Results 41 to 50 of about 10,812,709 (214)

The UK Longitudinal Linkage Collaboration: the UK's national Trusted Research Environment for the longitudinal research community.

The UK Longitudinal Linkage Collaboration (LLC) is the national Trusted Research Environment (TRE) for the centralised curation and integration of UK Longitudinal Population Studies’ (LPS) data and the systematic linkage of participants’ routine health, administrative and environmental records.
Boyd, Andy, Flaig, Robin, Oakley, Jacqui, Evans, Katharine, Thomas, Richard, Campbell, Kirsteen, Calkin, Rachel, Hill, Abigail, McLachlan, Stela, Turner, Emma   +9 more
openaire   +1 more source

EndoTac: An Endoscopic Camera‐Based Tactile Sensor with High Sensitivity for Minimally Invasive Surgery

Advanced Science, EarlyView.
EndoTac presents a trocar‐compatible endoscopic vision‐based tactile sensor that uses a convex mirror to enlarge side‐facing tactile coverage during minimally invasive vessel palpation. Distorted tactile images are unwarped and processed by a learning model to estimate vascular deformation, enabling sensitive, spatially distributed tactile perception ...
Yupeng Wang, Nicolas Raison, Xuyang Zhang, Aijia Yang, Lukas Lindenroth, Shan Luo   +5 more
wiley   +1 more source

Iron‐Tannic Acid Hydrogel Mediated Mild Photothermal Therapy Combined With Ferroptosis Enhances Anti‐Tumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An injectable gelatin‐based tannic acid–iron hydrogel with mild photothermal therapy could not only induce immunogenic cell death, but also elicit ferroptosis of both tumor cells and tumor‐associated macrophages, resulting in DC maturation, T‐cell infiltration and down‐regulation of ferroptosis‐sensitive M2‐type TAMs levels.
Yuan Zhu, Xi Yu, Tao Wang, Wanyi Liu, Chang Lu, Jiani Zhong, Yujie He, Wei Li, Kunxi Zhang, Peihao Yin, Zeting Yuan   +10 more
wiley   +1 more source

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source

Change in alcohol outlet density and alcohol-related harm to population health (CHALICE)

BMC Public Health, 2012
Background Excess alcohol consumption has serious adverse effects on health and violence-related harm. In the UK around 37% of men and 29% of women drink to excess and 20% and 13% report binge drinking.
Fone David, Dunstan Frank, White James, Webster Chris, Rodgers Sarah, Lee Shin, Shiode Narushige, Orford Scott, Weightman Alison, Brennan Iain, Sivarajasingam Vas, Morgan Jennifer, Fry Richard, Lyons Ronan   +13 more
doaj   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Baseline characteristics of UK Biobank (all), Welsh UK Biobank participants (with UK Biobank, primary and secondary care data linkage), and CPRD (primary and secondary care data linkage).

, 2016
Baseline characteristics of UK Biobank (all), Welsh UK Biobank participants (with UK Biobank, primary and secondary care data linkage), and CPRD (primary and secondary care data linkage).
Sinead Brophy (40627), Mark Atkinson (165217), Nishi Chaturvedi (130777), Rohini Mathur (3122613), Naomi Allen (140094), Sophie V Eastwood (3122607), Simon de Lusignan (2416), Cathie Sudlow (259959), Robin Flaig (3122610)   +8 more
core   +1 more source

The Academic Backbone: longitudinal continuities in educational achievement from secondary school and medical school to MRCP(UK) and the specialist register in UK medical students and doctors. [PDF]

, 2013
Selection of medical students in the UK is still largely based on prior academic achievement, although doubts have been expressed as to whether performance in earlier life is predictive of outcomes later in medical school or post-graduate education. This
Paice, E., Jane Dacre, Woolf, K, Dacre, J., Elisabeth Paice, IC McManus, McManus, I, Dacre, J, Chris Dewberry, Katherine Woolf, Dewberry, Chris, McManus, I.C., Dewberry, C, Woolf, K., Paice, E   +14 more
core   +2 more sources

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

ADRUK Ingest Improvement Task and Finish Group: Smoothing the ingest of data

International Journal of Population Data Science
Objectives Analysts ingest data to TREs for research; extract, process and curate public sector data then made accessible to researchers in safe environments. Although differences surround each dataset, the processes can be made broadly replicable.
Jen Bishop, Linus Chirchir, Rachel Coey, Amy Dunlop, Hywel Evans, David Grzybowski, Alan Harbinson, Cristina Magder, Nichola McCullough, Richard McFerran, Jen Muir, Alex Ramage, Stella Telford, Richard Thomas, Tudor Vilcan   +14 more
doaj   +1 more source