Results 31 to 40 of about 2,740,315 (129)

Organocatalytic Double Ugi Reaction with Statistical Amplification of Product Enantiopurity: A Linker Cleavage Approach To Access Highly Enantiopure Ugi Products

, 2019
Here we report an organocatalytic double Ugi reaction combining the enantioselective process and ee enhancement in a single operation to afford the chiral Ugi products with very high ee values.
Mei-Xiang Wang, Shuo Tong (2796949), Jieping Zhu, Jieping Zhu (1450051), Qi-Yun Feng, Qi-Yun Feng (8194815), Mei-Xiang Wang (536990), Shuo Tong   +7 more
core   +1 more source

Copper‐ and Silver‐Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five‐ and Six‐Membered Heterocycles

Chemistry – A European Journal, Volume 32, Issue 13, 1 April 2026.
This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
Jimil George, Kyungsoo Oh
wiley   +1 more source

Total Synthesis of Discobahamin A and Putative Structure of Discobahamin B via an Isocyanide‐based Macrocyclization Reaction

Angewandte Chemie, Volume 137, Issue 10, March 3, 2025.
An isocyanide‐based macrocyclization, involving the formation of a C(sp3)‐C(sp2) bond and the concurrent generation of an α‐acyloxy amide functional group, has been developed and successfully applied to the total synthesis of discobahamin A, a 24‐membered macrocyclopeptide. Abstract We report in this paper the first total synthesis of discobahamin A, a
Baochao Yang, Qian Wang, Jieping Zhu
wiley   +2 more sources

Ugi Four-Component Reaction of Alcohols: Stoichiometric and Catalytic Oxidation/MCR Sequences

, 2016
A new, simple, and efficient procedure for the one-pot Ugi four-component reaction of alcohols instead of aldehydes is described. Using a stoichiometric amount of IBX or only 1–2% of sodium 2-iodobenzenesulfonate in the presence of Oxone, a wide range of
Jieping Zhu (1450051), Fleur Drouet (1951267), Géraldine Masson (1525453)   +2 more
core   +1 more source

'Atypical Ugi' tetrazoles [PDF]

, 2020
Amino acid-derived isocyano amides together with TMSN3, oxocomponents and 1° or 2° amines are common substrates in the Ugi tetrazole reaction. We surprisingly found that combining these substrates gives two different constitutional isomeric Ugi products ...
Abdelraheem, Eman M M, Dömling, Alexander, Goodwin, Imogen, Shaabani, Shabnam, Abdelraheem, Eman M. M., de Haan, Michel P., Kalinowska-Tłuścik, Justyna, Kurpiewska, Katarzyna, de Haan, Michel P   +8 more
core   +2 more sources

Artificial intelligence‐assisted design, synthesis and analysis of smart biomaterials

BMEMat, Volume 3, Issue 4, December 2025.
Smart biomaterials are rapidly emerging as tools for tissue engineering, and artificial intelligence has played essential roles in biomaterial studies. By bridging the literature gap in AI‐based design, synthesis and analysis of smart biomaterials, the current review shares perspectives on how biomaterial scientists can practically incorporate AI for ...
Pengfei Jiang, Yefei Dai, Yujun Hou, Joshua Stein, Shichen Steven Lin, Chaochen Zhou, Yannan Hou, Rongrong Zhu, Ki‐Bum Lee, Letao Yang   +9 more
wiley   +1 more source

Multicomponent Synthesis of Fluorine‐Containing Bioactive Compounds and Drugs

European Journal of Organic Chemistry, Volume 28, Issue 38, October 15, 2025.
Multicomponent reactions are robust synthetic tools to assamble complex polyheterocycles and other interesting molecular architectures with potential application in medicinal chemistry, including their fluorine‐containing analogues. Fluorine atoms placed strategically into bioactive molecules often enhance essential pharmacokinetic parameters like ...
Ivette Morales‐Salazar, Perla Islas‐Jácome, Leonardo D. Herrera‐Zuñiga, Samuel Couve‐Bonnaire, Philippe Jubault, Eduardo González‐Zamora, Jean‐Philippe Bouillon, Alejandro Islas‐Jácome   +7 more
wiley   +1 more source

An Ugi Reaction Incorporating a Redox-Neutral Amine C–H Functionalization Step

, 2016
Pyrrolidine and 1,2,3,4-tetrahydroisoquinoline (THIQ) undergo redox-neutral α-amidation with concurrent N-alkylation upon reaction with aromatic aldehydes and isocyanides.
Zhengbo Zhu (1429915), Daniel Seidel (348104)   +1 more
core   +1 more source

SYNTHESIS OF AZULENE AMIDE DERIVATIVES BY SOLVENT-FREE UGI REACTION [PDF]

, 2014
A simple and eco-friendly synthesis of azulene amide derivatives has achieved via solvent-free Ugi reaction. We found that efficient solvent-free reactions required the formation of a liquid phase throughout the course of the reactions.
熊倉 健太
core  

Machine Learning‐Enhanced Nanoparticle Design for Precision Cancer Drug Delivery

Advanced Science, Volume 12, Issue 30, August 14, 2025.
Machine Learning (ML) is revolutionizing cancer nanomedicine by optimizing nanoparticle (NP) design and drug delivery. This review summarizes ML applications across all stages of NP drug delivery, along with a discussion of ongoing challenges and future directions.
Qingquan Wang, Yujian Liu, Chenchen Li, Bin Xu, Shidang Xu, Bin Liu   +5 more
wiley   +1 more source