Results 111 to 120 of about 11,409,916 (219)

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Storage of Euschistus heros (Fabricius, 1794) Eggs for Biological Control with Telenomus podisi Ashmead, 1851 in Open Fields in Brazil. [PDF]

Neotrop Entomol
Barreto MTS, Camarozano CT, de Melo MC, Junior AC, Gontijo LM, Takahashi TA, Parra JRP.   +6 more
europepmc   +1 more source

Friend, Not Foe: Lowered Tissue Reactivity to Long‐Term Polyimide Implants

Advanced Science, EarlyView.
The choice of optimal neural probe designs remains a major challenge in the field of neurotechnology. This study investigated the biocompatibility of several probe variations, including material, thickness, width, and implantation strategy. It highlights the clear advantage of soft polyimide probes over stiff silicon probes for better device ...
Corinne Orlemann, Laura M. De Santis, Paul Neering, Christian Boehler, Kirti Sharma, Arno Aarts, Tobias Holzhammer, Rik J. J. van Daal, Patrick Ruther, Maria Asplund, Roxana N. Kooijmans, Pieter R. Roelfsema   +11 more
wiley   +1 more source

A practical starting guide to tear fluid biobanking. [PDF]

Adv Ophthalmol Pract Res
Schmeetz J, Hagan S, van de Sande N, Boychev N, Kessal K, Tear Research Network Biobanking Taskforce, Gijs M.   +6 more
europepmc   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Vaccine cold chain and understanding what underpins vaccine security for vaccine preventable diseases. [PDF]

BMJ Med
Rukundo G, Moore M, Semukunzi H, Chatterjee S, Musabyimana JP, Mambo Muvunyi C, Green CA.   +6 more
europepmc   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Frozen storage of mAbs at elevated temperatures: Balancing stability and sustainability. [PDF]

Int J Pharm X
Nagel R, Baumeister N, Hauptmann A, Tober R, Bechtold-Peters K, Friess W.   +5 more
europepmc   +1 more source

Neuromorphic Near‐Sensor and In‐Sensor Computing Enabled by Next‐Generation Material‐Based Sensors

Advanced Science, EarlyView.
This Review presents a structural framework that classifies neuromorphic sensing into near‐sensor and in‐sensor architectures, clarifying physical coupling between sensing and computation. The framework connects neural and synaptic device functions with recent advances in optical, mechanical, and chemical sensing, compares energy consumption and ...
Su Yeon Jung, Gwang Ya Kim, Sejin Kim, Hyunjong Seo, Se Gi Lee, Sang Min Won, Dongjoon Rhee, Joohoon Kang   +7 more
wiley   +1 more source

Harmonizing biofluid specimen collection and biomarker quantification in Diverse Vascular Contributions to Cognitive Impairment and Dementia (DVCID) study. [PDF]

Alzheimers Dement (Amst)
Zhou S, Conston J, Suthprasertporn N, Denis-Romero R, Lucente JD, White JL, Mielke MM, Harvey D, Rajan KB, Johnson DK, Fornage M, DeCarli C, Hinman JD, Jin LW, DVCID Study Investigators.   +14 more
europepmc   +1 more source