Kong, Hanchu, Meerpoel, Lieven, Pande, Vineet, Sun, Weimei, Thuring, Jan Willem, Van Hecke, Kristof, Verhoeven, Jonas, Verniest, Guido, Vos, Ann, Wu, Tongfei   +10 more
core   +1 more source

Recent advances in the catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides [PDF]

, 2014
Catalytic asymmetric 1,3-dipolar cycloadditions of azomethine ylides have turned out to be one of the most efficient methods for the preparation of enantioenriched pyrrolidines.
Adrio, Javier, Carretero, Juan C.
core   +2 more sources

Development of cytosine and adenine base editors for maize precision breeding

Journal of Integrative Plant Biology, Volume 67, Issue 10, Page 2731-2743, October 2025.
A series of maize cytosine and adenine base editors was developed using various deaminase variants, enabling efficient multiplex genome editing in maize. Precise editing of the ZmACC1/2 genes generated herbicide‐tolerant maize germplasm, offering a solution for weed management in maize‐soybean intercropping systems.
Xiao Fu, Nan Wang, Lina Li, Dexin Qiao, Xiantao Qi, Changlin Liu, Zhaoxu Gao, Chuanxiao Xie, Jinjie Zhu   +8 more
wiley   +1 more source

The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma. [PDF]

, 2014
Blocking the bioactivity of allergens is conceptually attractive as a small-molecule therapy for allergic diseases but has not been attempted previously.
Anandan C., Arbes S. J., Asokananthan N., Billson J., Boyd M. J., Brown A., Brown A. D., Chan W. C., Chen J. C., Clive Robinson, Comoy E. E., David R. Garrod, Fattouh R., Gary K. Newton, Gelber L. E., Gough L., Jahnsen F. L., Jie Chen, Jihui Zhang, Jonathan P. Richardson, Kerry Jenkins, King C., Liu H., Marcaccini S., Mark R. Stewart, Meriel R. Major, Milan D. S., Moffatt M. F., Möller G. M., Nicola J. Francis-Newton, Peat J. K., Peat J. K., Pei Lai, Pichavant M., Platts-Mills T. A., Platts-Mills T. A., Platts-Mills T. A. E., Platts-Mills T. A. E., Prefontaine D., Purello-D’Ambrosia F., Rebekah E. Key, Robinson C., Silvestri M., Smith J. M., Sporik R., Squillace S. P., Steven M. Lloyd, Stewart G. A., Stuart Firth-Clark, Takai T., Trevor R. Perrior, Wan H., Ying S., Zhang J., Zhang J., Zhang J., Zhang J.   +56 more
core   +2 more sources

Machine Learning‐Enhanced Nanoparticle Design for Precision Cancer Drug Delivery

Advanced Science, Volume 12, Issue 30, August 14, 2025.
Machine Learning (ML) is revolutionizing cancer nanomedicine by optimizing nanoparticle (NP) design and drug delivery. This review summarizes ML applications across all stages of NP drug delivery, along with a discussion of ongoing challenges and future directions.
Qingquan Wang, Yujian Liu, Chenchen Li, Bin Xu, Shidang Xu, Bin Liu   +5 more
wiley   +1 more source

A Systematic Review of the Costs of Drug‐Associated Acute Kidney Injury and Potential Cost Savings With Nephrotoxin Stewardship Prevention Strategies

Clinical Pharmacology &Therapeutics, Volume 117, Issue 4, Page 989-1004, April 2025.
There is a scarcity of information related to the financial impact of acute kidney injury (AKI), and even more so the economics of drug‐associated AKI (D‐AKI). Our goal was to provide a comprehensive summary of the economic burden of D‐AKI by evaluating the costs of D‐AKI compared to not developing AKI and cost savings associated with nephrotoxin ...
Britney A. Stottlemyer, Tiffany Tran, Kangho Suh, Sandra L. Kane‐Gill   +3 more
wiley   +1 more source

Molecular access to multi-dimensionally encoded information [PDF]

, 2019
Polymer scientist have only recently realized that information storage on the molecular level is not only restricted to DNA-based systems. Similar encoding and decoding of data have been demonstrated on synthetic polymers that could overcome some of the ...
Aksakal, Resat, Du Prez, Filip, Steinkönig, Jan   +2 more
core   +1 more source

Recent Applications of Sulfonium Salts in Synthesis and Catalysis

Chemistry – A European Journal, Volume 30, Issue 70, December 13, 2024.
This review summarizes the recent developments on the synthetic applications of sulfonium salts with an emphasis on the description of the operating mechanistic pathways. Abstract The use of sulfonium salts in organic synthesis has experienced a dramatic increase during the last years that can arguably be attributed to three main factors; the ...
Sven Timmann, Zeyu Feng, Manuel Alcarazo
wiley   +1 more source

Practical access to planar chiral 1,2-(α-Ketotetramethylene)- ferrocene by non-enzymatic kinetic resolution and conclusive confirmation of its absolute configuration [PDF]

, 2015
The asymmetric transfer hydrogenation (ATH) of racemic 1,2-(α-ketotetramethylene)ferrocene using the [N-(tosyl)-1,2-diphenylethylendiamine]ruthenium(II) complex [TsDPEN-Ru(II)] as catalyst takes place with a high level of kinetic resolution to deliver ...
Akiyama, Alba, Alba, Arae, Arae, Aratani, Arrayás, Atkinson, Barbaro, Blaser, Bolm, Braga, Butt, Chen, Colacot, Cotarca, Dai, Dai, David, Deng, Enders, Enders, Enders, Fabre, Ferber, Fouda, Fu, Fujii, Fukuda, Ganter, Gao, Gao, Gasser, Hartinger, Hashiguchi, Hayes, Ikariya, Izumi, Jedlická, Jolley, Kitzler, Kuehne, Latorre, Laufer, Liu, Locke, Ma, Marquarding, Matsuoka, Metallinos, Miyagi, Nishibayashi, Noyori, Ogasawara, Patti, Patti, Peters, Pi, Pi, Price, Rebière, Ren, Riant, Richards, Richards, Sammakia, Schaarschmidt, Schlögl, Schlögl, Shibata, Simpson, Sokolov, Stavrakov, Stavrakov, Steffen, Stepnicka, Sturm, Tanaka, Tarafder, Thomson, Togni, Tropiano, Tsukazaki, Ursini, van Staveren, Vinci, Václavík, Wally, Wally, Wang, Wang, Watanabe, Wildhalm, Xiao, Yao, Zhang, Zhang, Zhang, Zhoua   +98 more
core   +1 more source

Isonitrile Photochemistry: A Functional Group Class Coming in from the Cold

Chemistry – A European Journal, Volume 30, Issue 64, November 15, 2024.
Isonitriles, often neglected for their unpleasant smell, have fascinated many generations of chemists thanks to unique reactivity modes. The present concept article, by retracing the seeds of isonitrile photochemistry, points out the hidden opportunities offered by visible light photo(redox) catalysis to promote key advancements in the field.
Mariateresa Giustiniano
wiley   +1 more source