Results 91 to 100 of about 5,243 (226)

Circadian rhythms of metabolite abundance in Drosophila are largely driven by time of feeding

open access: yesThe FEBS Journal, EarlyView.
Circadian clocks exist in the brain and peripheral tissues such as the Drosophila fat body. Single‐nuclei transcriptomics reveal that the fat body clock generates time‐of‐day differences in metabolic gene transcription, which may also be indirectly controlled by brain clocks.
Sumit Saurabh   +7 more
wiley   +1 more source

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

open access: yesThe FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari   +7 more
wiley   +1 more source

The General-Purpose Modeling, Analysis, and Implementation of Software Architectures

open access: yesHavacılık ve Uzay Teknolojileri Dergisi, 2020
In this paper, a new software modeling language called SAMP is proposed, which is inspired from UML and enables the general-purpose modeling of software architectures but at the same time promotes the multiple-viewpoints modeling, formal verification of ...
Mert Özkaya
doaj  

Contractionary Effects of Devaluation and the Balance Sheet Effect in a Macroeconomic Model With Heterogeneous Firms

open access: yesMetroeconomica, EarlyView.
ABSTRACT We propose a demand‐led heterogeneous firm macroeconomic model to study the impact of an exchange rate devaluation on output and financial stability. We simulate the model and find that, in the presence of foreign debt, a devaluation can have contractionary effects.
Lucca Gustafson Rodrigues   +2 more
wiley   +1 more source

A Context‐Aware Decision Support Framework for Scientific Experiment Configuration

open access: yesSoftware: Practice and Experience, Volume 56, Issue 9, Page 1100-1119, September 2026.
ABSTRACT Introduction Defining an experimental configuration is a complex decision problem for early‐stage researchers, who must map goals, constraints, and requirements onto datasets, algorithms, and parameter settings that directly affect experimental outcomes.
Pouriya Miri   +3 more
wiley   +1 more source

A systematic review of generative AI in education: Empirical insights from a human–AI interaction perspective

open access: yesBritish Journal of Educational Technology, Volume 57, Issue 5, Page 1221-1271, September 2026.
Abstract With the increasing application of GenAI in education, researchers and practitioners are paying more and more attention to its effectiveness and impact in teaching and learning. This can be evidenced by the increasing number of literature reviews on this topic published in recent years.
Zhiping Liang   +5 more
wiley   +1 more source

Exploring Disulfide Bridge as a Tool to Improve Pioglitazone’s Neuroprotective Potential: Toward the Development of Prolonged‐Acting MAO‐B/PPARγ Modulators

open access: yesChemMedChem, Volume 21, Issue 15, 14 August 2026.
Pioglitazone is an antidiabetic drug acting as a peroxisome proliferator‐activated receptor γ (PPARγ) agonist and later repositioned as a monoamine oxidase B (MAO‐B) inhibitor. Despite promising preclinical premises, it showed a lack of efficacy in clinical trials as a treatment for neurodegenerative diseases.
Filippo Basagni   +12 more
wiley   +1 more source

UML2SC: Herramienta para el diseño de sistemas electrónicos complejos utilizando los lenguajes UML y SystemC

open access: yesRevista Facultad de Ingeniería Universidad de Antioquia, 2009
En este artículo se presenta un proceso para la transformación de sistemas basados en hardware/software descritos mediante UML a código esqueleto SystemC. Se introduce la herramienta UML2SC, basada en librerías de Java, mediante la cual se puede realizar
Blanca Alicia Correa   +5 more
doaj  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, Volume 600, Issue 15, Page 2175-2192, August 2026.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, Volume 600, Issue 15, Page 2094-2107, August 2026.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

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