Results 31 to 40 of about 2,093 (93)

Total Synthesis of Discobahamin A and Putative Structure of Discobahamin B via an Isocyanide‐based Macrocyclization Reaction

Angewandte Chemie, Volume 137, Issue 10, March 3, 2025.
An isocyanide‐based macrocyclization, involving the formation of a C(sp3)‐C(sp2) bond and the concurrent generation of an α‐acyloxy amide functional group, has been developed and successfully applied to the total synthesis of discobahamin A, a 24‐membered macrocyclopeptide. Abstract We report in this paper the first total synthesis of discobahamin A, a
Baochao Yang, Qian Wang, Jieping Zhu
wiley   +2 more sources

Studies on the Synthesis of DMAP Derivatives by Diastereoselective Ugi Reactions [PDF]

, 2011
Diastereoselective Ugi reactions of DMAP-based aldehydes with α-amino acids and tert-butyl isocyanide were examined. The reactions of 4-(dimethylamino)-2-pyridine-carboxaldehyde with various α-amino acids afforded 2-substituted DMAP derivatives with low ...
Irie, Shunsuke, Mandai, Hiroki, Mitsudo, Koichi, Suga, Seiji   +3 more
core   +3 more sources

Recent Contributions of Organic Synthesis to Forensic Science

ChemPlusChem, Volume 91, Issue 2, February 2026.
Forensic science is a multidisciplinary field that plays a vital role in providing scientific evidence for criminal investigations. This review highlights advances and opportunities at the interface between organic synthesis and forensic science, with applications in drug identification, forensic toxicology, and latent fingerprint detection and ...
Gustavo dos Santos Martins, Mariana dos Santos Dupim, Rodrigo Garcia Agostinho, Fernanda Gadini Finelli   +3 more
wiley   +1 more source

Deep Eutectic Solvents: The Organic Reaction Medium of the Century [PDF]

, 2016
This microreview summarizes the use of deep eutectic solvents (DESs) and related melts in organic synthesis. Solvents of this type combine the great advantages of other proposed environmentally benign alternative solvents, such as low toxicity, high ...
Abbott, Abbott, Abbott, Abbott, Abbott, Abbott, Abbott, Abo-Hamad, Amelio, Aparicio, Assanosi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Bafti, Bakavoli, Beckman, Bednarz, Borse, Cao, Cardellini, Carriazo, Chahdoura, Chai, Chaskar, Chen, Chen, Constable, Cragg, Dai, Dai, Dai, Dai, Davey, De Oliveira Vigier, De Oliveira Vigier, De Santi, del Monte, Disale, Domínguez de María, Domínguez de María, Duan, Dupont, Durand, Díaz-Álvarez, Earle, Ferreira, Fischer, Francisco, Gambino, García, García-Verdugo, García-Álvarez, García-Álvarez, Gill, Gore, Gorke, Gu, Guajardo, Gupta, Hallet, Handy, Handy, Handy, Hari, Hawkins, Hayyan, Henderson, Hu, Hu, Ilgen, Ilgen, Imperato, Imperato, Imperato, Itoh, Jella, Jérôme, Karmakar, Kemeling, Keshavarzipour, Khandelwal, Krishnakumar, Kumar, Kus, Laird, Lavilla, Li, Li, Li, Li, Lindström, Liu, Liu, Liu, Lobo, Lobo, Lu, Macaev, Machida, Mahboub, Mallardo, Martins, Matsuda, Maugeri, Maugeri, Maugeri, Mobinikhaledi, Morales, More, Müller, Müller, Pace, Pal, Pandey, Patil, Pavia, Pawar, Pednekar, Pena-Pereira, Pena-Pereira, Peters, Phadtare, Phadtare, Pincock, Pérez, Pérez-Sánchez, Radošević, Rastogi, Reddy, Rodríguez-Álvarez, Ruß, Saberi, Sanap, Sanap, Santos, Sassone, Scholten, Serrano, Sheldon, Shuklov, Singh, Singh, Singh, Singh, Singh, Smith, Sonawane, Steinrück, Stepankova, Sunitha, Tanaka, Tang, Tang, Vidal, Vidal, Vidal, Wagle, Wang, Wang, Wang, Wang, Wang, Wang, Wasserscheid, Welton, Xia, Yadav, Yadav, Yadav, Yu, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zhao   +192 more
core   +2 more sources

