Results 51 to 60 of about 61,869 (301)

RIFAMPICIN: BIOTRANSFORMATION STUDY USING THE FUNGUS CUNNINGHAMELLA ELEGANS AND MONITORING THROUGH UHPLC-MS

Drug Analytical Research, 2020
Drug biotransformation studies appear as an alternative to pharmacological investigations of metabolites, development of new drug candidates with reduced investment and most efficient production.
Rafaela Sponchiado, Julia Sorrentino, Letícia M Cordenonsi, Alexandre M Fuentefria, Martin Steppe, Andreas Mendez, Cássia Virgínia Garcia   +6 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Optimization of QuEChERS cleanup for quantification of γ-oryzanol in vegetable oils by UHPLC-MS/MS

Food Chemistry: X
This study was based on QuEChERS cleanup coupled with UHPLC-MS/MS for the determination of γ-oryzanol compounds in vegetable oils. Several parameters of QuEChERS and UHPLC-MS/MS were studied for purification and detection of γ-oryzanol compounds in oil ...
Shaowei Li, Yuting Yuan, Liangxiao Zhang, Fei Ma, Peiwu Li   +4 more
doaj   +1 more source

Hierarchically Engineered Multi‐Enzyme Nanoreactors for in vitro Drug Biosynthesis and Pathway Transplantation Into Cells

Advanced Materials, EarlyView.
A hierarchically structured metal–organic framework (eMIL) is shown to host the complete six‐enzyme biosynthesis pathway for the anti‐cancer pigment violacein, reshaping reaction dynamics and multiplying in vitro yields. eMIL nanoreactors deliver this reconstituted bacterial multi‐protein system into mammalian cells, where cell‐derived substrates and ...
Ainur Sharip, Somayah S. Qutub, Manar M. Farooqui, Walaa Baslyman, Nida Khalfay, Lukman O. Alimi, Patricia Lopez Sanchez, Lingyun Zhao, Milena Chernyshevskaia, Giovanni Colombo, Niveen M. Khashab, Stefan T. Arold, Raik Grünberg   +12 more
wiley   +1 more source

Gut microbiota-derived propionate reduces cancer cell proliferation in the liver [PDF]

, 2012
Peer reviewedPublisher ...
A Everard, A M Neyrinck, AJ Brown, AS Neish, BF Hinnebusch, BL Pool-Zobel, C Cherbut, C Daubioul, C Sundstrom, E Le Poul, E M Dewulf, F Guarner, G G Muccioli, G Tolhurst, HS Taper, J Bray, J Busserolles, J C Martin, J Verrax, K P Scott, KM Maslowski, L B Bindels, LB Bindels, M Aoyama, M Montillo, MA Cox, MA Vinolo, N M Delzenne, NG Kondegowda, O Feron, P Buc Calderon, P D Cani, P Louis, P Porporato, P Sonveaux, P Sonveaux, PD Cani, PD Cani, R Alric, R Ren, S Siavoshian, T Lee, W Fiskus, Y Tang, Y Tang, Y Wang, YH Hong   +46 more
core   +1 more source

Inert Catalytic Sites Unlocked by Micropollutants for Rapid Water Decontamination with Near‐Complete Chemical Utilization

Advanced Materials, EarlyView.
Micropollutants can act as molecular triggers that activate a newly designed and chemically inert Fenton‐like PKU‐24 catalyst for on‐demand singlet oxygen generation from peroxymonosulfate (PMS), enabling nearly complete peroxide utilization and selective micropollutant removal from complex real‐world wastewater.
Yu‐Hang Li, Mingyi Liu, Yuanhao Li, Yaran Bai, Fu‐Xue Wang, Xiaoyi Hu, Xiaoguang Duan, Haodong Ji   +7 more
wiley   +1 more source

Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications. [PDF]

, 2015
Methylation of cytosine deoxynucleotides generates 5-methylcytosine (m(5)dC), a well-established epigenetic mark. However, in higher eukaryotes much less is known about modifications affecting other deoxynucleotides. Here, we report the detection of N(6)-
A Morgulis, Ana S H Costa, BA Braaten, BF Vanyushin, C Zang, Charles R Bradshaw, Christian Frezza, D Dominissini, D Roberts, E Ford, EL Greer, EM Reyes, EM Zdobnov, F Laengle-Rouault, G Bertani, G Zhang, GE Geier, George E Allen, H Kobayashi, H Li, J Boyes, JB Bowes, John B Gurdon, KS Pollard, L Micallef, M Lawrence, M Lu, Magdalena J Koziol, MG Marinus, MS May, PA Jones, PD Lawley, PD Thomas, PH Kay, RD Hotchkiss, S Ito, SE Luria, T Pfaffeneder, TL Bailey, TW Munns, U Gunthert, WA Cantara, WJ Kent, Y Fu, Y Gruenbaum   +44 more
core   +2 more sources

Detection of DNA Methylation in Genomic DNA by UHPLC-MS/MS

, 2020
DNA methylation serves to mark DNA as either a directed epigenetic signaling modification or in response to DNA lesions. Methods for detecting DNA methylation have become increasingly more specific and sensitive over time. Conventional methods for detecting DNA methylation, ranging from paper chromatography to differential restriction enzyme digestion ...
Konstantinos, Boulias, Eric Lieberman, Greer   +1 more
openaire   +3 more sources

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

The effect of Rosmarinus officinalis L infusion supplementation on blood pressure among healthy volunteers and grade 1 hypertensive patients

Phytomedicine Plus
Background: Rosmarinus officinalis L, has been traditionally used to manage various ailments. Preclinical trials have reported the antihypertensive effect of the bioactive compounds in rosemary.
Awatef Sassi, Aicha Laouani, Mohamed Aymen Ben Abdessalem, Imen Jarray, Hana Nasrallah, Farhana Ferdousi, Manel Nouira, Ali Mtiraoui, Abdallah Mahdhaoui, Hiroko Isoda, Saad Saguem   +10 more
doaj   +1 more source