Results 91 to 100 of about 166,094 (382)

Isolation and Characterization of a Cellular Protein-Lipid Complex from Ascites Fluid Caused by Various Neoplasms [PDF]

, 1986
High concentrations of lipids in ascites fluid caused by peritoneal carcinomatosis have been described recently. Since their nature has not yet been clarified, we isolated ascitic lipids from 25 patients with various neoplasms for further ...
Caselmann, Wolfgang H., Jüngst, Dieter
core  

Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules [PDF]

, 2018
Background: Microenvironment cues involved in melanoma progression are largely unknown. Melanoma is highly influenced in its aggressive phenotype by the changes it determinates in its microenvironment, such as pH decrease, in turn influencing cancer cell
A Albini, A Lardner, Alessandra Carè, AR Hess, Bok Hong, C Coscia, Carla Raggi, CC Jiang, CP Lai, Cristiana Zanetti, D Hanahan, E Alegre, E Willms, EK Rofstad, Elin J Ekström, Elisabetta Pizzi, Fabrizio Mattei, Federica Felicetti, Federica Fratini, G Helmlinger, G Raposo, H Mizuno, H Peinado, I Lazar, I Parolini, IF Robey, Isabella Parolini, J Kowal, J Lotvall, J Niu, J Skog, J Webber, Jessica Lamberti, JL Hood, JL Hood, JL Wike-Hooley, JM Graham, JR Knutson, K Al-Nedawi, Katia Fecchi, Luca Fantozzi, Luca Pasquini, M Colombo, M Logozzi, Massimo Sanchez, Massimo Sargiacomo, MR Muhsin-Sharafaldine, N Raghunand, O WARBURG, P Vaupel, R Valenti, RE Moellering, Rossella Puglisi, S Dror, S Dutta, S Peppicelli, SK Huang, Stefania D’Atri, T Fiaschi, T Fukamachi, T Groot Kormelink, T Kobayashi, V Estrella, V Pospichalova, V Vukovic, XY Yam, Y Ishihama, Zaira Boussadia   +67 more
core   +10 more sources

Balancing yield, purity and practicality: a modified differential ultracentrifugation protocol for efficient isolation of small extracellular vesicles from human serum

RNA Biology, 2019
Ultracentrifugation remains the gold standard for isolation of small extracellular vesicles (sEV), particularly for cancer applications. The objective of this study was to determine if a widely used ultracentrifugation protocol for isolation of serum sEV
Scott M Langevin, Damaris Kuhnell, M. Orr-Asman, J. Biesiada, Xiang Zhang, M. Medvedovic, H. Thomas   +6 more
semanticscholar   +1 more source

CLDN18.2 CAR‐derived Extracellular Vesicle Immunotherapy Improves Outcome in Murine Pancreatic Cancer

Advanced Healthcare Materials, EarlyView.
CLDN18.2 CAR‐T cell‐derived small extracellular vesicles (CAR‐sEVs) display potent cytotoxicity and prolong survival in preclinical pancreatic cancer models. They contain functional CAR proteins and granzyme B, exhibit antigen specificity, and effectively target tumor cells while sparing healthy cells.
Yue Qing, Ke Jiang, Hua Jiang, Yaru Zhao, Chu‐Hu Lai, Alexandra Aicher, Zonghai Li, Christopher Heeschen   +7 more
wiley   +1 more source

Lipoprotein separation in a novel iodixanol density gradient, for composition, density, and phenotype analysis

Journal of Lipid Research, 2008
Separation of lipoproteins by traditional sequential salt density floatation is a prolonged process (∼72 h) with variable recovery, whereas iodixanol-based, self-generating density gradients provide a rapid (∼4 h) alternative.
Michael S. Yee, Darrell V. Pavitt, Tira Tan, Soundararajan Venkatesan, Ian F. Godsland, William Richmond, Desmond G. Johnston   +6 more
doaj  

Effect of Nanoparticle Rigidity on the Interaction of Stromal Membrane Particles with Leukemia Cells

Advanced Healthcare Materials, EarlyView.
Cell membrane nanoparticles made with stromal cells are prepared and used to target leukemia cells. Deposition of the cell membrane onto rigid silica cores leads to increased uptake both in leukemia cell lines and primary cells from patients. These results show that nanoparticle rigidity affects the interaction between cell membrane nanoparticles and ...
Sander de Weerd, Xinyu Ma, Zahra Zohali, Lieve L. Oudejans, Emmanouil Kyrloglou, Marc. C. A. Stuart, Wouter H. Roos, Jan Jacob Schuringa, Anna Salvati   +8 more
wiley   +1 more source

Exosome-mediated transfer of miR-222 is sufficient to increase tumor malignancy in melanoma [PDF]

, 2016
BACKGROUND: Growing evidence is showing that metastatic cell populations are able to transfer their characteristics to less malignant cells. Exosomes (EXOs) are membrane vesicles of endocytic origin able to convey their cargo of mRNAs, microRNAs (miRs),
Bellenghi, Maria, Carè, Alessandra, Coscia, Carolina, Errico, Maria Cristina, Felicetti, Federica, Feo, Alessandra De, Pagani, Elena, Pasquini, Luca, Pedini, Francesca, Puglisi, Rossella   +9 more
core   +5 more sources

Albumin Corona Overturns Long‐Acting Behaviors of Myristic Acid‐Conjugated Quetiapine Nanosuspension

Advanced Healthcare Materials, EarlyView.
Albumin corona alters surface properties and enhances colloidal stability by overturning pH responsiveness and nano‐aggregation behaviors of long‐acting myristic acid‐conjugated quetiapine nanosuspensions (QMN), resulting in accelerated in vitro and in vivo drug release.
Hy Dinh Nguyen, Hai Van Ngo, Beom‐Jin Lee   +2 more
wiley   +1 more source

Multifunctional Neural Probes Enable Bidirectional Electrical, Optical, and Chemical Recording and Stimulation In Vivo

Advanced Materials, EarlyView.
Convergence drawing is used to create flexible, microscale, multifunctional fiber‐based neural probes. Optimized materials selection enables individual devices to perform neural recording, electrical stimulation, optogenetics, fiber photometry, fluid delivery, and voltammetric neurotransmitter detection in rodents.
Nicolette Driscoll, Marc‐Joseph Antonini, Taylor M. Cannon, Pema Maretich, Greatness Olaitan, Valerie Doan Phi Van, Keisuke Nagao, Atharva Sahasrabudhe, Emmanuel Vargas Paniagua, Ethan J. Frey, Ye Ji Kim, Sydney Hunt, Melissa Hummel, Sanju Mupparaju, Alan Jasanoff, B. Jill Venton, Polina Anikeeva   +16 more
wiley   +1 more source

Spectrum of polysaccharides degradation products of ales and lager beers [PDF]

, 2005
The saccharide spectrum, as a distribution of fractions of different molecular mass, of sixteen beers was determined by ultracentrifugation using filters with cut-offs of 1, 5, 10 and 50 kDa. The saccharide concentrations in the filtrates were determined
Claeyssens, Marc, Stals, Ingeborg, Van Landschoot, Anita, Vanderputten, Dana   +3 more
core   +1 more source