Results 221 to 230 of about 522,116 (371)

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

open access: yesBrain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña   +20 more
wiley   +1 more source

Relationship Between PTBP1 and Pancreatic Cancer Based on microRNA and Behavior During TYMS‐Mediated Carcinogenesis

open access: yesCancer Science, EarlyView.
Corresponding Author and colleagues identify a pancreas‐enriched microRNA, miR‐216b‐5p, that suppresses PTBP1 and its downstream effector TYMS. Their findings reveal a novel miR‐216b‐5p/PTBP1/TYMS regulatory axis driving pancreatic cancer progression and establish PTBP1 as a central molecular regulator of tumor biology beyond its metabolic role ...
Shigenori Suzuki   +14 more
wiley   +1 more source

Disentangling mechanisms that mediate soil fungal α and β diversity during forest secondary succession

open access: yesEcography, EarlyView.
Understanding the mechanisms controlling community diversity is a central, topic in ecology, particularly in microbial ecology. Although species pools and local assembly processes are believed to play non‐negligible roles in shaping the within‐community (α) and among‐community (β) diversity of microbial communities, their relative importance as ...
Xiao Zhang   +10 more
wiley   +1 more source

The effects of material thicknesses and substrates on the translucency and color masking ability of additively manufactured definitive crown materials

open access: yesJournal of Prosthodontics, EarlyView.
Abstract Purpose To investigate the translucency of the new 3D‐printable materials concerning thickness and the color masking ability of each material against different substrate colors. Materials and Methods Ninety square‐shaped specimens (12.0 mm × 12.0 mm) of two new 3D‐printable materials: ceramic‐infiltrated hybrid resin composite (VS) and light ...
Ting Wang   +5 more
wiley   +1 more source

Extrusion and Pancreatin Superdosing Modulate the Metabolic Impact of 20% Chlorella vulgaris Inclusion in Broiler Diets

open access: yesJournal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Microalgae such as Chlorella vulgaris are gaining attention as sustainable and nutritionally valuable feed ingredients, with the potential to partially replace soybean meal in broiler diets. However, dietary inclusion of 20% C. vulgaris has been attempted, but negatively affected growth performance due to limited digestibility.
Ana Rita Mendes   +12 more
wiley   +1 more source

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