Results 11 to 20 of about 2,093 (93)

Synthesis of beta-lactam peptidomimetics through Ugi MCR: first application of chiral N-beta-Fmoc amino alkyl isonitriles in MCRs [PDF]

, 2011
Chiral N-beta-Fmoc amino alkyl isonitriles were employed in Ugi multi component reactions (Ugi 4C-3CR) to obtain functionalized beta-lactam peptidomimetics with L-aspartic acid alpha-methyl ester/peptide ester and organic aldehydes.
Narendra, N., Sureshbabu, V.V., Vishwanatha, T.M.   +2 more
core   +2 more sources

Diastereoselective three-component synthesis of beta-amino carbonyl compounds using diazo compounds, boranes, and acyl imines under catalyst-free conditions [PDF]

, 2014
Diazo compounds, boranes, and acyl imines undergo a three-component Mannich condensation reaction under catalyst-free conditions to give the anti β-amino carbonyl compounds in high diastereoselectivity.
Luan, Yi, Schaus, Scott E., Wang, Ge, Yu, Jie, Zhang, Xiaowei   +4 more
core   +1 more source

Direct polymerization of levulinic acid via Ugi multicomponent reactiont [PDF]

, 2016
A robust, direct and efficient approach has been developed for the utilization of levulinic acid (LevA) as a building block in the synthesis of polyamides.
Alonso, C. Remzi Becer, Chen, Deng, Dömling, Gangloff, Giovenzana, Giovenzana, Harriman, Isikgor, Jida, Kakuchi, Klingler, Kreye, Leibig, Lin, Manuel Hartweg, Mumm, Mäki-Arvela, Mülhaupt, Palkovits, Passerini, Rose, Rudick, Ruijter, Sehlinger, Sehlinger, Sehlinger, Sehlinger, Short, Solleder, Solleder, Thompson, Tye, Ugi, Ugi, Yang, Yang, Zhang   +38 more
core   +1 more source

Atomic mutagenesis of stop codon nucleotides reveals the chemical prerequisites for release factor-mediated peptide release. [PDF]

, 2018
Termination of protein synthesis is triggered by the recognition of a stop codon at the ribosomal A site and is mediated by class I release factors (RFs).
Clementi, Nina, Erlacher, Matthias David, Faserl, Klaus, Gasser, Catherina, Hoernes, Thomas Philipp, Hüttenhofer, Alexander, Joseph, Simpson, Juen, Michael Andreas, Kreutz, Christoph, Lindner, Herbert, Shi, Xinying, Willi, Jessica   +11 more
core   +3 more sources

Ionic-Liquid-Supported Synthesis of Amines and Derivatives [PDF]

, 2006
International audienceAmine precursors such as glycines protected at nitrogen with a Boc or formyl group were grafted by esterification on the hydroxylated arms of 1-(2-hydroxyethyl)-3-methylimidazolium hexafluorophosphates or tetrafluoroborates.
Bazureau, J.P., Debdab, Mansour, Mongin, Florence   +2 more
core   +4 more sources

Concise Synthesis of Macrocycles by Multicomponent Reactions [PDF]

, 2018
A short reaction pathway was devised to synthesize a library of artificial 18-27-membered macrocycles. The five-step reaction sequence involves ring opening of a cyclic anhydride with a diamine, esterification, coupling with an amino acid isocyanide ...
Abdelraheem, Eman M. M., Dömling, Alexander, Khaksar, Samad   +2 more
core   +2 more sources

Integrated Ugi-Based Assembly of Functionally, Skeletally, and Stereochemically Diverse 1,4-Benzodiazepin-2-ones [PDF]

, 2015
A practical, integrated and versatile U-4CR-based assembly of 1,4-benzodiazepin-2-ones exhibiting functionally, skeletally, and stereochemically diverse substitution patterns is described.
Abdelaziz El Maatougui, Armando Navarro-Vázquez, Armstrong R. W., Atkins R. J., Azuaje A., Baerends E. J., Bateson A. N., Belvisi L., Bolli M. H., Carlier P. R., Carlier P. R., Christian F. Masaguer, Cuny G., De Clerq E., De Silva R. A., Donald J. R., Dourlat J., Dömling A., Eddy Sotelo, Eichkorn K., Ettari R., Evans B. E., Gilman N. G., Gordon C. P., Guggenhem K. G., He P., Horton D. A., Hsu D. C., Huang Y., Jensen F., Jhonny Azuaje, José Carlos González-Gomez, José M. Pérez-Rubio, Keating T. A., Kleemann A., Kutzelnigg W., Lam P. C. H., Lecinska P., Linscheid P., Lodewyk M. W., Marcaccini S., Marcaccini S., Marta Teijeira, Micale N., Neese F., Petrovich A. G., Sañudo M., Schaefer A., Shaabani A., Shaabani A., Sinnecker S., Smith S. G., Smith S. G., Tempest P., Vicente Yaziji, Vı́ctor M. Sánchez-Pedregal, Weigend F., Xu J., Yang S. K., Zhang Y., Zhu J.   +60 more
core   +6 more sources

Synthesis of Boron-Containing Primary Amines [PDF]

, 2013
[[abstract]]In this study, boron-containing primary amines were synthesized for use as building blocks in the study of peptoids. In the first step, Gabriel synthesis conditions were modified to enable the construction of seven different aminomethylphenyl
Baxter, Bódis, Chia-Hua Tsai, Hara, Po-Shen Pan, Qian-Yu Hu, Sheng-Hsuan Chung, Ting-Ju Lin, Tripathi   +8 more
core   +2 more sources

Redox-mediated reactions of vinylferrocene: Toward redox auxiliaries [PDF]

, 2016
Chemical redox reactions have been exploited to transform unreactive vinylferrocene into a powerful dienophile for the Diels–Alder reaction and reactive substrate for thiol addition reactions upon conversion to its ferrocenium state.
Cooke, Graeme, Fitzpatrick, Brian, Long, De-Liang, Macgregor, Stuart A., Wiles, Alan A., Zhang, Xiaolu   +5 more
core   +1 more source

Synthesis of 5 H -Pyrrolo[3,4- b ]Pyridin-5-Ones via a Cerium Chloride Catalyzed Multicomponent Cascade Process: A One-Pot Approach Incorporating Ugi-Zhu 3CR, Aza Diels–Alder, N -Acylation, and Aromatization Reactions

Polycyclic Aromatic Compounds
We have synthesized α-isocyano-β-phenylpropionamides 5 (a–c) using a two-step process and then created a new series of poly-substituted 5H-pyrrolo[3,4-b]pyridin-5-ones 12 (a–o) via a multi-component reaction. Most of the reported literature used scandium triflate and either benzene or toluene as solvents, which are not good for the environment. We have
Ramasamy Duraisamy, M. B. Madhusudana Reddy, I. V. Asharani, Dhakshanamurthy Thirumalai   +3 more
openaire   +2 more sources