Results 121 to 130 of about 11,470,422 (277)

The VBHC big picture: an umbrella review

BMC Health Services Research
Value-Based Health Care (VBHC) aims to improve patient outcomes while optimising healthcare costs. Despite global interest, its adoption varies widely due to system-specific contexts and stakeholder dynamics. Challenges such as organisational inertia, inconsistent data, and limited evidence on patient-reported measures hinder widespread implementation ...
Ana Moreira, José Crispim
openaire   +2 more sources

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Potentialities and critical issues of liquid biopsy in clinical practice: An umbrella review

Translational Oncology
Background: Liquid biopsy (LB) is a laboratory test performed on a fluid sample aiming at analyzing molecular data derived from circulating cells and related entities, or from nucleic acids.
Nicola Veronese, Claudio Luchini, Stefano Ciriminna, Katia Spinelli, Santo Fruscione, Paola Mattiolo, Miriam Belluzzo, Veronica Messina, Lee Smith, Mario Barbagallo, Walter Mazzucco   +10 more
doaj   +1 more source

Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe

British Journal of Clinical Pharmacology, EarlyView.
Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis, Christine Leopold, Joyce M. Hoek, Raymond M. Schiffelers, Marie L. De Bruin   +4 more
wiley   +1 more source

Basket and umbrella trials in pediatric precision medicine: a systematic review of designs, opportunities, and challenges

BMC Medical Research Methodology
Background Personalized medicine, driven by genomic insights, has catalyzed the emergence of innovative clinical trial designs such as basket and umbrella trials.
Mohd Rashid Khan, Mariarita Stendardo, Silvia Bressan, Luca Vedovelli, Paola Berchialla, Ileana Baldi, Dario Gregori, Danila Azzolina   +7 more
doaj   +1 more source

Stroke and COVID-19: An Umbrella Review.

Archives of academic emergency medicine
Acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH) are among the acute cerebrovascular diseases (CVDs) that have been reported as a result of COVID-19. It will be a significant step forward if our research helps improve the compilation and analysis of existing data from other studies.The study is registered on PROSPERO with an ID of ...
Kavous Shahsavarinia, Nasim Hajipoor kashgsaray, Morteza Ghojazadeh, Zahra Falaki, Maryam Soleimanpour, Hassan Soleimanpour   +5 more
openaire   +3 more sources

Framing National Education in Hong Kong: A frame analysis of power dynamics in stakeholders' competing narratives

British Educational Research Journal, EarlyView.
Abstract This article examines how national education in Hong Kong functions as a contested arena in which state and non‐state actors struggle over the meaning of citizenship, identity and schooling. Using inductive frame analysis of 319 news articles (2020–2025) from five Chinese‐ and English‐language outlets, it identifies diagnostic, prognostic and ...
Jason Cong Lin
wiley   +1 more source

Powerful transformations: The experiences of higher education teaching staff who were first‐generation university students

British Educational Research Journal, EarlyView.
Abstract Historically, a university education has been seen primarily as a route for the middle classes to achieve professional qualifications while structural barriers have served to restrict entry to individuals from particular demographics. First‐generation students (FGS), often with low socio‐economic backgrounds, face multiple barriers to Higher ...
Helen Williams, Ellen‐Alyssa Gambles
wiley   +1 more source

Resolving the biome debate: ecological and palaeo‐data concur that the extensive tree‐limited grassy biomes of central and north‐western Madagascar are largely anthropogenic

Biological Reviews, EarlyView.
ABSTRACT For millennia, human activities have transformed ecosystems globally. Determining which landscapes are predominantly anthropogenic is crucial to conservation and habitat restoration. Madagascar, a critically‐threatened biodiversity hotspot, is a prominent example.
Grant S. Joseph, Sean Hixon, Colleen L. Seymour, Laurie R. Godfrey, Miguel Pedrono, Karen E. Samonds, Andrinajoro R. Rakotoarivelo, Brooke E. Crowley   +7 more
wiley   +1 more source

Default Effect in ESG Investment: When a Recommendation Goes a Long Way

Business Strategy and the Environment, EarlyView.
ABSTRACT Individual investors display a positive attitude toward ESG investments but typically fail to act upon it. We report results from a preregistered online experiment testing a default option on 1050 US investors examining the mechanisms driving the effectiveness of default options in promoting ESG investments.
Sai Sravanthi Ramadugula, R. Prasantha Kumar, Luc Meunier   +2 more
wiley   +1 more source