Results 131 to 140 of about 226,162 (380)

CRISPR in MOF Formulation with Enhanced Stability, Activity, and Altered PAM Specificity for Broad‐Spectrum Diagnosis of Bacterial Sepsis

open access: yesAdvanced Science, EarlyView.
CRISPR‐FLEXMO (CRISPR with flexible PAM in MOF encapsulation) integrates a PAM‐relaxed Cas12a K607R enzyme with a manganese‐coordinated MOF for broad‐spectrum diagnosis of bacterial sepsis. The MOF enhances activity and preserves functionality under heat, solvent, and chaotropic stress, supporting long‐term room‐temperature storage.
Tathagata Pal   +3 more
wiley   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

open access: yesAdvanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei   +10 more
wiley   +1 more source

Effect of pH of Coagulant on the Treatment of Wastewater from Tofu Industry

open access: yesE3S Web of Conferences, 2018
Wastewater generated from the tofu industry usually still contains high organic pollutants that can contaminate the surface water. Therefore, it should be treated properly before it can be disposed to the environment.
Aditya Irfan, Kartohardjono Sutrasno
doaj   +1 more source

Influence of Type of Substrate and Enzyme Concentration on Formation of Galacto-oligosaccharides

open access: yesCzech Journal of Food Sciences, 2009
Different substrates and different concentrations of enzyme (Maxilact LX 5000) for galacto-oligosaccharides synthesis were tested. Lactose in phosphate buffer (138 mmol/l), ultrafiltration permeate (115 mmol/l), recombined whey (136 mmol/l) were used as ...
K. Hellerová, L. Čurda
doaj   +1 more source

Antioxidant and antihypertensive activities of rice bran peptides [PDF]

open access: yes, 2011
Protein isolates and peptide fractions from food sources (cereal grains), have been shown to exert bioactive properties including antiobesity, anticancer, antiangiogenic, etc.
Hettiarachchy, Navam S.   +2 more
core   +2 more sources

Treatment of stabilized landfill leachate in an integrated adsorption–fine-ultrafiltration system

open access: yesInternational Journal of Environmental Science and Technology, 2018
This study investigated the feasibility of using an adsorption–fine-ultrafiltration system for removing organics from stabilized landfill leachate. For adsorption, Norit SX2 powdered activated carbon was used; the fine-ultrafiltration system was equipped
D. Kulikowska, M. Zielińska, K. Konopka
semanticscholar   +1 more source

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao   +13 more
wiley   +1 more source

Novel use of an ultrafiltration device as an alternative method for fluid removal in critically ill pediatric patients with cardiac disease: a case series

open access: yesPediatric Reports, 2016
Fluid overload (FO) is a common complication for pediatric patients in the intensive care unit. When conventional therapy fails, hemodialysis or peritoneal dialysis is classically used for fluid removal.
Sujata Chakravarti   +5 more
doaj   +1 more source

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