Results 191 to 200 of about 17,886 (241)

Deciphering the properties and reaction mechanism of anhydromevalonate phosphate decarboxylase, a prenylated flavin mononucleotide‐dependent enzyme in the archaeal mevalonate pathway

The FEBS Journal, EarlyView.
Characterization of anhydromevalonate phosphate decarboxylase, the UbiD‐family decarboxylase involved in the archaeal mevalonate pathway, was conducted. The enzyme is responsible for the biosynthesis of isoprenoids, such as archaeal membrane lipids, respiratory quinones, and dolichols.
Rino Ishikawa, Natsumi Matsushima, Soma Ishimine, Honoka Nakamoto, Hajime Hayakawa, Yoko Yasuno, Tetsuro Shinada, Hiroshi Kawaide, Tomokazu Ito, Hisashi Hemmi   +9 more
wiley   +1 more source

Comparative evaluation of noncanonical amino acids as site‐specific NMR probes for the complex of E. coli SSB with single‐stranded DNA without isotope labelling

The FEBS Journal, EarlyView.
Genetic encoding of noncanonical amino acids (ncAA) enables their site‐specific installation in proteins. This work compares the nuclear magnetic resonance (NMR) performance of different ncAAs in a large protein−DNA complex (~ 100 kDa) without isotope labelling. The ncAAs deliver readily detectable NMR signals in the complex between E.
Sreelakshmi Mekkattu Tharayil, Haocheng Qianzhu, Elwy H. Abdelkader, Adarshi P. Welegedara, Josemon George, Christoph Nitsche, Thomas Huber, Gottfried Otting   +7 more
wiley   +1 more source

A new approach in pediatric drug design : the development of a pediatric pig model, part II : the maturation of hepatic cytochrome P450 enzymes using enzyme activity and proteomics [PDF]

, 2017
Croubels, Siska, De Bock, Lies, Deforce, Dieter, Devreese, Mathias, Gasthuys, Elke, Millecam, Joske, Van Bocxlaer, Jan   +6 more
core   +1 more source

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

The FEBS Journal, EarlyView.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump, Leja Perne, Špela Koren, Eva Jarc Jovičić, Nastja Feguš, Carina Pinto Kozmus, Michele Wölk, Kristyna Brejchova, Maria Fedorova, Ondrej Kuda, Toni Petan   +10 more
wiley   +1 more source

A new branch of mammalian vitamin B6 metabolism: AKR1C‐mediated conversion of pyridoxal to pyridoxine and 4‐pyridoxolactone

The FEBS Journal, EarlyView.
Pyridoxal 5′‐phosphate (PLP) homeostasis relies on salvage enzymes, yet key metabolic branches remain undefined. We identify AKR1C isozymes as previously undescribed contributors that convert pyridoxal into pyridoxine or 4‐pyridoxolactone through reductase and dehydrogenase activities.
Nayu Kito, Yasuyuki Kitaura, Kyoka Iino, Kazuya Toriumi, Hyunah Noh, Naoya Ogawa, Makoto Arai, Hisashi Hemmi, Tomokazu Ito   +8 more
wiley   +1 more source

Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry

The FEBS Journal, EarlyView.
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero, Juan Luis Pacheco‐Garcia, Pavla Vankova, Dmitry Loginov, Isabel Quereda‐Moraleda, Jose Manuel Martin‐Garcia, Petr Man, Angel Luis Pey, Milagros Medina   +8 more
wiley   +1 more source

Lethal Effects of the Wild Potato Solanum bulbocastanum on the Planthopper Pentastiridius leporinus, a Vector of Bacterial Pathogens in Potato

Journal of Applied Entomology, EarlyView.
ABSTRACT The planthopper Pentastiridius leporinus [Hemiptera: Cixiidae] is a vector of the two plant pathogenic bacteria ‘Candidatus Arsenophonus phytopathogenicus’ and ‘Candidatus Phytoplasma solani’ causing ‘bacterial potato tuber wilt’ in potato.
Eva Therhaag, Karin Gorzolka, Jürgen Gross   +2 more
wiley   +1 more source

Multi‐omics analyses shed lights on the evolution and fruit development of Chinese raspberries (Rubus spp.)

Journal of Integrative Plant Biology, EarlyView.
High‐quality genomes of four wild raspberry species, analysis of their genetic relationships, identification of centromeres as markers for tracing their hybrid origins, exploration of fruit quality regulation, and discovery of a gene blocking anthocyanin transport and thus causing yellow fruits provides valuable resources for raspberry breeding ...
Ticao Zhang, Dengli Luo, Guodong Li, Huanchong Wang, Qiang Cao, Rengang Zhang, Yuran Li, Yingan Zhu, Chunhua Ma, Aaron Liston, Hang Sun, Qin Qiao   +11 more
wiley   +1 more source

Key metabolites secreted by Chlorella vulgaris alleviate salt stress in soybean seedlings

Journal of Integrative Plant Biology, EarlyView.
Chlorella vulgaris secretes exosome‐derived linolenic acid and inosine, which alleviate salt stress and enhance salt tolerance in soybean seedlings by activating stress‐responsive signaling networks. ABSTRACT Soil salinization is a major abiotic stress factor that reduces soybean production.
Yunyi Shi, Ruitong Chen, Kai Jiang, Aijuan Jiang, Jianchao Yang, Hongli Cui, Min Chen   +6 more
wiley   +1 more source

Does digestion of red meat cause more procarcinogenic DNA adducts in healthy subjects as opposed to white meat? [PDF]

, 2013
De Smet, Stefaan, Hemeryck, Lieselot, Moore, Sharon, Vanden Bussche, Julie, Vanhaecke, Lynn   +4 more
core   +1 more source