Results 101 to 110 of about 77,243 (300)

Effects of dietary intervention on diabetic nephropathy: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials

Frontiers in Endocrinology
ObjectiveTo evaluate the quality of evidence, potential biases, and validity of all available studies on dietary intervention and diabetic nephropathy (DN).MethodsWe conducted an umbrella review of existing meta-analyses of randomized controlled trials ...
Linli Cai, Yin Huang, Xingyuan Li, Dehong Cao, Dehong Cao, Fang Liu   +5 more
doaj   +1 more source

Through the lens of marketing authorization holders: experience in use of real‐world data and real‐world evidence in drug development and regulatory submissions in EU

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The aim of this study was to assess the general and product‐specific experiences of MAHs use of RWD/RWE in medicines development and in their regulatory submissions, and to explore organizational aspects of MAHs related to RWD/RWE. Methods An electronic survey was conducted, and information collected directly from MAHs.
Sini M. Eskola, Aleksandar Gigov, Hubertus G. M. Leufkens, Andrew Bate, Marie Louise De Bruin, Helga Gardarsdottir   +5 more
wiley   +1 more source

The effectiveness, implementation, and experiences of peer support approaches for mental health: a systematic umbrella review

BMC Medicine
Background Peer support for mental health is recommended across international policy guidance and provision. Our systematic umbrella review summarises evidence on the effectiveness, implementation, and experiences of paid peer support approaches for ...
Ruth E. Cooper, Katherine R. K. Saunders, Anna Greenburgh, Prisha Shah, Rebecca Appleton, Karen Machin, Tamar Jeynes, Phoebe Barnett, Sophie M. Allan, Jessica Griffiths, Ruth Stuart, Lizzie Mitchell, Beverley Chipp, Stephen Jeffreys, Brynmor Lloyd-Evans, Alan Simpson, Sonia Johnson   +16 more
doaj   +1 more source

Umbrella Branding and External Certification [PDF]

We study the interdependence of optimal tax and expenditure policies. An optimal policy requires that information on preferences is made available.
Hendrik Hakenes, Martin Peitz
core  

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Dietary protein and blood pressure: an umbrella review of systematic reviews and evaluation of the evidence [PDF]

INTRODUCTION: This umbrella review aimed to investigate the evidence of an effect of dietary intake of total protein, animal and plant protein on blood pressure (BP), and hypertension (PROSPERO: CRD42018082395).
Watzl, B., Louis, Sandrine, Kroke, A., Schutkowski, Alexandra, Siener, Roswitha, Siener, R., Zittermann, Armin, Louis, S., Egert, S., Nimptsch, K., Watzl, Bernhard, Lorkowski, S., Kroke, Anja, Amini, A.M., Ellinger, Sabine, Schwingshackl, Lukas, Schulze, Matthias B., Ellinger, S., Bischoff-Ferrari, Heike A., Schwingshackl, L., Buyken, Anette E., Nimptsch, Katharina Nimptsch, Bischoff-Ferrari, H.A., Buyken, A.E., Schmidt, A., Schutkowski, A., Stangl, Gabriele I., Haardt, Julia, Zittermann, A., Nimptsch, Katharina, Boeing, H., Haardt, J., Lorkowski, Stefan, Stangl, G.I., Boeing, Heiner, Schulze, M.B., Amini, Anna M., Schmidt, Annemarie, Egert, Sarah   +38 more
core   +1 more source

Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe

British Journal of Clinical Pharmacology, EarlyView.
Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis, Christine Leopold, Joyce M. Hoek, Raymond M. Schiffelers, Marie L. De Bruin   +4 more
wiley   +1 more source

Understanding exam access arrangements in practice: Challenges and opportunities

British Educational Research Journal, EarlyView.
Abstract Secondary students with specific learning difficulties (SpLD) often face challenges with academic tasks, particularly with high‐stakes examinations. Exam access arrangements (EAA) are provided as reasonable adjustments to reduce disadvantage for students with SpLD.
Catherine Antalek, Amelia Roberts, Emma Sumner   +2 more
wiley   +1 more source

Beyond standardisation, subjects and syllabi: How primary schools organise for arts richness in an era of curriculum reform

British Educational Research Journal, EarlyView.
Abstract As England embarks on its first comprehensive curriculum review in fifteen years, this paper offers critical insights from schools that sustained arts‐rich provision despite a policy landscape hostile to creative subjects. Drawing on data from the Researching Arts‐rich Primary Schools (RAPS) project—a mixed‐methods study of 76 arts‐rich ...
Pat Thomson, Christine Hall
wiley   +1 more source

CYTOTOXICITY OF ORTHODONTICS ALIGNERS: AN UMBRELLA REVIEW

Journal of Evidence-Based Dental Practice
This umbrella review aims to determine if clear aligners promote cytotoxic and estrogenic effects.The review was conducted in conformity with the PRISMA statement. A systematic search was carried out in March of 2025 in 5 databases (Medline through PubMed, Web of Science (all databases), Cochrane Library, Embase, and Epistemonikos).
CATARINA NUNES, BEATRIZ ORNELAS, CARLOS MIGUEL MARTO, ANABELA PAULA, MAFALDA LARANJO, CATARINA MESTRE, RAQUEL TRAVASSOS, INÊS FRANCISCO, FRANCISCO VALE   +8 more
openaire   +2 more sources