Results 31 to 40 of about 359,193 (314)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

‘The Expedition to China’: Corruption and Shaping of British Pacific Policy in the Early-to-Mid Nineteenth Century

open access: yesOriental Studies
Introduction. The paper examines some features inherent to the shaping of Britain’s Pacific policy throughout the early-to-mid nineteenth century in China.
Olga Yu. Zhukovets   +2 more
doaj   +1 more source

A Different Approach to Legislative Bodies: Reflections on the History of Parliament Oral History Project and Laws Around Abortion

open access: yesRechtsgeschichte - Legal History, 2021
The History of Parliament Oral History Project has been interviewing former Members of the UK Parliament since 2011. Life stories from inside Parliament reveal missing information about personal motivations, informal cross-party collaboration and use ...
Emma Peplow, Priscilla Pivatto
doaj  

A saída do Reino Unido da União Europeia. Um acordo tirado a ferros

open access: yesRevista Crítica de Ciências Sociais, 2021
The article examines the withdrawal agreement between the UK and the EU following the Brexit referendum including an analysis of the role of the main political actors.
António Goucha Soares
doaj   +1 more source

The European Parliament and the UK’s renegotiation: what do MEPs think? Part II [PDF]

open access: yes, 2016
Debates about the future of UK-EU relations have paid little attention to the European Parliament. There have been no studies comparable to those that have looked into how member states view the renegotiation or might respond to a Brexit.
Hübner, Danuta   +3 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The macroeconomic consequences of Scottish fiscal autonomy: inverted haavelemo effects in a general equilibrium analysis of the tartan tax [PDF]

open access: yes, 2007
In 1997 the Scottish people voted both for the creation of a legislative Parliament and to endow the Parliament with tax-varying powers. The establishment of the Scottish Parliament in 2000 heralded the most radical innovation in the regional fiscal ...
McGregor, Peter G.   +2 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Assessing What Brexit Means for Europe: Implications for EU Institutions and Actors

open access: yesPolitics and Governance, 2021
With the signing of the EU–UK trade and cooperation agreement in December 2020, the configurations of Brexit have started to become clearer. The first consequences of the UK’s decision to leave the EU have become visible, both in the UK and in the EU ...
Edoardo Bressanelli, Nicola Chelotti
doaj   +1 more source

UK-Rwanda Deal Pushed Through Parliament [PDF]

open access: yes
Völkerrechtsblog
Provan, Jack, Grünhagen, Nadine
openaire   +1 more source

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