Results 161 to 170 of about 85,498 (248)

The Regulatory Role and Mechanism of Myoferlin in Mitophagy During Papillary Thyroid Carcinogenesis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Papillary thyroid carcinoma (PTC) is the most prevalent subtype of thyroid cancer; however, the regulatory mechanisms by which mitophagy influences its progression remain inadequately elucidated. This study sought to examine the role of myoferlin (MYOF) in mitophagy and its molecular basis during PTC development. Utilizing three paired PTC and
Wen‐Chao Lyu, Yang‐Shuai Wang, Chun‐Yang Shang, Ming Qi, Tong‐Chang Li, Li‐Xin Lian, Hai‐Quan Qiao   +6 more
wiley   +1 more source

Integrative taxonomic study reveals a new species of Maculolachnus (Hemiptera: Aphididae) from South Korea. [PDF]

Sci Rep
Lee M, Kanturski M, Lee S.
europepmc   +1 more source

Review of Congenital Myasthenic Syndrome Caused by Pathogenic Variants in GFPT1

Muscle &Nerve, EarlyView.
ABSTRACT Glutamine:fructose‐6‐phosphate transaminase 1 (GFPT1) catalyzes the first and rate‐limiting step of the hexosamine biosynthetic pathway (HBP) to generate UDP‐GlcNAc. GFPT1 exon 9 is specifically spliced in in striated muscles, which makes a long isoform of GFPT1 (GFPT1‐L).
Kinji Ohno, Mohammad Nazim, Ruchen Zhang, Paniz Farshadyeganeh, Mikako Ito, Bisei Ohkawara   +5 more
wiley   +1 more source

Ultrastructural analysis of human uncinate fasciculus with coherent anti-Stokes Raman spectroscopy. [PDF]

Biophotonics Discov
Perlman K, Noël VP, Collin A, Major J, Mardenli M, Jerczynski S, Davoli MA, Cohen-Adad J, Côté D, Mechawar N.   +9 more
europepmc   +1 more source

Safety, efficacy, pharmacokinetics, and mechanisms of novel 10B‐boronophenylalanine combined with a radio‐frequency quadrupole accelerator in boron neutron capture therapy: A preclinical study in head and neck squamous cell carcinoma

Precision Radiation Oncology, EarlyView.
This study demonstrates that the novel 10B‐BPA‐based BNCT system, combined with an RFQ accelerator, effectively targets head and neck squamous cell carcinoma. It induces tumor regression safely and efficiently by triggering DNA damage and activating the ROS/HIF‐1α/NF‐κB pathway, leading to caspase‐3‐mediated apoptosis.
Zhaoyuan Zhang, Junyan Li, Minhua Fan, Huafu Ouyang, Qiubo Chu, Huijie Yan, Yannan Zheng, Linxuan Huang, Gui Bao, Zhenting Ma, Shaobo Huang, Lin Li, Xiao Xu, Zhigang Liu   +13 more
wiley   +1 more source

Alpha-cell glucagon is essential for maintaining β-cell function and identity in adult mice. [PDF]

J Biol Chem
Prasadan K, Saleh M, Thomas M, Al Abyad O, Shiota C, Molitoris J, Zhang T, Sehrawat A, Tariq M, Rajasundaram D, King S, Kalsi R, Xiao X, Piganelli J, Esni F, Gittes GK.   +15 more
europepmc   +1 more source

BODIPY Photocage‐Based Injectable Hydrogel for Light‐Controlled Nanoparticle Release

Small, EarlyView.
This work presents an injectable hydrogel formulation which undergoes efficient photodegradation under green light irradiation. The gel can be easily injected to subcutaneous tissue through 23G needles, co‐encapsulate and photo‐release nanoparticles as well as exhibits excellent biocompatibility, making it promising for the development of light ...
Baihao Shao, David J. Peeler, Thomas F. F. Fernandez Debets, Jonathan P. Wojciechowski, Yue Shao, Yuxi Cheng, Kun Zhou, Robin J. Shattock, Molly M. Stevens   +8 more
wiley   +1 more source

Clofazimine against cerebral toxoplasmosis in diabetic and dexamethasone-immunosuppressed mice: ultrastructural and semiquantitative transmission electron microscopic study. [PDF]

BMC Neurosci
Fahmy MA, Abdel-Aal AA, Hassan SI, Shalaby MA, Esmat M.   +4 more
europepmc   +1 more source

Rotenone Induces Morphological Damage and Reduction in Catecholamine Levels in the Central Nervous System of the Ascidian Styela plicata

Environmental Toxicology, EarlyView.
ABSTRACT Ascidians are invertebrates that occupy a key phylogenetic position as a sister group of the vertebrates. The organization of their central nervous system (CNS), with cortex and medulla, indicates a plesiomorphic character of the gray and white matter of vertebrates, making this group of animals useful for studies of neurodegenerative events ...
Andressa de Abreu Mello, Carlos Augusto Borges de Andrade Gomes, Rafaela Rocha dos Santos, Cintia Monteiro de Barros, Silvana Allodi   +4 more
wiley   +1 more source