Results 41 to 50 of about 85,498 (248)

Mechanism‐Driven Nanoformulations for Cognitive Impairment Induced by Intermittent Hypoxia and Periodontitis

Advanced Materials, EarlyView.
Clinically, intermittent hypoxia (IH) is often accompanied by periodontitis, which accelerates cognitive impairment induced by IH. Novel Janus mesoporous gold‐silica nanoformulations (RVG‐Au&mSiO2‐TPP‐VB) enable intranasal delivery, achieve hierarchical targeting to neuronal mitochondria, effectively scavenge reactive oxygen species, inhibit the HIF‐1α/
Kai‐Run Zhang, Tianbao Zhu, An‐Qi Liu, Jia‐Jia Deng, Ya‐Li Han, Sheng‐Cai Qi, Xue Liu, Tian‐Yi Jiang, Ming‐Rui Zhai, Yu‐Ying He, Xiu‐Juan Li, Hong‐Ting Da, Rui Xu, Xiaomin Li, Jun Gao, Yue‐Hua Liu   +15 more
wiley   +1 more source

Three in one: evolution of viviparity, coenocytic placenta and polyembryony in cyclostome bryozoans

BMC Ecology and Evolution, 2021
Background Placentation has evolved multiple times among both chordates and invertebrates. Although they are structurally less complex, invertebrate placentae are much more diverse in their origin, development and position.
U. A. Nekliudova, T. F. Schwaha, O. N. Kotenko, D. Gruber, N. Cyran, A. N. Ostrovsky   +5 more
doaj   +1 more source

The Effect of the Synergistic Combination of Vitamin D and Doxorubicin on the MCF-7 Line Breast Cancer Cells

Biology and Life Sciences Forum, 2023
Breast cancer is the most prevalent cancer in the female population. The prolonged action of estrogen may affect tumor proliferation. Additionally, a fat-rich diet may have various effects on cancer proliferation, depending on the type of fat. Vitamin D,
Kamila Sobczak, Agnieszka Mlicka, Paweł Niewiadomski, Oliwia Abramczyk, Wioletta Zielińska, Marta Hałas-Wiśniewska, Magdalena Izdebska   +6 more
doaj   +1 more source

Ultrastructure of a craniopharyngioma [PDF]

Cancer, 1971
A craniopharyngioma removed at surgery was examined by light and electron microscopy. The tumor consisted of both solid and cystic components. The cells lining the cysts, as well as those forming the solid masses, displayed desmosomes, tonofilaments, keratohyalin granules, and keratinization identical to those seen in the epidermis.
N R, Ghatak, A, Hirano, H M, Zimmerman
openaire   +2 more sources

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Impact of 2D versus 3D fibroblast models on Leishmania species invasion in vitro: Rab5 dynamics and actin activity in initial infection

Frontiers in Cellular and Infection Microbiology
BackgroundThe protozoan Leishmania, in addition to infecting phagocytic cells such as macrophages, can also invade non-professional phagocytic cells like fibroblasts, a process previously described in 2D models.
Rebecca Thereza Silva Santa Brígida, Rebecca Thereza Silva Santa Brígida, Adeniele Lopes da Cruz Carneiro, Adeniele Lopes da Cruz Carneiro, Felipe Tuji de Castro Franco, Brenda Furtado Costa, Brenda Furtado Costa, Ana Paula Drummond Rodrigues   +7 more
doaj   +1 more source

The better to eat you with: morphological disparity and enamel ultrastructure in odontocetes

Scientific Reports, 2023
Variations in the shape and size of teeth have been associated with changes in enamel ultrastructure across odontocetes. Characterizing these features in extinct taxa can elucidate their functional morphology and feeding strategy, while also shedding ...
Mariana Viglino, Martín D. Ezcurra, R. Ewan Fordyce, Carolina Loch   +3 more
doaj   +1 more source

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Dopa-stained melanocytes in the macular lesions of early leprosy

Hansenologia Internationalis, 1996
The mechanism of association of hypopigmentation and sensorial loss in a leprosy macular lesions has not been clarified yet. The biopsy of a macular lesion on the medial face of the right forearm of a fourteen-year old male leprosy patient was submitted
Sérgio Luiz Gomes Antunes, Samantha Lee Salgueiro Alves, Suzana Corte-Real, Maria Nazaré Meireles, José Augusto da Costa Nery, Euzenir Nunes Sarno   +5 more
doaj   +1 more source