Results 71 to 80 of about 60,497 (198)

Methodology Used to Create System Architecture for its in Slovakia

open access: yesAdvances in Electrical and Electronic Engineering, 2004
The paper deals with an object oriented approach proposed by the authors for creation of the ITS system architecture in the Slovak Republic and shows how a reference architecture can be created as s base for future more detailed architectures (models ...
Ales Janota, Jiri Zahradnik
doaj  

A Formal ORM-to -UML Mapping Algorithm [PDF]

open access: yes
The object-role model (ORM) data structure can be represented in the unified modeling language (UML) using the five fact encoding constructs: class attribute, association, association class, sub-class and the association qualifier.
Bollen,Peter
core  

Predicted microbiome‐associated metabolic pathways are linked to immune checkpoint modulation in chronic lymphocytic leukaemia

open access: yesBritish Journal of Haematology, EarlyView.
Summary Microbial metabolites are key regulators of host immunity, yet their functional impact in chronic lymphocytic leukaemia (CLL) remains unclear. Following up on our earlier observations of microbiome dysbiosis in CLL, we performed predictive metabolic profiling based on 16S ribosomal RNA (rRNA) sequencing of oral and stool samples collected from ...
Monika Szelest   +15 more
wiley   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz   +8 more
wiley   +1 more source

UML-B and Event-B: an integration of languages and tools

open access: yes, 2008
UML-B is a graphical front end for Event-B. It adds support for class-oriented modelling but retains the Event-B concept of a closed system characterized by families of spontaneous events.
Snook, Colin, Butler, Michael
core   +1 more source

Modelling of Signal - Level Crossing System

open access: yesAdvances in Electrical and Electronic Engineering, 2006
The author presents an object-oriented model of a railway level-crossing system created for the purpose of functional requirements specification. Unified Modelling Language (UML), version 1.4, which enables specification, visualisation, construction and ...
Daniel Novak
doaj  

A Unified Modeling Language-Based Design And Application For A Library Management Information System

open access: yesCybernetics and Information Technologies, 2014
This paper firstly introduces the main content of the Unified Modeling Language (UML) and proves that it can transmit information among the users, the developers, the designers and the managers efficiently, which improves their collaboration capabilities
Zheng Jianhu, Feng Yunqing, Zhao Yun
doaj   +1 more source

Atrial natriuretic peptide counteracts aldosterone secretion by preventing acute angiotensin II‐induced cAMP signalling

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar   +6 more
wiley   +1 more source

ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis

open access: yesThe FEBS Journal, EarlyView.
The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati   +4 more
wiley   +1 more source

Features of Introducing Agile Methodologies in the Software Development Process for Telecommunications Services

open access: yesСовременная конкуренция
The article discusses the features of the introduction of agile methodologies in the process of software development (hereinafter referred to as software) in the field of telecommunications services.
Alexander Yu. Anisimov   +3 more
doaj   +1 more source

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