Results 91 to 100 of about 305,732 (287)

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Overall and non‐lung cancer incidence and mortality in the National Lung Screening Trial: Opportunities for multi‐cancer early detection

Cancer Medicine
Background Currently recommended cancer screening programs address only part of the overall population cancer burden. Even populations deemed high‐risk for certain individual cancers experience a considerable potential burden of other cancers.
Alpa V. Patel, Ellen T. Chang, Allan Hackshaw, Sam M. Janes, Diana S. M. Buist, Earl Hubbell, Christina A. Clarke, Graham A. Colditz   +7 more
doaj   +1 more source

Meta-analysis of defocus curves of monofocal, enhanced monofocal and extended depth of focus IOLs

BMJ Open Ophthalmology
Background/aims Recently, modified monofocal intraocular lenses (IOLs) (proposed mono plus IOLs) have emerged claiming to provide monofocal quality distance vision while enhancing intermediate distance visual performance. The purpose of this study was to
Sathish Srinivasan, Cyril Nyankerh, Jessie Hull, Rajaraman Suryakumar   +3 more
doaj   +1 more source

Caloric vestibular stimulation for the management of motor and non-motor symptoms in parkinson's disease: Intention-to-treat data

Data in Brief, 2019
This report provides data related to the safety and effectiveness of repeated time-varying caloric vestibular stimulation (CVS) as a treatment for motor and non-motor features of Parkinson's disease (PD).
David Wilkinson, Aleksandra Podlewska, Sarah E. Banducci, Tracy Pellat-Higgins, Martin Slade, Mayur Bodani, Mohamed Sakel, Lanty Smith, Peter LeWitt, Kristen Ade   +9 more
doaj   +1 more source

A Dual‐Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor‐Associated Osteolysis Restoration via Sequential Release

Advanced Science, EarlyView.
The versatile CaO2@CuMOF@HAP nanohybrid demonstrates an outstanding MMP9/pH‐triggered release performance for sequential release of osteogenic growth peptide into deep‐seated tumor‐infiltrated bone destruction areas and dual ions into tumor cells, enabling efficient tumor‐associated osteolysis restoration and tumor elimination for more comprehensive ...
Lan Liu, Han‐Zhe Liu, Zhe‐Nan Liu, Tong Wang, Li‐Li Yu, Qiu‐Jing Li, Zi‐Yi Chen, Guo‐Feng Luo, Zheng‐Jun Shang   +8 more
wiley   +1 more source

Safety and immunogenicity of DNA omicron booster Alveavax-v1.2 in Ad26.COV2.S-vaccinated adults

iScience
Summary: A phase I study assessed the safety and immunogenicity of the naked DNA Omicron BA.2 booster vaccine, Alveavax-v1.2, in 130 South African adults previously vaccinated with Janssen Ad26.COV2.S. Participants received varying doses intradermally or
Maximilian Schons, Tobias Odendahl, James A. Smith, Kyle Fish, Anemone Franz, Miti Saksena, Sonia Sutherland, Vaughan Reed, Phumzile Mhlongo, Madeli Kruger, Zinhle Zwane, Kgoete Dimakatso, Carol Crowther, Penny Moore, Veronique De Jager, Ethan Alley, Grigory Khimulya   +16 more
doaj   +1 more source

Decoding the Cardiac Immune Microenvironment and Fibroblast Crosstalk in Radiotherapy Combined with Immunotherapy‐Induced Cardiac Fibrosis Based on Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo, Ying Yu, Zhimin Zeng, Yanxin Chen, Yali Yi, Zhiqin Lu, Fujuan Zeng, Peng Xu, Daya Luo, Leifeng Chen, Anwen Liu   +10 more
wiley   +1 more source

Bifidobacterium animalis Subspecies lactis CECT 8145 Affects Markers of Metabolic Health in Dogs During Weight Gain and Weight Loss

Animals
This study explored the effects of Bifidobacterium animalis subspecies lactis CECT 8145 (B. animalis CECT 8145)—in both live probiotic and heat-treated postbiotic form—on metabolic health and digestion in male and female Labrador Retrievers during weight
Sarah M. Dickerson, Claire L. Timlin, Fiona B. Mccracken, Patrick Skaggs, Sophie L. Nixon, Richard Day, Craig N. Coon   +6 more
doaj   +1 more source

Combining the Pitcher and Lotus Plant: Supericephobic and Superhydrophobic Silicone Films

Advanced Science, EarlyView.
Based on bench‐top nanomolding of polydimethylsiloxane (PDMS) with optimized silicone oil content, we developed hierarchically structured silicone films by essentially combining the properties of the lotus and pitcher plant; particularly we are able to achieve water contact angle as high as 171° and ice adhesion strength as low as 11.5 kPa (i.e ...
Cliff L. W. Ng, Joshua Ham, Sanpreet Kaur, Clayton W. Schultz, Hua‐Zhong Yu   +4 more
wiley   +1 more source

Current Knowledge and Attitudes Concerning Cost-Effectiveness in Glaucoma Pharmacotherapy: A Glaucoma Specialists Focus Group Study. [PDF]

, 2020
Background:Rising healthcare costs motivate continued cost-reduction efforts. To help lower costs associated with open-angle glaucoma (OAG), a prevalent, progressive disease with substantial direct and indirect costs, clinicians need to understand the ...
Cioffi, George A, Feldman, Robert M, Feldman, Robert M, Liebmann, Jeffrey M, Weinreb, Robert N   +4 more
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