Results 31 to 40 of about 855,728 (251)

Low-background temperature sensors fabricated on parylene substrates

, 2015
Temperature sensors fabricated from ultra-low radioactivity materials have been developed for low-background experiments searching for neutrinoless double-beta decay and the interactions of WIMP dark matter.
Barton, P. J., Dhar, A., Larsen, J. T., Loach, J. C., Poon, A. W. P.   +4 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Quantization of the elastic modes in an isotropic plate

, 2006
We quantize the elastic modes in a plate. For this, we find a complete, orthogonal set of eigenfunctions of the elastic equations and we normalize them.
Anghel D V, Auld B A, D V Anghel, Kühn T Anghel D V Galperin Y M, Leivo M, Luukanen A, Riesz F, T Kühn   +7 more
core   +1 more source

Single Crystal Sapphire at milli-Kelvin Temperatures: Observation of Electromagnetically Induced Thermal Bistability in High Q-factor Whispering Gallery Modes [PDF]

, 2010
Resonance modes in single crystal sapphire ($\alpha$-Al$_2$O$_3$) exhibit extremely high electrical and mechanical Q-factors ($\approx 10^9$ at 4K), which are important characteristics for electromechanical experiments at the quantum limit. We report the
Creedon, Daniel L., Duty, Timothy, Floch, Jean-Michel Le, Reshitnyk, Yarema, Tobar, Michael E.   +4 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Superconducting noise-source for ultra-low temperatures

Technical Physics Letters, 2022
The device operates at temperatures <300 mK and comprises a hafnium microbridge and a superconducting aluminum tunnel junction both integrated into a common coplanar waveguide. The microbridge matches with a planar antenna and operates as an optical blackbody at frequencies 600-700 GHz.
null Shitov S. V., null Kim T. M.
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Temperature coefficients of crystalline-quartz elastic constants over the cryogenic range [4 K, 15 K]

, 2016
This paper brings out results of a measurement campaign aiming to determine the temperature coefficients of synthetic quartz elastic constants at liquid helium temperature.
Bon, Jérémy, Bourquin, Roger, Galliou, Serge   +2 more
core   +3 more sources

Ultra low noise YBCO nanoSQUIDs implementing nanowires [PDF]

, 2014
We present results on ultra low noise YBa$_2$Cu$_3$O$_{7-\delta}$ nano Superconducting QUantum Interference Devices (nanoSQUIDs). To realize such devices, we implemented high quality YBCO nanowires, working as weak links between two electrodes.
Arpaia, Riccardo, Arzeo, Marco, Bauch, Thilo, Charpentier, Sophie, Lombardi, Floriana, Nawaz, Shahid   +5 more
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source