Results 31 to 40 of about 23,282 (131)
, 2019 Here we report an organocatalytic double Ugi reaction combining the enantioselective process and ee enhancement in a single operation to afford the chiral Ugi products with very high ee values.
Mei-Xiang Wang +7 more
core +1 more source
Hydrazine in the Ugi tetrazole reaction [PDF]
, 2016 We describe the hitherto unknown use of N-Boc-protected hydrazine in the Ugi tetrazole reaction to access a library of highly substituted 5-(hydrazinomethyl)-1-methyl-1H-tetrazoles. The reaction is very versatile and good to high yielding. A one-pot, two-
Patil, Pravin +5 more
core +1 more source
Artificial intelligence‐assisted design, synthesis and analysis of smart biomaterials
BMEMat, Volume 3, Issue 4, December 2025.Smart biomaterials are rapidly emerging as tools for tissue engineering, and artificial intelligence has played essential roles in biomaterial studies. By bridging the literature gap in AI‐based design, synthesis and analysis of smart biomaterials, the current review shares perspectives on how biomaterial scientists can practically incorporate AI for ...
Pengfei Jiang +9 more
wiley +1 more source
Multicomponent Synthesis of Fluorine‐Containing Bioactive Compounds and Drugs
European Journal of Organic Chemistry, Volume 28, Issue 38, October 15, 2025.Multicomponent reactions are robust synthetic tools to assamble complex polyheterocycles and other interesting molecular architectures with potential application in medicinal chemistry, including their fluorine‐containing analogues. Fluorine atoms placed strategically into bioactive molecules often enhance essential pharmacokinetic parameters like ...
Ivette Morales‐Salazar +7 more
wiley +1 more source
Ugi Four-Component Reaction of Alcohols: Stoichiometric and Catalytic Oxidation/MCR Sequences
, 2016 A new, simple, and efficient procedure for the one-pot Ugi four-component reaction of alcohols instead of aldehydes is described. Using a stoichiometric amount of IBX or only 1–2% of sodium 2-iodobenzenesulfonate in the presence of Oxone, a wide range of
Jieping Zhu (1450051) +2 more
core +1 more source
An Ugi Reaction Incorporating a Redox-Neutral Amine C–H Functionalization Step
, 2016 Pyrrolidine and 1,2,3,4-tetrahydroisoquinoline (THIQ) undergo redox-neutral α-amidation with concurrent N-alkylation upon reaction with aromatic aldehydes and isocyanides.
Zhengbo Zhu (1429915) +1 more
core +1 more source
Machine Learning‐Enhanced Nanoparticle Design for Precision Cancer Drug Delivery
Advanced Science, Volume 12, Issue 30, August 14, 2025.Machine Learning (ML) is revolutionizing cancer nanomedicine by optimizing nanoparticle (NP) design and drug delivery. This review summarizes ML applications across all stages of NP drug delivery, along with a discussion of ongoing challenges and future directions.
Qingquan Wang +5 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 117, Issue 4, Page 989-1004, April 2025.There is a scarcity of information related to the financial impact of acute kidney injury (AKI), and even more so the economics of drug‐associated AKI (D‐AKI). Our goal was to provide a comprehensive summary of the economic burden of D‐AKI by evaluating the costs of D‐AKI compared to not developing AKI and cost savings associated with nephrotoxin ...
Britney A. Stottlemyer +3 more
wiley +1 more source
Peptide array functionalization via the Ugi four-component reaction
, 2017 The Ugi four-component reaction was investigated as a tool for the functionalization of peptide arraysviapost-synthetic side-chain modification as well as integration of an Ugi unit into a growing peptide chain.
M. A. R. Meier +9 more
core +1 more source
, 2016 A two-step sequence involving an Ugi four-component reaction (Ugi-4CR) and a palladium-catalyzed intramolecular amidation of aryl iodide has been developed for rapid access to functionalized oxindole (1).
Michèle Bois-Choussy (2489410) +2 more
core +1 more source