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Anti-Melanogenic Effects of Umbelliferone: In Vitro and Clinical Studies
MoleculesMelanin overexpression causes skin hyperpigmentation, which is associated with various skin disorders and cosmetic concerns. Umbelliferone, a natural coumarin found widely in plant species, has been noted for its antioxidant and anti-inflammatory effects
Mi-Sun Kim, Da Jung Kim
exaly +4 more sources
Does umbelliferone protect primary cortical neuron cells against glutamate excitotoxicity [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2021 Glutamate is the major excitatory neurotransmitter in the central nervous system. Excessive glutamate is known to cause excitotoxicity. Umbelliferone is a coumarin derivative compound and has anti-oxidant, anti-infl ammatory, and neuroprotective eff ects.
Alper Kürşat DEMİRKAYA +5 more
doaj +3 more sources
Umbelliferone: Sources, chemistry and bioactivities review
Bulletin of Faculty of Pharmacy Cairo University, 2017 Umbelliferone is a 7-hydroxycoumarin that is a pharmacologically active agent. It is widely distributed within the Rutaceae and Apiaceae (Umbelliferae) families and is efficiently extracted using methanol.
Ofentse Mazimba
doaj +2 more sources
The Use of Umbelliferone in the Synthesis of New Heterocyclic Compounds
Molecules, 2011 New coumarin derivatives, namely 7-[(5-amino-1,3,4-thiadiazol-2-yl)methoxy]-2H-chromen-2-one (4), 5-[(2-oxo-2H-chromen-7-yloxy)methyl]-1,3,4-thiadiazol-2(3H)-one (5), 2-[2-(2-oxo-2H-chromen-7-yloxy)acetyl]-N-phenylhydrazinecarbothioamide (7), 7-[(5 ...
Abu Bakar Mohamad +2 more
exaly +3 more sources
Soil Effects on the Bioactivity of Hydroxycoumarins as Plant Allelochemicals
Plants, 2023 Soil plays a primary role in the activity of plant allelochemicals in natural and agricultural systems. In this work, we compared the phytotoxicity of three natural hydroxycoumarins (umbelliferone, esculetin, and scopoletin) to different model plant ...
Gracia Facenda +4 more
doaj +1 more source
Iraqi Journal of Pharmaceutical Sciences, 2021 The present investigation developed the ester prodrugs of Non-steroidal anti inflammatory drugs (NSAIDs), Mefenamic acid and Flurbiprofen by conjugating with the natural antioxidant, 4-methyl umbelliferone that resulted the formation of Mefenamic acid ...
NIJA B, Arun Rasheed, A Kottaimuthu
doaj +1 more source
Pharmaceuticals, 2023 Umbelliferone (UMB), known as 7-hydroxycoumarin, hydrangine, or skimmetine, is a naturally occurring coumarin in the plant kingdom, mainly from the Umbelliferae family that possesses a wide variety of pharmacological properties.
Anita Kornicka +3 more
doaj +1 more source
Renoprotective effect of umbelliferone in high-fat diet/streptozotocin-induced type 2 diabetic rats
Asian Pacific Journal of Tropical Biomedicine, 2020 Objective: To evaluate the renoprotective effect of umbelliferone in high-fat diet/streptozotocin-induced type 2 diabetic rats. Methods: We established a streptozotocin-induced type 2 diabetic model in male Wistar rats.
Jarinyaporn Naowaboot +2 more
doaj +1 more source
Challenges in the Heterologous Production of Furanocoumarins in Escherichia coli
Molecules, 2022 Coumarins and furanocoumarins are plant secondary metabolites with known biological activities. As they are present in low amounts in plants, their heterologous production emerged as a more sustainable and efficient approach to plant extraction. Although
Joana L. Rodrigues +2 more
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Frontiers in Cellular and Infection Microbiology, 2022 Pseudomonas aeruginosa easily adapts to newer environments and acquires several genome flexibilities to overcome the effect of antibiotics during therapeutics, especially in cystic fibrosis patients.
Thirupathi Kasthuri +3 more
doaj +1 more source