Results 61 to 70 of about 531,876 (306)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Operation of a free-electron laser from the extreme ultraviolet to the water window [PDF]

open access: yes, 2007
We report results on the performance of a free-electron laser operating at a wavelength of 13.7 nm where unprecedented peak and average powers for a coherent extreme-ultraviolet radiation source have been measured.
T. Jezynski   +761 more
core   +2 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Laser-stimulated fluorescence reveals unseen details in fossils from the Upper Jurassic Solnhofen Limestones

open access: yesRoyal Society Open Science, 2021
Laser-stimulated fluorescence (LSF) has seen increased use in palaeontological investigations in recent years. The method uses the high flux of laser light of visible wavelengths to reveal details sometimes missed by traditional long-wave ultraviolet (UV)
Luke A. Barlow   +4 more
doaj   +1 more source

Upper-Room Ultraviolet Light and Negative Air Ionization to Prevent Tuberculosis Transmission [PDF]

open access: yes, 2009
Background Institutional tuberculosis (TB) transmission is an important public health problem highlighted by the HIV/AIDS pandemic and the emergence of multidrug- and extensively drug-resistant TB.
Ticona, E.   +70 more
core   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

CONSIDERATIONS CONCERNING THE INFLUENCE OF UV RADIATIONS ON THE BODY [PDF]

open access: yesAnalele Universităţii "Constantin Brâncuşi" din Târgu Jiu: Seria Inginerie, 2019
This paper shows how the association between ultraviolet light (UV) and the diseases produced by the human body. There is strong evidence that exposure to ultraviolet radiation (UVR) is associated with malignancy of basal cell carcinoma, photokeratitis ...
Roxana Mecu   +2 more
doaj  

Spectroscopic observation of planetary and moon exospheres in the ultraviolet

open access: yes, 2022
The PLanetary extreme Ultraviolet Spectrometer (PLUS) is a project funded by the Italian Space Agency focused on the development of an extreme (EUV) and far-ultraviolet (FUV) high-performance spectrograph, which adopts a dual channel optical scheme ...
Favaro, Giulio   +17 more
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

The hydrogen Lyman α line shape in the exospheres of terrestrial objects in the solar system

open access: yesFrontiers in Astronomy and Space Sciences
The exospheres of all objects are mostly made of atomic hydrogen. Because the Sun is bright in Lyman α, the properties of the H atoms in the exospheres of certain terrestrial solar system objects can be studied by analyzing the resonantly scattered solar
Dolon Bhattacharyya   +8 more
doaj   +1 more source

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