Results 11 to 20 of about 23,282 (131)

NMR-Based Structural Analysis of Highly Substituted Pyridines From Kondrat'eva Aza-Diels-Alder Cycloadditions. [PDF]

Magn Reson Chem
We report the results from a kinetic and mechanistic investigation of an inverse‐electron‐demand Diels–Alder (IEDDA) cycloaddition involving an oxazole‐type diene synthesized via an Ugi–Zhu multicomponent reaction (UZ‐3CR). ABSTRACT Pyridines are a crucial class of heterocycles with widespread applications in natural products, pharmaceuticals, and ...
Suárez-Moreno GV, Méndez F, Gutierrez-Carrillo A, Rincón-Guevara MA, Amador-Sánchez YA, Islas-Jácome A, González-Zamora E.   +6 more
europepmc   +2 more sources

The Multifaceted Legacy of Thalidomide: Chemistry and Biology Driving Modern Drug Design. [PDF]

ChemMedChem
Thalidomide serves as a molecular nexus linking chemistry and biology: advances in synthesis and structural understanding enable protein degradation technologies, while its immunomodulatory activity underpins anti‐inflammatory and anticancer therapies.
Nikovia K, Kapsalis M, Georgoulakis M, Panousis A, Neochoritis CG.   +4 more
europepmc   +2 more sources

Development of cytosine and adenine base editors for maize precision breeding. [PDF]

J Integr Plant Biol
A series of maize cytosine and adenine base editors was developed using various deaminase variants, enabling efficient multiplex genome editing in maize. Precise editing of the ZmACC1/2 genes generated herbicide‐tolerant maize germplasm, offering a solution for weed management in maize‐soybean intercropping systems.
Fu X, Wang N, Li L, Qiao D, Qi X, Liu C, Gao Z, Xie C, Zhu J.   +8 more
europepmc   +2 more sources

One-Pot Morita-Baylis-Hillman/Allylic Substitution in Deep Eutectic Solvents: Access to γ-Hydroxy Derivatives via Sequential CC and CX (X = P, N, S, B, Si) Bond Formation. [PDF]

ChemSusChem
Sustainable one‐pot synthesis of functionalized γ‐hydroxy derivatives in deep eutectic solvents. A green, sequential CC/CX bond‐forming strategy enables diverse γ‐hydroxy derivatives via Morita–Baylis–Hillman and nucleophilic functionalization in ChCl/Gly deep eutectic solvent.
Ramos-Martín M, Del Río I, García-Álvarez J, Presa Soto A.   +3 more
europepmc   +2 more sources

Recent Contributions of Organic Synthesis to Forensic Science. [PDF]

Chempluschem
Forensic science is a multidisciplinary field that plays a vital role in providing scientific evidence for criminal investigations. This review highlights advances and opportunities at the interface between organic synthesis and forensic science, with applications in drug identification, forensic toxicology, and latent fingerprint detection and ...
Dos Santos Martins G, Dos Santos Dupim M, Garcia Agostinho R, Gadini Finelli F.   +3 more
europepmc   +2 more sources

Protein-Templated Hit Identification via an Ugi Four-Component Reaction

, 2020
Kinetic target-guided synthesis represents an efficient hit-identification strategy, in which the protein assembles its own inhibitors from a pool of building blocks via an irreversible reaction.
jennifer, herrmann, Martin D., Witte, Matthias, Köck, M. Yagiz, Unver, Varsha R., Jumde, Peer, Lukat, rolf, müller, Wulf, Blankenfeldt, Federica, Mancini, Anna K.H., Hirsch, Walid, Elgaher, Alaa, Alhayek   +11 more
core   +2 more sources

Copper- and Silver-Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five- and Six-Membered Heterocycles. [PDF]

Chemistry
This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
George J, Oh K.
europepmc   +2 more sources

Highly Substituted Medium-Sized Ring-Fused Azocinoquinoline Scaffolds by Post-Ugi-4CR Reductive Carbopalladation Cyclization

, 2019
A concise synthesis of quinoline-fused eight-membered rings from simple starting materials is described. Reductive cyclo-carbopalladation of suitable Ugi-4CR substrates as a key step leads to the regio- and diastereoselective formation of 1,2 ...
Frank Rominger (63178), Thomas J. J. Müller (7182779), Helya Janatian Ghazvini (7182776), Saeed Balalaie (1754095)   +3 more
core   +2 more sources

The Ugi-Smiles Reaction on Steroids: Discovery of Bioactive N,N-Disubstituted 3- Aminoestrones

, 2020
The Ugi-Smiles multicomponent reaction is a powerful tool for obtaining N-arylamines from acidic phenols and has been widely used for gaining access to structurally diverse scaffolds. In this work we demonstrate that this isocyanide-based coupling can be
Evelyn, Bonifazi, Javier Alberto, Ramirez, Cecilia, Attorresi, Bruno, Falcone, Gabriel, Gola, Andrea, Barquero   +5 more
core   +1 more source

Ugi Four-Component Reaction of Alcohols: Stoichiometric and Catalytic Oxidation/MCR Sequences

, 2013
A new, simple, and efficient procedure for the one-pot Ugi four-component reaction of alcohols instead of aldehydes is described. Using a stoichiometric amount of IBX or only 1-2% of sodium 2-iodobenzenesulfonate in the presence of Oxone, a wide range of
Drouet, Fleur, Masson, Géraldine, Zhu, Jieping   +2 more
core   +2 more sources