Results 91 to 100 of about 60,497 (198)

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

The FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari, Budheswar Dehury, Rounak Roy, Radhakrishnan Periyasamy, Indrashis Bhattacharya, Mahesh Sahare, Srinivasan Vijayraghavan, Souvik Dey   +7 more
wiley   +1 more source

Derived classes as a basis for views in UML/OCL data models [PDF]

UML is the de facto standard language for analysis and design in object-oriented frameworks. Information systems, and in particular information systems based on databases and their applications, rely heavily on sound principles of analysis and design ...
Balsters, H.
core  

Állatmenhely webalkalmazás tervezése UML segítségével [PDF]

, 2009
A dolgozat témája az UML eszközeinek bemutatása egy webalkalmazás tervezésén keresztül ...
Deák, Zoltán
core  

Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron‐binding ridge

The FEBS Journal, EarlyView.
Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa, Ecir Uğur Küçüksille   +1 more
wiley   +1 more source

Animation of UML-B State-machines

Animation is important because it allows the modeller to validate that a model behaves as intended. Visualisation of animations assists the modeller in making this assessment.
Snook, Colin, Savicks, Vitaly, Butler, Michael   +2 more
core   +1 more source

Constraint Diagrams: A Step Beyond UML [PDF]

, 1999
The Unified Modeling Language (UML) is a set of notations for modelling object-oriented systems. It has become the de facto standard. Most of its notations are diagrammatic.
Howse, John, Gil, Joseph, Kent, Stuart
core   +1 more source

Contractionary Effects of Devaluation and the Balance Sheet Effect in a Macroeconomic Model With Heterogeneous Firms

Metroeconomica, EarlyView.
ABSTRACT We propose a demand‐led heterogeneous firm macroeconomic model to study the impact of an exchange rate devaluation on output and financial stability. We simulate the model and find that, in the presence of foreign debt, a devaluation can have contractionary effects.
Lucca Gustafson Rodrigues, Lílian Rolim, Laura Carvalho   +2 more
wiley   +1 more source

Model evolution and system evolution

Journal of Computer Science and Technology, 2000
In this paper we define an evolution mechanism with formal semantics using the metamodeling methodology [Geisler et al.98] based on dynamic logic. A remarkable feature of the metamodeling methodology is the ability to define the relation of intentional ...
Claudia Pons, Gabriel Alfredo Baum, Ralf-Detlef Kutsche   +2 more
doaj  

A Novel Distributed Sensor Network to Assess Wind Turbine Blade Acoustics for Structural Health Monitoring

Wind Energy, Volume 29, Issue 10, October 2026.
ABSTRACT To reduce the need for scheduled wind turbine blade inspections and large‐scale repairs, a novel distributed acoustic sensing system for monitoring the structural health of wind turbine blades is proposed. This integral passive monitoring system utilizes a sparse array of in‐blade multimodal sensors and a single blade‐external downtower sensor,
Connor Pozzi, Calvin Ng, Sage Lyon, Yan Luo, Christopher Niezrecki, Murat Inalpolat   +5 more
wiley   +1 more source

Therapeutic potential of a Bax inhibitor‐1/TMBIM6 antagonist (BIA) and its analogues in Aspergillus fumigatus‐induced asthma via dual targeting of AKT and epithelial‐derived inflammatory cytokines

British Journal of Pharmacology, Volume 183, Issue 19, Page 5975-5991, October 2026.
Background and Purpose Aspergillus fumigatus (A. fumigatus) exposure causes of severe allergic asthma, characterized by airway inflammation and epithelial dysfunction. TMBIM6 (Bax inhibitor‐1) has been implicated in airway epithelial stress responses and AKT signalling.
Young‐Jin Yu, Ahsan Ullah, Jisun Kim, Mehedi Hasan Bappi, Yerim Heo, Jin Hee Ahn, Hyun‐Kyoung Kim, Han‐Jung Chae   +7 more
wiley   +1 more source