Results 91 to 100 of about 499,883 (421)

Vedolizumab as induction and maintenance therapy for ulcerative colitis.

New England Journal of Medicine, 2013
BACKGROUND Gut-selective blockade of lymphocyte trafficking by vedolizumab may constitute effective treatment for ulcerative colitis. METHODS We conducted two integrated randomized, double-blind, placebo-controlled trials of vedolizumab in patients ...
B. Feagan, P. Rutgeerts, B. Sands, S. Hanauer, J. Colombel, W. Sandborn, G. Van Assche, J. Axler, Hyo-Jong Kim, S. Danese, I. Fox, C. Milch, S. Sankoh, T. Wyant, Jing Xu, A. Parikh   +15 more
semanticscholar   +1 more source

Application of clinical indexes in ulcerative colitis patients in regular follow-up visit. correlation with endoscopic 'mucosal healing' and implication for management [PDF]

, 2015
OBJECTIVE: Ulcerative Colitis (UC) is a chronic inflammatory disease of the colon of unknown etiology. Several clinical indexes have been proposed for UC disease activity evaluation, but none have been properly validated.
Corleto, Vito Domenico, D'Ambra, Giancarlo, Delle Fave, G., Delle Fave, M. M., DI GIULIO, Emilio, Festa, S., Menasci, F., Pagnini, C., Rizzatti, G.   +8 more
core  

Mechanisms of Baicalin Alleviates Intestinal Inflammation: Role of M1 Macrophage Polarization and Lactobacillus amylovorus

Advanced Science, EarlyView.
Baicalin alleviates E. coli‐induced intestinal inflammation through dual mechanisms: direct inhibition of the TLR4/IRF/STAT signaling pathway to modulate macrophage polarization and antigen presentation, thereby regulating Th17/Treg cell differentiation; and microbiota‐mediated indirect effects via increasing Lactobacillus amylovorus abundance and ...
Shunfen Zhang, Ruqing Zhong, Miao Zhou, Kai Li, Huiyuan Lv, Huixin Wang, Ye Xu, Dadan Liu, Qiugang Ma, Liang Chen, Hongfu Zhang   +10 more
wiley   +1 more source

Integrated bioinformatics and network pharmacology to identify the therapeutic target and molecular mechanisms of Huangqin decoction on ulcerative Colitis

Scientific Reports, 2022
Huangqin decoction (HQD) is a Traditional Chinese Medicine formula for ulcerative colitis. However, the pharmacology and molecular mechanism of HQD on ulcerative colitis is still unclear.
Yi Wu, Xinqiao Liu, Guiwei Li
doaj   +1 more source

Deep Bayesian Active-Learning-to-Rank for Endoscopic Image Data [PDF]

arXiv, 2022
Automatic image-based disease severity estimation generally uses discrete (i.e., quantized) severity labels. Annotating discrete labels is often difficult due to the images with ambiguous severity. An easier alternative is to use relative annotation, which compares the severity level between image pairs.
arxiv  

Performance of a Deep Learning Model vs Human Reviewers in Grading Endoscopic Disease Severity of Patients With Ulcerative Colitis

JAMA Network Open, 2019
Key Points Question What is the agreement of automatically determined endoscopic severity of ulcerative colitis using deep learning models compared with expert human reviewers? Findings In this diagnostic study including colonoscopy data from 3082 adults,
R. Stidham, Wenshuo Liu, S. Bishu, Michael D. Rice, P. Higgins, Ji Zhu, B. Nallamothu, A. Waljee   +7 more
semanticscholar   +1 more source

Clinical Features and Risk Factors of Autoimmune Liver Involvement in Pediatric Inflammatory Bowel Disease [PDF]

, 2016
OBJECTIVES:Autoimmune liver disease is reported in up to 7.8% of children with inflammatory bowel disease. A distinct inflammatory bowel disease phenotype has been suggested in adults and in small pediatric cohorts.
Alexopoulou, Alvarez, Block, Boonstra, Deneau, Dotson, Faubion, Feldstein, Goyal, Gregorio, Halliday, Hirschfield, Hov, Jose, Jose, Levine, Levine, Liberal, Loftus, Loftus, Lundqvist, Maggiore, Malaty, Mieli-Vergani, Navaneethan, Noble-Jamieson, Olsson, Ordonez, Penna, Rönnblom, Sokol, Zholudev   +31 more
core   +1 more source

AhR‐Dependent Induction of β‐Defensin 1 in Colonic Epithelial Cells Regulates Cross‐Talk between Gut Microbiota and Immune Response Leading to Attenuation of Colitis

Advanced Science, EarlyView.
This study identifies a key signaling pathway involving the environmental sensor AhR and antimicrobial peptides, such as BD‐1, in the regulation of intestinal homeostasis. It highlights the role of BD‐1 in regulating gut microbiota and the intestinal immune response.
Manikandan Palrasu, Amarnath Marudamuthu, Khadija Kakar, Hamida Hamida, Shruthi Thada, Rohan Gupta, Kiesha Wilson, Taylor Carter, Yin Zhong, Archana Saxena, Xiaoming Yang, Narendra Singh, Philip Brandon Busbee, Jie Li, Monica Garcia‐Buitrago, Prakash Nagarkatti, Mitzi Nagarkatti   +16 more
wiley   +1 more source

Disease Severity Regression with Continuous Data Augmentation [PDF]

arXiv, 2023
Disease severity regression by a convolutional neural network (CNN) for medical images requires a sufficient number of image samples labeled with severity levels. Conditional generative adversarial network (cGAN)-based data augmentation (DA) is a possible solution, but it encounters two issues.
arxiv  

Neutrophil Extracellular Traps Sustain Inflammatory Signals in Ulcerative Colitis.

Journal of Crohn's & Colitis, 2019
BACKGROUND AND AIMS In ulcerative colitis [UC], mucosal damage occurs in areas that are infiltrated with neutrophils. The antimicrobial function of neutrophils relies in part on the formation of extracellular web-like structures, named neutrophil ...
V. Dinallo, I. Marafini, D. Di Fusco, F. Laudisi, E. Franzè, A. Di Grazia, M. Figliuzzi, F. Caprioli, C. Stolfi, I. Monteleone, G. Monteleone   +10 more
semanticscholar   +1 more source