Results 111 to 120 of about 187,911 (271)

Modelling electronic service systems using UML [PDF]

, 2003
This paper presents a profile for modelling systems of electronic services using UML. Electronic services encapsulate business services, an organisational unit focused on delivering benefit to a consumer, to enhance communication, coordination and ...
Piccinelli, G., Skene, J., Stearns, M.
core  

Model‐Based Systems Engineering in Space Applications: A Comprehensive Literature Review

Systems Engineering, EarlyView.
ABSTRACT The growing complexity of space engineering is driving the demand to embrace the adoption of Model‐Based Systems Engineering (MBSE). Although the MBSE is well‐practiced in the space industry, the level of effort and need required to obtain the benefits of MBSE vastly differ across enterprises; this disparity presents a significant challenge to
Rehobot Bekele Buruso, Sara Himmiche, Taiwo Tejumola, Yeshirun Alemayehu, Bertrand Rose   +4 more
wiley   +1 more source

Extending SysML v2 for Safety ‐ Open‐Source Library for the System‐Theoretic Process Analysis

Systems Engineering, EarlyView.
ABSTRACT Safety challenges in automated transport systems create the need for a strong design and safety coupling. In this regard, the second version of the Systems Modeling Language (SysML v2) offers new integration opportunities with extensibility features such as libraries.
Alexander Ahlbrecht, Florian Wagner, Umut Durak   +2 more
wiley   +1 more source

Blockchain Ontologies: OCL and REA [PDF]

Unified Modeling Language (UML) of Object Management Group, along with Object Constraint Language (OCL), are considered as the best fit for blockchain ontology.
Sfetcu, Nicolae
core  

A formal theory of conceptual modeling universals [PDF]

, 2004
Conceptual Modeling is a discipline of great relevance to several areas in Computer Science. In a series of papers [1,2,3] we have been using the General Ontological Language (GOL) and its underlying upper level ontology, proposed in [4,5], to evaluate ...
Guizzardi, Giancarlo, Sinderen, Marten van, Wagner, Gerd   +2 more
core   +3 more sources

Modelling and Refinement in CODA

, 2013
This paper provides an overview of the CODA framework for modelling and refinement of component-based embedded systems. CODA is an extension of Event-B and UML-B and is supported by a plug-in for the Rodin toolset.
Butler, Michael, Colley, John, Edmunds, Andrew, Evans, Neil, Grant, Neil, Marshall, Helen, Snook, Colin   +6 more
core   +2 more sources

A systematic review of generative AI in education: Empirical insights from a human–AI interaction perspective

British Journal of Educational Technology, EarlyView.
Abstract With the increasing application of GenAI in education, researchers and practitioners are paying more and more attention to its effectiveness and impact in teaching and learning. This can be evidenced by the increasing number of literature reviews on this topic published in recent years.
Zhiping Liang, Kaixun Yang, Lele Sha, Dragan Gašević, Lixiang Yan, Guanliang Chen   +5 more
wiley   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin‐degrading enzyme, a new molecular vulnerability in multiple myeloma

British Journal of Pharmacology, EarlyView.
Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire, Rebecca Deprez‐Poulain, Damien Bosc, Florence Leroux, Valerie Landry, Sarah Ourabah, Morgane Tardy, Clara Maillard, Ronan Gealageas, Julie Dumont, Adrien Herledan, Sandrine Warenghem, Manon Cruette, Celine Lenglart, Alexandre Biela, Catherine Piveteau, Eva De Smedt, Catharina Muylaert, Wenguang Liang, Elvira Garcia De Paco, Elina Alaterre, Sara Ovejero, Nicolas Robert, Fabien Delahaye, Wei‐Jen Tang, Peter van Endert, Elke De Bruyne, Jérôme Moreaux, Benoit Deprez   +28 more
wiley   +1 more source

Derived classes as a basis for views in UML/OCL data models [PDF]

UML is the de facto standard language for analysis and design in object-oriented frameworks. Information systems, and in particular information systems based on databases and their applications, rely heavily on sound principles of analysis and design ...
Balsters, H.
core   +1 more source