Results 191 to 200 of about 91,371 (267)

The role of tryptophan hydroxylase‐1 in metabolic dysfunction‐associated steatotic liver disease

Pediatric Investigation, EarlyView.
Silencing hepatic tryptophan hydroxylase 1 (TPH1) alleviated diet‐induced steatotic liver disease by reducing lipid accumulation, oxidative stress, inflammation, fibrosis, and hepatocyte apoptosis. These protective effects were mediated, at least in part, through restoration of Parkin‐dependent mitochondrial autophagy, identifying hepatic TPH1 as a ...
Shuangzhen Jia, Xiaolin Ye, Zhaoxia Wang, Jie Wu   +3 more
wiley   +1 more source

Hafnium-Substituted Wells-Dawson Polyoxometalate as a High-Performance Contrast Agent for Transmission Electron Microscopy of Biological Ultrastructure. [PDF]

Int J Mol Sci
Milosavljević A, Ćetković M, Kravić-Stevović T, Stojanović M, Čolović MB, Savić ND, Parac-Vogt TN, Krstić D.   +7 more
europepmc   +1 more source

Safety, efficacy, pharmacokinetics, and mechanisms of novel 10B‐boronophenylalanine combined with a radio‐frequency quadrupole accelerator in boron neutron capture therapy: A preclinical study in head and neck squamous cell carcinoma

Precision Radiation Oncology, EarlyView.
This study demonstrates that the novel 10B‐BPA‐based BNCT system, combined with an RFQ accelerator, effectively targets head and neck squamous cell carcinoma. It induces tumor regression safely and efficiently by triggering DNA damage and activating the ROS/HIF‐1α/NF‐κB pathway, leading to caspase‐3‐mediated apoptosis.
Zhaoyuan Zhang, Junyan Li, Minhua Fan, Huafu Ouyang, Qiubo Chu, Huijie Yan, Yannan Zheng, Linxuan Huang, Gui Bao, Zhenting Ma, Shaobo Huang, Lin Li, Xiao Xu, Zhigang Liu   +13 more
wiley   +1 more source

Accomplishments of "Old-Fashioned" Electron Microscopy in the Period of Dominance of Immunofluorescent Methods. [PDF]

Int J Mol Sci
Morozov YM, Rakic P.
europepmc   +1 more source

Navigating Classical and Nonclassical Realms of Nucleation and Crystallization

Small, EarlyView.
Classical nucleation and growth theories have long been foundational, yet recent nonclassical concepts have challenged and refined our understanding of solid‐state genesis. This paradigm shift introduced new, often ambiguous vocabulary. Here, we clarify key concepts, correct common misconceptions, and provide a terminological field guide across systems,
Stephan E. Wolf, Peter G. Vekilov
wiley   +1 more source

Disruption of Fructose 1,6-Bisphosphatase 2 Proximity to MIC60 Correlates with Mitochondrial Ultrastructural Changes. [PDF]

Cells
Pietras Ł, Migocka-Patrzałek M, Budziak B, Rakus D, Gizak A.   +4 more
europepmc   +1 more source

Rotenone Induces Morphological Damage and Reduction in Catecholamine Levels in the Central Nervous System of the Ascidian Styela plicata

Environmental Toxicology, EarlyView.
ABSTRACT Ascidians are invertebrates that occupy a key phylogenetic position as a sister group of the vertebrates. The organization of their central nervous system (CNS), with cortex and medulla, indicates a plesiomorphic character of the gray and white matter of vertebrates, making this group of animals useful for studies of neurodegenerative events ...
Andressa de Abreu Mello, Carlos Augusto Borges de Andrade Gomes, Rafaela Rocha dos Santos, Cintia Monteiro de Barros, Silvana Allodi   +4 more
wiley   +1 more source

Correction: TRPV1 deletion in male mice alters cardiomyocyte ultrastructure without affecting baseline cardiac function. [PDF]

Sci Rep
Tessier N, Païta L, Chouabe C, Thibault H, Melka M, Ducrozet M, Al-Mawla R, Harisseh R, Léon C, Augeul L, Dupré-Aucouturier S, Bidaux G, Ovize M, Van Coppenolle F, Ducreux S.   +14 more
europepmc   +1 more source

Nonthermal plasma approaches for combating implant‐associated infections: A compendious review

VIEW, EarlyView.
Implant‐associated infections pose serious clinical challenges. Non‐thermal plasma (NTP) modifications overcome this bottleneck in distinct ways relative to traditional sterilization methods. Gas‐phase plasmas generate highly energetic species, UV radiation and reactive oxygen/nitrogen species (RONS), which alter the implant surface properties.
A. M. Trimukhe, Satish Rojekar, Amol Gholap, K. Navaneetha Pandiyaraj, Mukesh Patekar, Claudia Riccardi, R. R. Deshmukh, Tomáš Kovářík, Kalim Deshmukh   +8 more
wiley   +1 more source

Correction: Kim et al. Anti-Inflammatory Response and Muscarinic Cholinergic Regulation During the Laxative Effect of <i>Asparagus cochinchinensis</i> in Loperamide-Induced Constipation of SD Rats. <i>Int. J. Mol. Sci.</i> 2019, <i>20</i>, 946. [PDF]

Int J Mol Sci
Kim JE, Park JW, Kang MJ, Choi HJ, Bae SJ, Choi YS, Lee YJ, Lee HS, Hong JT, Hwang DY.   +9 more
europepmc   +1 more source