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CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.ABSTRACT This work aims to assess the S65487‐induced disruption of the B‐cell lymphoma‐2 (Bcl2)/Bcl2‐like protein 11 (Bim) complex at therapeutic doses via a pharmacokinetic/pharmacodynamic model and to reconcile pharmacokinetic data from microdoses and therapeutic doses in a single population pharmacokinetic model. The first model consists of a linear
Chloé Burlot +6 more
wiley +1 more source
Best Practices in Physiologically Based Pharmacokinetic (PBPK) Modeling
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling is a mechanistic cornerstone of model‐informed drug development (MIDD), providing evidence for regulatory decisions. PBPK models integrate physiological and pharmacological data and have been applied across a plethora of contexts of use, including assessing drug–drug interactions (DDIs ...
Marylore Chenel +6 more
wiley +1 more source
Genomic and Sex Contributions to Interindividual Variability in Pitavastatin Bioavailability
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.ABSTRACT Aim This study investigates pharmacogenetic determinants of pitavastatin disposition using a candidate‐gene approach. Methods In 48 healthy volunteers, 138 variants across 40 genes involved in drug metabolism and transport were analysed to assess their relationship with pitavastatin pharmacokinetics, alongside the influence of sex and ...
Eva González‐Iglesias +7 more
wiley +1 more source
Ontogenetic Sequence of Differential Gene Expression in Predator‐Induced Daphnia pulex
Molecular Ecology, Volume 35, Issue 13, July 2026.ABSTRACT In response to predators, many Daphnia species develop inducible morphological defenses. These traits are phenotypically plastic, meaning their production is suppressed in the absence of the predator. While previous studies have identified several neurohumoral factors and candidate genes involved in the development of the defenses, the ...
Andrey Rozenberg +5 more
wiley +1 more source
Únete a UGT : Únete a la jornada de acción sindical : tu participación es importante
, 2009 Informacions sobre la ...
Unió General de Treballadors (UGT)
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UGT informa : La ley básica de empleo de UCD : contra los parados
, 2009 Text ...
Unión General de Trabajadores (UGT)
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