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Pharmacogenetics, 2003
UDP-glucuronosyltransferases (UGTs) belong to a superfamily of microsomal enzymes responsible for glucuronidation of numerous endogenous and exogenous compounds including bilirubin, hormones, various drugs as well as environmental carcinogens. Glucuronidation predominantly serves as a pathway for elimination of the different glucuronidated compounds ...
Apurva A, Desai +2 more
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UDP-glucuronosyltransferases (UGTs) belong to a superfamily of microsomal enzymes responsible for glucuronidation of numerous endogenous and exogenous compounds including bilirubin, hormones, various drugs as well as environmental carcinogens. Glucuronidation predominantly serves as a pathway for elimination of the different glucuronidated compounds ...
Apurva A, Desai +2 more
openaire +2 more sources
Drug Metabolism and Disposition, 2007
5-(4'-Hydroxyphenyl)-5-phenylhydantoin (4'-HPPH), a major metabolite of phenytoin in human, is exclusively metabolized to a glucuronide. 4'-HPPH has a chiral center. (S)-4'-HPPH is a predominant form produced from phenytoin in humans, and (R)-4'-HPPH is an extremely toxic form with respect to gingival hyperplasia.
Miki, Nakajima +4 more
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5-(4'-Hydroxyphenyl)-5-phenylhydantoin (4'-HPPH), a major metabolite of phenytoin in human, is exclusively metabolized to a glucuronide. 4'-HPPH has a chiral center. (S)-4'-HPPH is a predominant form produced from phenytoin in humans, and (R)-4'-HPPH is an extremely toxic form with respect to gingival hyperplasia.
Miki, Nakajima +4 more
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Drug Metabolism and Pharmacokinetics, 2007
The interaction between cytochrome P450s (CYP, P450) and UDP-glucuronosyltransferases (UGTs) was studied by co-immunoprecipitation. P450 isoform-selective antibody was used as a probe to co-precipitate UGTs with the P450s from solubilized rat liver microsomes.
Yuji, Ishii +8 more
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The interaction between cytochrome P450s (CYP, P450) and UDP-glucuronosyltransferases (UGTs) was studied by co-immunoprecipitation. P450 isoform-selective antibody was used as a probe to co-precipitate UGTs with the P450s from solubilized rat liver microsomes.
Yuji, Ishii +8 more
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Verfahrensdokumentation für UGTS: Ungewissheitstoleranzskala
2002The UGTS with eight items for identifying how uncertain situations are evaluated allows the cross-divisional differentiation of persons based on their tolerance of uncertainty. Research on the tolerance of ambiguity or uncertainty goes back to Frenkel-Brunswik (1949). Reliability: Cronbach's alpha was alpha = .66-.72.
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2013
L’irinotecan a largement contribue aux importants progres realises ces quinze dernieres annees dans le traitement des cancers digestifs, et il occupe dorenavant une place majeure en cancerologie digestive. Developpe initialement dans le traitement du cancer colorectal avance pour lequel il est largement prescrit, l’irinotecan est egalement indique dans
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L’irinotecan a largement contribue aux importants progres realises ces quinze dernieres annees dans le traitement des cancers digestifs, et il occupe dorenavant une place majeure en cancerologie digestive. Developpe initialement dans le traitement du cancer colorectal avance pour lequel il est largement prescrit, l’irinotecan est egalement indique dans
openaire +1 more source