Results 131 to 140 of about 49,542 (253)

ZrO₂-Assisted QuEChERS-UHPLC-MS/MS for Simultaneous Determination of Four Aflatoxins in Cereals and Soybean Matrices. [PDF]

Toxins (Basel)
Liu S, Zheng X, Zhang S, Guo N, Zhang H, Shi J.   +5 more
europepmc   +1 more source

Phase I Metabolism of Novel Phencyclidine Derivative 3‐Cl‐PCP: In Vitro Studies With Pooled Human Liver Microsomes and Investigation of a Post‐Mortem Case

Drug Testing and Analysis, EarlyView.
A fatal 3‐chloro‐phencyclidine (3‐Cl‐PCP) intoxication was investigated by analyzing postmortem samples and a pooled human liver microsomes assay. Tentative metabolite identification was performed by liquid chromatography‐quadrupole time‐of‐flight mass spectrometry (LC‐QTOF‐MS). Seven phase I metabolites were identified.
Johannes Kutzler, Tobias Veit, Thomas Keller, Volker Auwärter   +3 more
wiley   +1 more source

From Activity Screening to Quality Control: UHPLC-MS/MS Analysis of Anti-Inflammatory Cyclodipeptides in <i>Pinellia ternata</i>. [PDF]

Molecules
Wang Y, Luo Y, Gan J, Wang L, Fang C, Zhang L, Zhen C, Chen B.   +7 more
europepmc   +1 more source

Exploring Cerumen as an Alternative Matrix for Drug Detection and Quantification: Method Development and Application in Clinical Samples

Drug Testing and Analysis, EarlyView.
An LC–MS/MS method was developed for the detection of 33 psychoactive medications in cerumen (earwax) and applied to the samples of 60 psychiatric inpatient volunteers. The findings highlighted the utility of cerumen as an innovative biospecimen in clinical toxicological analysis.
Dimitrios Phaedon Kevrekidis, Helen G. Gika, Georgios Panagiotoglou, Eleni Parlapani, Pavlos Pavlidis, Nikolaos Raikos   +5 more
wiley   +1 more source

Toxicokinetic-Oriented Assessment of Nepetalactone Using In Silico ADMET Modeling, In Vitro Rat and Human Liver Microsomes, and UHPLC-MS/MS Metabolite Characterization. [PDF]

Toxics
Stoica NB, Cascajosa-Lira A, Morea A, Catunescu GM, Hornedo-Ortega R, Guzmán-Guillén R.   +5 more
europepmc   +1 more source

Investigations Into the Metabolism and Elimination of Flmodafinil and Fladrafinil for Sports Drug Testing Purposes

Drug Testing and Analysis, EarlyView.
This article investigates the metabolism and elimination of flmodafinil and fladrafinil, two fluorinated analogs of modafinil and adrafinil listed as S6 stimulants by the World Anti‐Doping Agency. After single‐dose administration to six volunteers, the compounds and their main metabolites were studied in urine and blood.
O. Krug, S. Guddat, C. Görgens, K. Walpurgis, F. Toma, A. Thomas, M. Thevis   +6 more
wiley   +1 more source

A Method for Analysis of Free and Total Ropivacaine in Dog Plasma Using UHPLC-MS/MS. [PDF]

Biomed Chromatogr
Verdier N, Hummel K, Razzazi-Fazeli E.
europepmc   +1 more source

Determinación de oxilipinas mediante UHPLC-MS/MS

Departamento de Bioquímica y Biología Molecular y ...
openaire   +1 more source

In Vitro Metabolism of Δ8‐, Δ9‐, and Δ10‐THC in Human Hepatocytes: Distinct Δ10‐THC Biotransformation and Implications for Drug Testing

Drug Testing and Analysis, EarlyView.
Δ8‐THC and Δ9‐THC showed comparable metabolic profiles. In contrast, Δ10‐THC underwent extensive glucuronidation and hydroxylation, with only minor formation of a carboxy metabolite, indicating a markedly different metabolic pathway. These differences may increase the risk of misidentification and misinterpretation in cannabis drug testing.
Robert Kronstrand, Henrik Green, Markus Loh, Fabian Rüttimann, Manuela Carla Monti   +4 more
wiley   +1 more source

Investigations Into the Metabolism and Elimination of Tesofensine in Human Urine

Drug Testing and Analysis, EarlyView.
This study investigated tesofensine metabolism and urinary elimination after a single 483 μg intake via a dietary supplement. In six volunteers, urine was collected up to 659 h. LC‐HRMS/MS identified four tentative metabolites; maximum urinary concentrations reached 4 ng/mL within 4–48 h.
O. Krug, A. Thomas, M. Thevis
wiley   +1 more source