Results 51 to 60 of about 288 (215)
Advanced Science, EarlyView.Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng +17 more
wiley +1 more source
Catastrophe optics theory unveils the localised wave aberration features that generate ghost images. [PDF]
Ophthalmic Physiol Opt, 2022 Barbero S +4 more
europepmc +1 more source
Stable umbilical points of a W-congruence
22 pages, 2 ...
Craizer, Marcos, Garcia, Ronaldo Alves
openaire +2 more sources
Advanced Science, EarlyView.A periosteum‐inspired Janus piezoelectric scaffold converts micromechanical forces into electrical signals and synergizes with controlled resveratrol release. This dual action reprograms endothelial metabolism, drives H‑type vessel formation, and restores bone–vessel coupling in diabetic bone defects.
Kai Wang, Kai Jiang
wiley +1 more source
Advanced Science, EarlyView.Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim +9 more
wiley +1 more source
Advanced Science, EarlyView.The iPRF‐MA/Alg‐NHS/Lut@EGCG (PGAE) double‐network hydrogel achieves durable wet adhesion in the oral environment. It simultaneously reprograms neutrophils from NETosis to phagocytosis for biofilm clearance, and activates the FAK‐RhoA‐YAP mechanotransduction pathway in gingival fibroblasts to drive extracellular matrix remodeling, thereby promoting ...
Sicong Ren +9 more
wiley +1 more source
Advanced Science, EarlyView.A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li +9 more
wiley +1 more source
Degenerate Umbilic Points of Analytic Surfaces
Umbilics are points of a surface embedded in three space where normal curvatures are independent of direction. The (in)famous Carathéodory Conjecture states that a compact simply connected embedded surface has at least two umbilic points. A counterexample to this conjecture would be a surface whose principal foliation has index two at a single umbilic.
openaire +2 more sources
An umbilical point on a non-real-analytic surface
Hiroshima Mathematical Journal, 2003 The index of an isolated umbilical point on a surface in three-dimensional Euclidean space is studied. The main attention is paid to the following index conjecture: the index of an isolated umbilical point is not more than one. This conjecture is motivated by studying constant mean curvature surfaces whose isolated umbilical points are always of ...
openaire +3 more sources
Advanced Science, EarlyView.This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian +10 more
wiley +1 more source