Results 31 to 40 of about 25,886 (305)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Oriental StudiesIntroduction. The paper examines some features inherent to the shaping of Britain’s Pacific policy throughout the early-to-mid nineteenth century in China.
Olga Yu. Zhukovets +2 more
doaj +1 more source
Rechtsgeschichte - Legal History, 2021 The History of Parliament Oral History Project has been interviewing former Members of the UK Parliament since 2011. Life stories from inside Parliament reveal missing information about personal motivations, informal cross-party collaboration and use ...
Emma Peplow, Priscilla Pivatto
doaj
A saída do Reino Unido da União Europeia. Um acordo tirado a ferros
Revista Crítica de Ciências Sociais, 2021 The article examines the withdrawal agreement between the UK and the EU following the Brexit referendum including an analysis of the role of the main political actors.
António Goucha Soares
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
UK-Rwanda Memorandum of Understanding Written Evidence [PDF]
, 2022 This written evidence is primarily concerned with the question of whether the UK can externalise its obligations under the 1951 Refugee Convention (as amended by the 1967 Protocol) by outsourcing refugee status determination to Rwanda.
Boase, M.
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Assessing What Brexit Means for Europe: Implications for EU Institutions and Actors
Politics and Governance, 2021 With the signing of the EU–UK trade and cooperation agreement in December 2020, the configurations of Brexit have started to become clearer. The first consequences of the UK’s decision to leave the EU have become visible, both in the UK and in the EU ...
Edoardo Bressanelli, Nicola Chelotti
doaj +1 more source
Visions of EU Reform - The Irish Perspective [PDF]
, 2015 The evidence submission to the House of Lords EU Select Committee Visions of EU Reform Inquiry focuses on the extent to which the Irish Government shares the UK Government’s vision for the future of Europe (as part of the current UK-EU membership ...
O'Mahony, Jane
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