Results 161 to 170 of about 193,599 (260)

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, Volume 15, Issue 11, Page 1874-1885, November 2025.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, Volume 15, Issue 11, Page 1771-1788, November 2025.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, Volume 15, Issue 11, Page 1900-1912, November 2025.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Determining structures of RNA conformers using AFM and deep neural networks. [PDF]

Nature
Degenhardt MFS, Degenhardt HF, Bhandari YR, Lee YT, Ding J, Yu P, Heinz WF, Stagno JR, Schwieters CD, Watts NR, Wingfield PT, Rein A, Zhang J, Wang YX.   +13 more
europepmc   +1 more source

Automatic Derivation of LQN Performance Models from UML software models using Epsilon

, 2016
Mana Hassanzadeh Zargari
openalex   +2 more sources

A framework for verifying deadlock and nondeterminism in UML activity\n diagrams based on CSP [PDF]

, 2019
Lucas Ramos Costa Lima, Amaury Tavares, Sidney Nogueira   +2 more
openalex   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, Volume 15, Issue 11, Page 1886-1899, November 2025.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Formalized aspect-oriented misuse case for specifying crosscutting security threats and mitigations. [PDF]

PLoS One
Iqbal S, Faiz RB, Usman M, Rehman SU.
europepmc   +1 more source

Modeling of Online Clinical System using Object-Oriented Data through UML

, 2014
Suman KumarMishra, Vansh Raj Upadhyay
openalex   +1 more source

Automatic Generation and Optimization of Test Cases Using Genetic Algorithm with UML Diagram [PDF]

, 2019
Anju Bala, Rajender Singh Chhillar
openalex   +1 more source