Results 111 to 120 of about 499,883 (421)

Neutrophil‐Mimicking Nanomedicine Eliminates Tumor Intracellular Bacteria and Enhances Chemotherapy on Liver Metastasis of Colorectal Cancer

Advanced Science, EarlyView.
Fusobacterium nucleatum (Fn) enrichment has been identified in colorectal cancer and its liver metastases. This study develops neutrophil‐mimicking nanoparticles with multiple targeting capabilities encapsulating metronidazole and oxaliplatin for antibacterial and anticancer purposes. This approach reverses the epithelial mesenchymal transition process
Yanan Niu, Xu Zhao, Yong Li, Xiaoya Ma, Weifeng Yang, Jie Ma, Wanglin Li, Wei Yuan   +7 more
wiley   +1 more source

The role of the Notch signalling pathway in the pathogenesis of ulcerative colitis: from the perspective of intestinal mucosal barrier

Frontiers in Medicine
Ulcerative colitis is a common digestive disorder worldwide, with increasing incidence in recent years. It is an urgent problem to be solved, as it seriously affects and threatens the health and life of the global population.
Hang Ning, Jiemin Liu, Jiaqian Tan, Mengni Yi, Xiaoyuan Lin   +4 more
doaj   +1 more source

Concomitant Guillain–Barré Syndrome in a young Sri Lankan male with severe ulcerative colitis

BMC Gastroenterology, 2022
Background Guillain–Barré Syndrome is an immune mediated polyneuropathy. Ulcerative Colitis is an immune mediated chronic inflammatory condition mainly of the large intestine. Guillain–Barré Syndrome can present as a rare extraintestinal manifestation of
Jayasundara Mudiyanselage Hishali Dahami Jayasundara, Vajira Tharanga Samarawickrama, Ranjith Peiris, Tilan Aponso, Danushi Abeynayake   +4 more
doaj   +1 more source

Mucosal adhesion and anti-inflammatory effects of Lactobacillus rhamnosus GG in the human colonic mucosa. A proof-of-concept study [PDF]

, 2018
AIM To investigate the adhesion and anti-inflammatory effects of Lactobacillus rhamnosus GG (LGG) in the colonic mucosa of healthy and ulcerative colitis (UC) patients, both in vivo and ex vivo in an organ culture model.
Corleto, Vito Domenico, D'Ambra, Giancarlo, Di Giulio, Emilio, Fave, Gianfranco Delle, Lanini, Claudio, Martorelli, Michela, Pagnini, Cristiano   +6 more
core   +1 more source

Microbial Biosensor for Sensing and Treatment of Intestinal Inflammation

Advanced Science, EarlyView.
The engineered calprotectin biosensor detects gut inflammation, processes the signal through genetic regulation, and responds by expressing the reporter sfGFP and the therapeutic protein secIL10. This dual functionality enables the engineered biosensor not only to sense but also to mitigate gut inflammation, highlighting its potential for disease ...
Duolong Zhu, Jeffrey Galley, Jason Pizzini, Elena Musteata, Martin V. Douglas, Walter J. Chazin, Eric P. Skaar, Jeffrey J. Tabor, Robert A. Britton   +8 more
wiley   +1 more source

Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 2: Current Management.

Journal of Crohn's & Colitis, 2017
aImperial College London, and Chelsea and Westminster Hospital, London, UK bDepartment of Gastroenterology and Hepatology, Chaim Sheba Medical Center, Tel Hashomer, Israel cDepartment of Medicine B, University Hospital Münster, Münster, Germany ...
M. Harbord, R. Eliakim, D. Bettenworth, K. Karmiris, K. Katsanos, U. Kopylov, T. Kucharzik, T. Molnár, T. Raine, S. Sebastian, Helena Tavares de Sousa, A. Dignass, F. Carbonnel   +12 more
semanticscholar   +1 more source

Non-Invasive monitoring of Inflammatory Bowel Disease : time to use newer tools? [PDF]

, 2013
Introduction: In inflammatory bowel disease (IBD), commonly used biomarkers employed for non-invasive monitoring of disease activity are the C-reactive Protein (CRP) and Erythrocyte Sedimentation Rate (ESR). Ulcerative colitis (UC) has a modest to absent
Azzopardi, Neville
core  

Reoperative pouch surgery for suspected Crohn's‐related complications aided by biologic coverage: Early experience from an inflammatory bowel disease center

Annals of Gastroenterological Surgery, EarlyView.
This paper demonstrates that revisional/redo ileal pouch anal anastomosis (IPAA) surgery with concurrent biologic therapy provides a viable, stoma‐free alternative for patients with Crohn's disease‐like complications, showing a high functioning pouch rate and expanding options for managing pouch failure.
Mehmet Gulmez, Daniel J. Wong, Ariela K. Holmer, Eren Esen, Shannon Chang, Arman Erkan, David Hudesman, Andre da Luz Moreira, Feza H. Remzi   +8 more
wiley   +1 more source

Building an AI Support Tool for Real-time Ulcerative Colitis Diagnosis [PDF]

Ulcerative Colitis (UC) is a chronic inflammatory bowel disease decreasing life quality through symptoms such as bloody diarrhoea and abdominal pain. Endoscopy is a cornerstone of diagnosis and monitoring of UC. The Mayo endoscopic subscore (MES) index is the standard for measuring UC severity during endoscopic evaluation.
arxiv   +1 more source

Medical management of inflammatory bowel disease [PDF]

, 1999
Patients who have recently been diagnosed as suffering from inflammatory bowel disease face two disturbing realities: firstly the true cause of the disease has not yet been defined and secondly the long term prognosis is unpredictable.
Pullicino, Edgar
core