One‐Pot Morita–Baylis–Hillman/Allylic Substitution in Deep Eutectic Solvents: Access to γ‐Hydroxy Derivatives via Sequential CC and CX (X = P, N, S, B, Si) Bond Formation

ChemSusChem, Volume 19, Issue 1, January 2026.
Sustainable one‐pot synthesis of functionalized γ‐hydroxy derivatives in deep eutectic solvents. A green, sequential CC/CX bond‐forming strategy enables diverse γ‐hydroxy derivatives via Morita–Baylis–Hillman and nucleophilic functionalization in ChCl/Gly deep eutectic solvent.
Marina Ramos‐Martín, Ignacio del Río, Joaquín García‐Álvarez, Alejandro Presa Soto   +3 more
wiley   +1 more source

Artificial intelligence‐assisted design, synthesis and analysis of smart biomaterials

BMEMat, Volume 3, Issue 4, December 2025.
Smart biomaterials are rapidly emerging as tools for tissue engineering, and artificial intelligence has played essential roles in biomaterial studies. By bridging the literature gap in AI‐based design, synthesis and analysis of smart biomaterials, the current review shares perspectives on how biomaterial scientists can practically incorporate AI for ...
Pengfei Jiang, Yefei Dai, Yujun Hou, Joshua Stein, Shichen Steven Lin, Chaochen Zhou, Yannan Hou, Rongrong Zhu, Ki‐Bum Lee, Letao Yang   +9 more
wiley   +1 more source

Isocyanide based multicomponent reactions of oxazolidines and related systems [PDF]

, 2010
N-Alkyloxazolidines react in a multicomponent reaction with carboxylic acids and isocyanides to give N-acyloxyethylamino acid amides. The previously reported reaction conditions were improved using a design of experiments approach (DoE).
Diorazio, LJ, Motherwell, WB, Sheppard, TD, Taylor, BA, Waller, RW   +4 more
core   +1 more source

Multicomponent Synthesis of Fluorine‐Containing Bioactive Compounds and Drugs

European Journal of Organic Chemistry, Volume 28, Issue 38, October 15, 2025.
Multicomponent reactions are robust synthetic tools to assamble complex polyheterocycles and other interesting molecular architectures with potential application in medicinal chemistry, including their fluorine‐containing analogues. Fluorine atoms placed strategically into bioactive molecules often enhance essential pharmacokinetic parameters like ...
Ivette Morales‐Salazar, Perla Islas‐Jácome, Leonardo D. Herrera‐Zuñiga, Samuel Couve‐Bonnaire, Philippe Jubault, Eduardo González‐Zamora, Jean‐Philippe Bouillon, Alejandro Islas‐Jácome   +7 more
wiley   +1 more source

Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum [PDF]

, 2009
Plasmodium falciparum, the Apicomplexan parasite that is responsible for the most lethal forms of human malaria, is exposed to radically different environments and stress factors during its complex lifecycle.
Annette N. Chiang, Banumathy, Billy W. Day, Botha, Brian P. Mead, Chiu, Corinne Schneider, Craig, David A. Fidock, Donna M. Huryn, Ekland, Fernandez-Saiz, Fewell, Fewell, Fewell, Fidock, Frydman, Hartl, Hunt, Jeffrey L. Brodsky, Jiang, Juan-Carlos Valderramos, Maier, Matambo, Mayer, McClellan, McKerrow, Michael G. Klein, Midorikawa, Nadeau, Noedl, Pavithra, Pecoul, Peter Wipf, Raghavan Balachandran, Raj J. Chovatiya, Ramya, Rodina, Samantha L. Bell, Shonhai, Shonhai, Sidhu, Tang, Tonkin, Wellems, Werner, Wright, Xiaojiang S. Chen, Youker   +48 more
core   +1 more source

Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction [PDF]

, 2019
Substituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner–Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination ...
Brazhko, O. A., Chebanov, V. A., Desenko, S. M., Dyakonenko, V. V., Kolomiets, O. V., Kornet, M. M., Murlykina, M. M., Musatov, V. I., Sakhno, Y. I., Shishkina, S. V., Tsygankov, A. V., Van der Eycken, E. V.   +11 more
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