Results 131 to 140 of about 305,732 (287)

Advancing Pharmacometrics in Africa: Insights and Perspectives From the 2025 Pharmacometrics Africa Conference

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacometrics (PMX) in Africa has transitioned from foundational capacity‐building to job creation, scientific leadership, regulatory influence, and health innovation. To accelerate this progress, the 2025 Pharmacometrics Africa Conference (PMXAC‐2025) convened key stakeholders to consolidate the continental PMX community, review progress in local ...
Babatunde Ayodeji Adeagbo, Innocent Gerald Asiimwe, Linda Chaba, Aida N. Kawuma, Francis Williams Ojara, Ochuko Maureen Orherhe, Simon Peter Asiimwe, Veshni Pillay‐Fuentes Lorente, Sharon Sawe, Cassius M. Phogole, Catriona Waitt, Samer Mouksassi, Goonaseelan (Colin) Pillai   +12 more
wiley   +1 more source

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

Clinical Pharmacology &Therapeutics, EarlyView.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer, Ellen Cannady, Filip Cuyckens, Ulrike Glaenzel, Camille Granvil, Felix Huth, Alexander D. James, Wenying Li, Céline Veau, Graeme Young, Qin Yue, Gregory S. Walker, Upendra A. Argikar, Jonathan N. Bauman, Cathy Cantalloube, Yu‐Luan Chen, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Simone Schadt, Hanno Schieferstein, Julia Suchomel, Shuai Wang, S. Cyrus Khojasteh   +24 more
wiley   +1 more source

The role of community partners in urban investments [PDF]

Institutional investors seeking to deploy capital to underserved areas do not have either the time or the expertise to actively manage these specialized investments.
Anna Steiger, Lisa Hagerman, Tessa Hebb
core  

Empowering teachers and fostering pupil climate action in Welsh primary schools

The Curriculum Journal, EarlyView.
Abstract The Curriculum for Wales intends to help students understand and address climate change, but relies on teachers' knowledge and implementation thereof. This article focuses on “The Lifecycle of My Clothes”, a unit of work (UoW) developed by academics and practitioners. The UoW aimed to increase students' awareness of the environmental impact of
Jennifer A. Rudd, Shannon R. O'Connor, Geraldine Lublin   +2 more
wiley   +1 more source

A tutorial for model‐based evaluation and translation of cardiovascular safety in preclinical trials

CPT: Pharmacometrics & Systems Pharmacology
Assessment of drug‐induced effects on the cardiovascular (CV) system remains a critical component of the drug discovery process enabling refinement of the therapeutic index. Predicting potential drug‐related unintended CV effects in the preclinical stage
Victoria Kulesh, Igor Vasyutin, Alina Volkova, Kirill Peskov, Holly Kimko, Victor Sokolov, Ravindra Alluri   +6 more
doaj   +1 more source

Membrane Engineering for Battery Systems: Bridging Design Principles and Frontier Applications

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
The review emphasizes membrane separators' role in battery performance and safety, covering redox flow, lithium‐ion, and solid‐state batteries. It reviews advances in membrane materials (e.g., polymer electrolytes, hybrid composites) and ion transport mechanisms, while addressing challenges like dendrite growth and crossover losses.
Xiaoqun Zhou, Justice Delali Akoto, Rui Tan, Jun Ma   +3 more
wiley   +1 more source

Defect Engineering and Effect of Vacancy Concentration on the Electrochemical Performance of V‐Based MXenes

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Using a top‐down defect engineering approach, controllable vacancy concentrations are introduced into V‐based MXenes by rationally designing the precursor MAX phase, aiming to investigate the effect of vacancy concentration on the electrochemical performance.
Leiqiang Qin, Rutuparna Samal, Jianxia Jiang, Joseph Halim, Ningjun Chen, Florian Chabanais, Per O. A. Persson, Johanna Rosen   +7 more
wiley   +1 more source

The In Vitro Transgenic Rodent Assay in Primary MutaMouse Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the HPRT Gene

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Gene mutations can be detected in mammalian cells in vitro using indicator genes such as the hypoxanthine‐guanine‐phosphoribosyltransferase (HPRT) gene. These assays have been adopted as OECD test guidelines (TG, e.g., OECD TG no. 476) and are used for regulatory purposes.
Alina Göpfert, Kylee Kendra Marie Ronnenberg, Claudia Ruelker, Silke Spang, Naveed Honarvar, Robert Landsiedel   +5 more
wiley   +1 more source

Calcitonin gene‐related peptide concentration in cerebrospinal fluid and serum in horses affected by trigeminal‐mediated headshaking

Equine Veterinary Journal, EarlyView.
Abstract Background Trigeminal‐mediated headshaking (TMHS) in horses shares clinical features with human trigeminal neuralgia (HTN). Increased levels of the neuropeptide calcitonin gene‐related peptide (CGRP) have been found in the blood and cerebrospinal fluid (CSF) of HTN patients. Inhibition of CGRP in humans has shown promise for pain relief.
Lisa Annabel Weber, Hilke Oltmanns, Ludovica Chiavaccini, Kirstie J. Pickles, Veronica Roberts, Tanja Kloock, Tobias Niebuhr, Karsten Feige   +7 more
wiley   +1 more source

Finalisation of the European Approach to Assess the Fire Performance of Facades—Brief Information on the Outcome of the Project

Fire and Materials, EarlyView.
ABSTRACT This research was conducted within the framework of project SI2.825082, funded by the European Commission—DG GROW. The project's objective was to finalise a European approach for assessing the fire performance of façades under medium and large fire exposure conditions.
Péter Tóth, Anja Hofmann‐Böllinghaus, Fabien Dumont, Johan Anderson, Johan Sjöström, Mikael Bergius, Roman Chiva, Octavian Lalu   +7 more
wiley   +1 more source