Results 31 to 40 of about 7,857,664 (291)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

‘The Expedition to China’: Corruption and Shaping of British Pacific Policy in the Early-to-Mid Nineteenth Century

Oriental Studies
Introduction. The paper examines some features inherent to the shaping of Britain’s Pacific policy throughout the early-to-mid nineteenth century in China.
Olga Yu. Zhukovets, Elena K. Sklyarovа, Madinat A.Gutieva   +2 more
doaj   +1 more source

Lessons for Tuberculosis from scrutiny of HIV/AIDS and Malaria UK Parliamentary Questions

International Journal of Infectious Diseases, 2015
Objectives: To identify whether parliamentary scrutiny, in the form of Written Parliamentary Questions (WPQs), has any significant impact on the UK government's stated aid priorities and whether, by refining the approach that MPs with an interest in TB ...
Matt Oliver, Gillian M. Craig, Alimuddin Zumla   +2 more
doaj   +1 more source

Practical implementation of CRD III remuneration rules in the UK - issues and results [PDF]

, 2012
Professor Kern Alexander's report on the UK's regulation of banker's bonuses to the European Parliament on 30 January 2012. In the report, he argues for amending the EU Capital Requirements Directive's (CRD III) prescriptive approach for regulating ...
Alexander, Kern
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A saída do Reino Unido da União Europeia. Um acordo tirado a ferros

Revista Crítica de Ciências Sociais, 2021
The article examines the withdrawal agreement between the UK and the EU following the Brexit referendum including an analysis of the role of the main political actors.
António Goucha Soares
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The Timing and Strength of Inequality Concerns in the UK Public Debate: Google Trends, Elections and the Macroeconomy

Economies
Inequality among people has several unwanted effects, in humanistic, social and economic contexts. Several studies address distributional preferences among groups, but little is known about when inequality issues are focused and when and why inequality ...
Knut Lehre Seip, Frode Eika Sandnes
doaj   +1 more source

Assessing What Brexit Means for Europe: Implications for EU Institutions and Actors

Politics and Governance, 2021
With the signing of the EU–UK trade and cooperation agreement in December 2020, the configurations of Brexit have started to become clearer. The first consequences of the UK’s decision to leave the EU have become visible, both in the UK and in the EU ...
Edoardo Bressanelli, Nicola Chelotti
doaj   +1 more source