Results 41 to 50 of about 359,193 (314)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The Timing and Strength of Inequality Concerns in the UK Public Debate: Google Trends, Elections and the Macroeconomy

Economies
Inequality among people has several unwanted effects, in humanistic, social and economic contexts. Several studies address distributional preferences among groups, but little is known about when inequality issues are focused and when and why inequality ...
Knut Lehre Seip, Frode Eika Sandnes
doaj   +1 more source

The Lobbying Bill is a missed opportunity [PDF]

, 2013
In response to recent lobbying scandals, the government has introduced the Transparency of Lobbying, Non-party Campaigning and Trade Union Administration Bill, which had its first reading in Parliament earlier this month.
Barrington, Robert
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

The British parliament: An effort towards the constitutional reform [PDF]

Zbornik Radova Pravnog Fakulteta u Nišu, 2015
The British Parliament is the eldest representative assembly which inspired the development of most European parliamentary systems. This institution provides a framework for the Westminster model of democracy.
Pejić Irena
doaj   +1 more source

Prevalence and incidence of alcohol dependence: cross-sectional primary care analysis in Liverpool, UK

BMJ Open, 2023
Objectives Liverpool has high prevalence of alcohol use disorders (AUDs) compared with the rest of the UK. Early identification and referral in primary care would improve treatment for people with AUD.
Andrew Jones, Pooja Saini, Lynn Owens, Ryan Young, Catharine Montgomery, Christine Schoetensack, Nadja Van Ginneken, Melissa Rice   +7 more
doaj   +1 more source

Analysis of UK Parliament Web Sites for Disability Accessibility [PDF]

, 2009
The growth of the Internet has led to an increase in the number of public services offered by U.K. government entities on their Web sites. A variety of consumers use e-government sites, and those individuals with disabilities are guaranteed the same ...
Kuzma, Joanne, Price, Colin
core   +1 more source

How did a lower drink‐drive limit affect bar trade and drinking practices?:A qualitative study of how alcohol retailers experienced a change in policy [PDF]

, 2019
Introduction and Aims Reducing the legal drink-drive limit from 0.08% to 0.05% blood alcohol concentration (BAC) can reduce road traffic accidents and deaths if properly enforced.
Giles L, Killoran AA, National Transport Commission, North P, Solomon RM, The UK Parliament, Willoughby L, World Health Organisation   +7 more
core   +6 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Devolution, the Independence Referendum and Votes at 16 in Scotland: Holyrood, a Pioneer in Democracy Leading the Way for Westminster?

Revue Française de Civilisation Britannique, 2019
The Scottish Parliament enfranchised 16 and 17-year-olds prior to the 2014 referendum on independence of Scotland from the UK. Scotland was among the very first nations in the world to lower the minimum voting age below 18.
Sarah Pickard
doaj   +1 more source