Results 21 to 30 of about 23,282 (131)

Direct synthesis of the arylboronic acid analogues of phenylglycine via microwave-assisted four-component Ugi reaction

, 2014
A four-component Ugi reaction (Ugi-4CR) utilizing formylphenyl boronic acids under mild condition was developed for the synthesis of arylboronic acid analogs.
Lian, Ru-Ching; Lin, Meng-Hsuan; Liao, Pin-Hsuan; Fu, Jia-Jie; Wu, Meng-Ju; Wu, Yang-Chang; Chang, Fang-Rong; Wu, Chin-Chung; Pan, Po-Shen, Pan, Po-Shen   +1 more
core   +1 more source

Novel postmodifications of the Ugi reaction [PDF]

, 2016
In dieser Arbeit wurden neuartige Postmodifikationen von Produkten der Ugi-4CR untersucht. Ihre Möglichkeiten und Grenzen wurden durch das Permutieren der notwendigen funktionellen Gruppen um das Ugi-Grundgerüst herum und durch Synthese von ...
Welsch, Sebastian
core   +1 more source

Innovations and Inventions: Why Was the Ugi Reaction Discovered Only 37 Years after the Passerini Reaction? [PDF]

, 2022
This year represents the 100th anniversary of the discovery of the Passerini three-component reaction. The related Ugi four-compound reaction was discovered 37 years after the Passerini reaction.
Dömling, Alexander, Alexander Dömling
core   +1 more source

Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings [PDF]

, 2017
An Ugi multicomponent reaction based two-step strategy was applied to generate medium-sized rings. In the first linear expansion phase, a series of diamines reacted with cyclic anhydrides to produce different lengths of terminal synthetic amino acids as ...
Eman M. M. Abdelraheem, Rossetti, Arianna, Arianna Rossetti, Dömling, Alexander, Shaabani, Shabnam, Abdelraheem, Eman M. M., Alexander Dömling, Kurpiewska, Katarzyna, Katarzyna Kurpiewska, Shabnam Shaabani, Abdelraheem, Eman M M, Madhavachary, Rudrakshula, Rudrakshula Madhavachary, Kalinowska-Tłuścik, Justyna, Justyna Kalinowska-Tłuścik   +14 more
core   +3 more sources

7,7′-(1,4-Phenylene)bis(2-benzyl-3-(3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one)

Molbank
The multicomponent synthesis of a novel and highly symmetric polyheterocycle based on the pyrrolo[3,4-b]pyridin-5-one core incorporating the privileged tetrahydroisoquinoline moiety is described.
Roberto E. Blanco-Carapia, Alejandro Islas-Jácome, Eduardo González-Zamora   +2 more
doaj   +1 more source

Ugi coupling reaction.

, 2016
The Ugi coupling reaction involves the combination of isocyanide (a), aldehyde (b), amine (c) and carboxylic acid (d) components in a single reaction step to give an α-aminoacyl amide product, as exemplified above for the preparation of AZ126.
Darren S. Heeke (3220149), Martin E. Cooper (2508670), Andrey Tovchigrechko (64098), Eileen Rao (48505), Jennifer C. Woo (707322), Neil Fraser (1840510), Sean K. Maynard (249632), Nicola Williams (565974), David Hornigold (3220152), Li Yu (81651), Sarah King (3220143), Jason D. Marshall (3220146), Christopher McCrae (1840507), Adeline M. Hajjar (127234)   +13 more
core   +1 more source

Sulfur-Switch Ugi Reaction for Macrocyclic Disulfide-Bridged Peptidomimetics [PDF]

, 2017
A general strategy is introduced for the efficient synthetic access of disulfide linked artificial macrocycles via a Ugi four-component reaction (U4CR) followed by oxidative cyclization.
Vishwanatha, Thimmalapura M, Thimmalapura M. Vishwanatha, Bergamaschi, Enrico, Dömling, Alexander, Alexander Dömling, Enrico Bergamaschi   +5 more
core   +1 more source

The Ugi reaction in polymer chemistry: syntheses, applications and perspectives

, 2015
The Ugi reaction, one of the most famous multicomponent reactions, has recently been introduced into polymer chemistry as a novel, efficient and useful tool to prepare multifunctional polymers.
Wei, Yen, Yang, Bin, Fu, Changkui, Tao, Lei, Zhao, Yuan   +4 more
core   +1 more source

'Atypical Ugi' tetrazoles [PDF]

, 2020
Amino acid-derived isocyano amides together with TMSN3, oxocomponents and 1° or 2° amines are common substrates in the Ugi tetrazole reaction. We surprisingly found that combining these substrates gives two different constitutional isomeric Ugi products ...
Abdelraheem, Eman M M, Dömling, Alexander, Goodwin, Imogen, Shaabani, Shabnam, Abdelraheem, Eman M. M., de Haan, Michel P., Kalinowska-Tłuścik, Justyna, Kurpiewska, Katarzyna, de Haan, Michel P   +8 more
core   +1 more source

Total Synthesis of Discobahamin A and Putative Structure of Discobahamin B via an Isocyanide‐based Macrocyclization Reaction

Angewandte Chemie, Volume 137, Issue 10, March 3, 2025.
An isocyanide‐based macrocyclization, involving the formation of a C(sp3)‐C(sp2) bond and the concurrent generation of an α‐acyloxy amide functional group, has been developed and successfully applied to the total synthesis of discobahamin A, a 24‐membered macrocyclopeptide. Abstract We report in this paper the first total synthesis of discobahamin A, a
Baochao Yang, Qian Wang, Jieping Zhu
wiley   +2 more sources