Results 181 to 190 of about 269,130 (350)

Reshaping study design for faster extrapolation‐based drug approval in pediatric inflammatory bowel diseases: An ESPGHAN–NASPGHAN position paper

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Children with inflammatory bowel diseases (IBD) have limited access to the available advanced therapies, given the lengthy gap between adult and pediatric approval. We aimed to review key hurdles for pediatric trials and recommend practical solutions.
Dan Turner, Amit Assa, Mikkel Malham, Shira Yuval Bar‐Asher, Carla Rayan, Jeffrey S. Hyams, Holm H. Uhlig, Brad Pasternak, David C. Wilson, Hilary K. Michel, Lissy de Ridder, Eric Zuckerman, Marina Aloi, Peter Szitanyi, Marla C. Dubinsky, Anne M. Griffiths, Roberto Saldana, Javier Martín‐de‐Carpi, Eytan Wine, Richard K. Russell, Jeremy Adler, Joseph Picoraro   +21 more
wiley   +1 more source

Therapy de‐escalation in pediatric patients with inflammatory bowel disease in remission: Data analysis from the CEDATA registry

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives There are no standardized criteria about stepping down from combination therapy (immunomodulator and tumor necrosis factor (TNF)‐alpha‐inhibitors) in children with inflammatory bowel disease (IBD) to reduce risk for side effects. Our aim was to describe how de‐escalation has been performed in a large pediatric cohort and to find ...
Sila Cekin, Christoph Huenseler, Serdar Cantez, Ilse Broekaert, Jan de Laffolie, CEDATA‐GPGE® Study Group   +5 more
wiley   +1 more source

Ulcerative Colitis

International Journal of Clinical Practice, 1958
openaire   +3 more sources

Sulphasalazine in ulcerative colitis: in memoriam? [PDF]

, 1991
Jeremy Hayllar, Ingvar Bjarnason
openalex   +1 more source

Fatigue in pediatric inflammatory bowel disease: Explained by transdiagnostic and disease‐focused factors

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objective Fatigue is highly prevalent in children with inflammatory bowel disease (IBD), even during clinical remission. This suggests a role for transdiagnostic factors—lifestyle, psychological, and social influences not specific to the disease.
Maartje D. Stutvoet, Anouk Vroegindeweij, Tessa Z. Toonen, Merel M. Nap‐Van der Vlist, Johanna W. Hoefnagels, Anemone van den Berg, Sanne L. Nijhof   +6 more
wiley   +1 more source

GastroNet: A robust attention‐based deep learning and cosine similarity feature selection framework for gastrointestinal disease classification from endoscopic images

CAAI Transactions on Intelligence Technology, EarlyView., 2023
Abstract Diseases of the Gastrointestinal (GI) tract significantly affect the quality of human life and have a high fatality rate. Accurate diagnosis of GI diseases plays a pivotal role in healthcare systems. However, processing large amounts of medical image data can be challenging for radiologists and other medical professionals, increasing the risk ...
Muhammad Nouman Noor, Muhammad Nazir, Imran Ashraf, Nouf Abdullah Almujally, Muhammad Aslam, Syeda Fizzah Jilani   +5 more
wiley   +1 more source

Ulcerative colitis in Nigerian children: A report of two cases and review of the literature

Nigerian Journal of Paediatrics
: Ulcerative colitis (UC) is a relapsing, idiopathic chronic inflammatory disorder of colon characterised by ulcerations of the colon with bleeding, mucosal crypt abscesses and inflammatory pseudo polyps associated with abdominal pain with tenesmus and ...
Akinyinka OO, Adepoju AA , Ashubu OF, Ogunbosi BO, Olatunji RB, Akere A, Orimadegun AE, Oluwasola AO   +7 more
doaj  

Downregulation of Expression of Xenobiotic Efflux Genes is Associated with Pelvic Pouch Inflammation in Ulcerative Colitis [PDF]

, 2014
Boyko Kabakchiev, Andrea D. Tyler, Joanne M. Stempak, Raquel Milgrom, Mark S. Silverberg   +4 more
openalex   +1 more source

Adequate vitamin D is associated with favorable disease outcome in children with inflammatory bowel disease receiving anti‐tumor necrosis factor alpha therapy

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Deficiency of serum 25‐hydroxyvitamin D [25(OH)D] was associated with decreased short‐term response to anti‐tumor necrosis factor‐alpha (TNF‐α) agents in adults with inflammatory bowel disease (IBD). The aim of this study was to evaluate the association between serum 25(OH)D levels and the outcome of children with IBD undergoing ...
Adi Anafy, Yaara Manor, Maayan Shemer, Reut Doyev, Eytan Damari, Shlomi Cohen, Anat Yerushalmy‐Feler   +6 more
wiley   +1 more source

P336 Association between the prior duration of remission and efficacy outcomes in patients with Ulcerative Colitis treated with tofacitinib 10 mg twice daily who were in stable remission and either dose-reduced to tofacitinib 5 mg twice daily or remained on 10 mg twice daily: 6-month data from the double-blind, randomised RIVETING study [PDF]

, 2021
Marla C. Dubinsky, Geert D’Haens, William J. Sandborn, Siew C. Ng, Julián Panés, Chinyu Su, Nervin Lawendy, Irina Lazariciu, Sean Gardiner, Rajiv Mundayat, Nicole Kulisek, Irene Modesto, Joana Torres   +12 more
openalex   +1 more source