Results 51 to 60 of about 924,592 (305)

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Laser-stimulated fluorescence reveals unseen details in fossils from the Upper Jurassic Solnhofen Limestones

Royal Society Open Science, 2021
Laser-stimulated fluorescence (LSF) has seen increased use in palaeontological investigations in recent years. The method uses the high flux of laser light of visible wavelengths to reveal details sometimes missed by traditional long-wave ultraviolet (UV)
Luke A. Barlow, Michael Pittman, Anthony Butcher, David M. Martill, Thomas G. Kaye   +4 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

CONSIDERATIONS CONCERNING THE INFLUENCE OF UV RADIATIONS ON THE BODY [PDF]

Analele Universităţii "Constantin Brâncuşi" din Târgu Jiu: Seria Inginerie, 2019
This paper shows how the association between ultraviolet light (UV) and the diseases produced by the human body. There is strong evidence that exposure to ultraviolet radiation (UVR) is associated with malignancy of basal cell carcinoma, photokeratitis ...
Roxana Mecu, Daniela Cîrţînă, Valentin Nănescu   +2 more
doaj  

Ultraviolet interferometer [PDF]

, 1971
Grazing-incidence multi-beam interferometer /GIMBI/ obtains high resolution spectroscopic data from ultraviolet region of the spectrum without use of concave diffraction gratings or partially reflecting coatings.
Day, R. A.
core   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

The hydrogen Lyman α line shape in the exospheres of terrestrial objects in the solar system

Frontiers in Astronomy and Space Sciences
The exospheres of all objects are mostly made of atomic hydrogen. Because the Sun is bright in Lyman α, the properties of the H atoms in the exospheres of certain terrestrial solar system objects can be studied by analyzing the resonantly scattered solar
Dolon Bhattacharyya, Edward M. B. Thiemann, Janet Machol, Janet Machol, Gonzalo Cucho-Padin, Gonzalo Cucho-Padin, Sabyasachi Chatterjee, Walter Harris, Edwin Mierkiewicz   +8 more
doaj   +1 more source

The Ultraviolet Brightest Type Ia Supernova 2011de [PDF]

, 2014
We present and discuss the UV/optical photometric light curves and absolute magnitudes of the Type Ia supernova (SN) 2011de from the Swift Ultraviolet/Optical Telescope.
Brown, Peter J.
core   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source