Results 71 to 80 of about 187,911 (271)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Treatment options for vasomotor symptoms in menopause: focus on desvenlafaxine
International Journal of Women's Health, 2012 Elena M Umland, Laura FalconieriJefferson School of Pharmacy, Thomas Jefferson University, Philadelphia, PA, USAAbstract: Vasomotor symptoms (VMS), including hot flashes and night sweats, occur in as many as 68.5% of women as a result of menopause. While
Uml, EM, Falconieri L
doaj
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Translating standard process models to BPEL [PDF]
, 2006 Standardisation of languages in the field of business process management has long been an elusive goal. Recently though, consensus has built around one process implementation language, namely BPEL, and two fundamentally similar process modelling ...
B. Kiepuszewski +7 more
core +2 more sources
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
APLIKASI SYSTEM MANAGEMENT TASK DAN PENILAIAN KERJA (KPI) PADA PT INTISOFT MITRA SEJAHTERA
Ilkom Jurnal Ilmiah, 2018 The purpose of this study is to create an application that can provide benefits to PT Intisoft Mitra Sejahtera in managing the tickets delivered by the client, arrange program modification policies, and can see the assessment of the performance of ...
Maria Ocktaviani Zega +3 more
doaj +1 more source
Design Environments for Complex Systems [PDF]
, 2003 The paper describes an approach for modeling complex systems by hiding as much formal details as possible from the user, still allowing verification and simulation of the model.
Priami, Corrado
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
MDA-based ATL transformation to generate MVC 2 web models
, 2011 Development and maintenance of Web application is still a complex and error-prone process. We need integrated techniques and tool support for automated generation of Web systems and a ready prescription for easy maintenance.
Rahmouni, M'hamed
core +1 more source