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Current and future trends in UHPLC [PDF]

open access: yesTrAC - Trends in Analytical Chemistry, 2014
Abstract Since its commercial introduction in 2004, there has been a considerable interest in ultra-high-performance (pressure) liquid chromatography (UHPLC), which dramatically increases the throughput of regular HPLC methods. Although the ability to achieve fast separations and good resolution are the main drivers for the increasing use of UHPLC ...
Szabolcs Fekete   +2 more
exaly   +3 more sources
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Uhplc For The Separation of Proteins And Peptides

Bioanalysis, 2012
There is increasing interest within the pharmaceutical industry in the development of proteins and peptides as drugs in addition to their use as biomarkers. Immunochemistry-based techniques have been traditionally used for the quantitation of proteins and peptides; however, LC-MS-based methodologies are being increasingly adopted as they offer several ...
James W, Howard   +3 more
openaire   +2 more sources

The role of UHPLC in pharmaceutical development

Journal of Separation Science, 2007
AbstractPharmaceutical separations can be divided into three categories: high throughput, high productivity, and high resolution. These categories contain specific pharmaceutical applications, each of which has distinct separation goals. Traditionally, these goals have been achieved utilizing conventional HPLC with typical column dimensions and ...
Stephen M, Chesnut, John J, Salisbury
openaire   +2 more sources

UHPLC Quantification of Sotolon in White Wine

Journal of Agricultural and Food Chemistry, 2014
Sotolon (4,5-dimethyl-3-hydroxy-2,5-dihydrofuran-2-one) is a volatile compound involved in the atypical aging of dry white wine, causing an irreversible defect when it exceeds 7-8 μg L(-1), and it might be adopted as a chemical marker of oxidative aging.
M. Gabrielli, D. Fracassetti, A. Tirelli
openaire   +3 more sources

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