Umbelliferone preserves skin epidermal barrier integrity in diabetes-induced keratinocytes by regulating actin dynamics and suppressing ROS-mediated apoptosis [PDF]
Nutrition & DiabetesBackground The skin serves as a fundamental protective barrier against environmental insults, with the epidermis, particularly the stratum corneum and tight junctions (TJs) connecting keratinocytes, playing a crucial role.
Dong Yeon Kim +2 more
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Anti-Melanogenic Effects of Umbelliferone: In Vitro and Clinical Studies [PDF]
MoleculesMelanin overexpression causes skin hyperpigmentation, which is associated with various skin disorders and cosmetic concerns. Umbelliferone, a natural coumarin found widely in plant species, has been noted for its antioxidant and anti-inflammatory effects
Da Jung Kim +4 more
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Umbelliferone as an effective component of Rhodiola for protecting the cerebral microvascular endothelial barrier in cSVD [PDF]
Frontiers in PharmacologyObjectiveRhodiola is a common Chinese herb in the treatment of cerebral small vessel disease (cSVD). Umbelliferone, one of the effective components of Rhodiola, can protect the endothelial barrier. But its mechanisms are still unclear.
Li Tang +4 more
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The Use of Umbelliferone in the Synthesis of New Heterocyclic Compounds
Molecules, 2011 New coumarin derivatives, namely 7-[(5-amino-1,3,4-thiadiazol-2-yl)methoxy]-2H-chromen-2-one (4), 5-[(2-oxo-2H-chromen-7-yloxy)methyl]-1,3,4-thiadiazol-2(3H)-one (5), 2-[2-(2-oxo-2H-chromen-7-yloxy)acetyl]-N-phenylhydrazinecarbothioamide (7), 7-[(5 ...
Ahmed A Al-Amiery +2 more
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Does umbelliferone protect primary cortical neuron cells against glutamate excitotoxicity [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2021 Glutamate is the major excitatory neurotransmitter in the central nervous system. Excessive glutamate is known to cause excitotoxicity. Umbelliferone is a coumarin derivative compound and has anti-oxidant, anti-infl ammatory, and neuroprotective eff ects.
Alper Kürşat DEMİRKAYA +5 more
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Soil Effects on the Bioactivity of Hydroxycoumarins as Plant Allelochemicals
Plants, 2023 Soil plays a primary role in the activity of plant allelochemicals in natural and agricultural systems. In this work, we compared the phytotoxicity of three natural hydroxycoumarins (umbelliferone, esculetin, and scopoletin) to different model plant ...
Gracia Facenda +4 more
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Iraqi Journal of Pharmaceutical Sciences, 2021 The present investigation developed the ester prodrugs of Non-steroidal anti inflammatory drugs (NSAIDs), Mefenamic acid and Flurbiprofen by conjugating with the natural antioxidant, 4-methyl umbelliferone that resulted the formation of Mefenamic acid ...
NIJA B, Arun Rasheed, A Kottaimuthu
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Pharmaceuticals, 2023 Umbelliferone (UMB), known as 7-hydroxycoumarin, hydrangine, or skimmetine, is a naturally occurring coumarin in the plant kingdom, mainly from the Umbelliferae family that possesses a wide variety of pharmacological properties.
Anita Kornicka +3 more
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Renoprotective effect of umbelliferone in high-fat diet/streptozotocin-induced type 2 diabetic rats
Asian Pacific Journal of Tropical Biomedicine, 2020 Objective: To evaluate the renoprotective effect of umbelliferone in high-fat diet/streptozotocin-induced type 2 diabetic rats. Methods: We established a streptozotocin-induced type 2 diabetic model in male Wistar rats.
Jarinyaporn Naowaboot +2 more
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Challenges in the Heterologous Production of Furanocoumarins in Escherichia coli
Molecules, 2022 Coumarins and furanocoumarins are plant secondary metabolites with known biological activities. As they are present in low amounts in plants, their heterologous production emerged as a more sustainable and efficient approach to plant extraction. Although
Joana L. Rodrigues +2 more
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