Results 41 to 50 of about 61,869 (301)

Data supporting the optimization of liquid chromatography tandem mass spectrometry conditions to analyze EPA-priority hormones and bisphenol A in water samples

Data in Brief, 2019
This database presents the optimization of ultra-high-performance liquid chromatography electrospray ionization tandem mass spectrometry (UHPLC-MS/MS) for the analysis of EPA-priority endocrine disruptor compounds (13 hormones and bisphenol A).
Ken Goeury, Sung Vo Duy, Gabriel Munoz, Michèle Prévost, Sébastien Sauvé   +4 more
doaj   +1 more source

Differences in the metabolite composition and mechanical properties of extracellular vesicles secreted by hepatic cellular models

Journal of Extracellular Vesicles, 2019
Liver constitutes the major metabolic factory in the organism and is involved in the synthesis, secretion and clearance of many blood-circulating molecules.
Felix Royo, David Gil-Carton, Esperanza Gonzalez, Justyna Mleczko, Laura Palomo, Miriam Perez-Cormenzana, Rebeca Mayo, Cristina Alonso, Juan M. Falcon-Perez   +8 more
doaj   +1 more source

A New Strategy for Efficient Retrospective Data Analyses for Designer Benzodiazepines in Large LC-HRMS Datasets

Frontiers in Chemistry, 2022
The expanding and dynamic market of new psychoactive substances (NPSs) poses challenges for laboratories worldwide. The retrospective data analysis (RDA) of previously analyzed samples for new targets can be used to investigate analytes missed in the ...
Meiru Pan, Brian Schou Rasmussen, Petur Weihe Dalsgaard, Christian Brinch Mollerup, Marie Katrine Klose Nielsen, Michael Nedahl, Kristian Linnet, Marie Mardal, Marie Mardal   +8 more
doaj   +1 more source

A Rapid Method for the Determination of Potassium Iodide in Ophthalmic Formulations by Indirect Derivatization with 4-Hydroxybenzoic Acid Using UHPLC–DAD and MS/MS Detection

Applied Sciences
A rapid ultra-high-performance liquid chromatography method with diode-array (DAD) and tandem mass spectrometric (MS/MS) detection was developed and, for the first time, applied for the determination of potassium iodide in ophthalmic formulations.
Jordan Sycz, Anna Duda-Madej, Antoni Szumny   +2 more
doaj   +1 more source

A single meal has the potential to alter brain oxylipin content. [PDF]

, 2020
Our objective was to determine whether consumption of a single meal has the potential to alter brain oxylipin content. We examined the cerebrum of mice fed a single high-fat/high-sucrose Western meal or a low-fat/low-sucrose control meal, as well as ...
Aung, HH, Norman, JE, Otoki, Y, Rutledge, JC, Taha, AY, Zhang, Z   +5 more
core   +1 more source

Genetic regulation of mouse liver metabolite levels. [PDF]

, 2014
We profiled and analyzed 283 metabolites representing eight major classes of molecules including Lipids, Carbohydrates, Amino Acids, Peptides, Xenobiotics, Vitamins and Cofactors, Energy Metabolism, and Nucleotides in mouse liver of 104 inbred and ...
Bennett, Brian J, Che, Nam, Ghazalpour, Anatole, Hagopian, Raffi, He, Aiqing, Kayne, Paul, Kirchgessner, Todd, Lusis, Aldons J, Orozco, Luz, Pan, Calvin, Shih, Diana, Yang, Wen-pin   +11 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A dried blood spot assay for paclitaxel and its metabolites [PDF]

, 2018
After being used for decades in clinical screening, dried blood spots (DBS) have recently received considerable attention for their application in pharmacokinetic and toxicokinetic studies in rodents. The goal of this study was to develop and apply a DBS-
Colin, Pieter, De Thaye, Elien, Van Bocxlaer, Jan, Vermeulen, An, Xie, Feifan   +4 more
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source