Results 171 to 180 of about 115,466 (314)

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

The 3D Ultrastructure of <i>C. elegans</i> Gut Granules. [PDF]

MicroPubl Biol
Archer G, Bartlowe S, Bayarbadrakh B, Bok D, Bushong C, Carroll A, Cole M, Dahl Ii EJ, Denier N, Elewa A, El Harchi H, Fisher D, Grant H, Grijalva A, Grinfeld R, Hale A, Hendricks C, Iskandar M, Kagan S, Keuneke H, Lammers L, Lyons A, Maclin Q, Mistry N, Moore T, Munro C, Nickerson G, Papalia B, Peacock K, Ritzman L, Ross A, Samineni R, Scales M, Schotz L, Sikkema W, Slabaugh T, Sorenson A, Sutherland S, Swisher R, Valdes D, Ward F, Wojdyla P.   +41 more
europepmc   +1 more source

Valproic Acid Inhibits Ferroptosis and Improves Bone Integration in OVX Rats Through the AMPK/SIRT1 Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The prevalence of postmenopausal osteoporosis (PMOP) has been steadily increasing. Ferroptosis has been recognized as a critical factor influencing the bone‐forming ability of bone marrow mesenchymal stem cells (BMSCs). Valproic acid (VPA), an HDAC inhibitor, has been suggested to play a role in regulating osteoporosis development; however ...
Qing‐Song Gu, Yi‐Fan Gu, Jian‐Qiao Li, Yi‐Heng Li, Yu‐Hu Chen, Lin‐Hui Wang, Zi‐Ru Wang, Yi‐Cong Wang, Min Yang   +8 more
wiley   +1 more source

Age-related differences in asymmetric synapses across the central inferior colliculus in the Fischer Brown Norway rat. [PDF]

Aging Brain
Barach GL, Wawrzyniak A, Busby J, Duncan S, Almassri LS, Mafi A, Tokar NJ, Silveira MA, Young JW, Mellott JG.   +9 more
europepmc   +1 more source

The Regulatory Role and Mechanism of Myoferlin in Mitophagy During Papillary Thyroid Carcinogenesis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Papillary thyroid carcinoma (PTC) is the most prevalent subtype of thyroid cancer; however, the regulatory mechanisms by which mitophagy influences its progression remain inadequately elucidated. This study sought to examine the role of myoferlin (MYOF) in mitophagy and its molecular basis during PTC development. Utilizing three paired PTC and
Wen‐Chao Lyu, Yang‐Shuai Wang, Chun‐Yang Shang, Ming Qi, Tong‐Chang Li, Li‐Xin Lian, Hai‐Quan Qiao   +6 more
wiley   +1 more source

Ultrastructure, Polarity, and Reproduction of the Golgi Apparatus. [PDF]

Biol Cell
Goud B.
europepmc   +1 more source

Review of Congenital Myasthenic Syndrome Caused by Pathogenic Variants in GFPT1

Muscle &Nerve, EarlyView.
ABSTRACT Glutamine:fructose‐6‐phosphate transaminase 1 (GFPT1) catalyzes the first and rate‐limiting step of the hexosamine biosynthetic pathway (HBP) to generate UDP‐GlcNAc. GFPT1 exon 9 is specifically spliced in in striated muscles, which makes a long isoform of GFPT1 (GFPT1‐L).
Kinji Ohno, Mohammad Nazim, Ruchen Zhang, Paniz Farshadyeganeh, Mikako Ito, Bisei Ohkawara   +5 more
wiley   +1 more source

Transmission Electron Microscopy Corneal Ultrastructure Study in Hematocornea of Corneal Transplant Graft. [PDF]

Diagnostics (Basel)
Curcă PF, Macovei L, Mușat O, Zemba M, Dinu V, Gherghiceanu M, Tătaru CI, Tătaru CP.   +7 more
europepmc   +1 more source

Safety, efficacy, pharmacokinetics, and mechanisms of novel 10B‐boronophenylalanine combined with a radio‐frequency quadrupole accelerator in boron neutron capture therapy: A preclinical study in head and neck squamous cell carcinoma

Precision Radiation Oncology, EarlyView.
This study demonstrates that the novel 10B‐BPA‐based BNCT system, combined with an RFQ accelerator, effectively targets head and neck squamous cell carcinoma. It induces tumor regression safely and efficiently by triggering DNA damage and activating the ROS/HIF‐1α/NF‐κB pathway, leading to caspase‐3‐mediated apoptosis.
Zhaoyuan Zhang, Junyan Li, Minhua Fan, Huafu Ouyang, Qiubo Chu, Huijie Yan, Yannan Zheng, Linxuan Huang, Gui Bao, Zhenting Ma, Shaobo Huang, Lin Li, Xiao Xu, Zhigang Liu   +13 more
wiley   +1 more source

The Value of Nasal Nitric Oxide Measurement in the Diagnosis of Primary Ciliary Dyskinesia. [PDF]

Pediatr Pulmonol
Haarman EG, Israëls J, Rutjes NW, Paff T.   +3 more
europepmc   +1 more source