Results 111 to 120 of about 5,243 (226)

When GUI‐Based Testing of Web Applications Meets Code Review

Software Testing, Verification and Reliability, Volume 36, Issue 5, August 2026.
Summary of our findings on practices, challenges, information needs and future improvements for code review of GUI‐based testing artefacts. ABSTRACT Code review is a well‐established practice to ensure code quality, identify potential bugs, promote knowledge sharing and maintain coding standards within a team or organization.
Andreas Bauer, Tomas Helmfridsson, Emil Alégroth, Georg‐Daniel Schwarz   +3 more
wiley   +1 more source

Flecainide binding dynamics in voltage‐gated sodium channels: A comparative isoform analysis of the state‐dependent block

British Journal of Pharmacology, Volume 183, Issue 15, Page 4145-4162, August 2026.
Background and Purpose Local anaesthetics and class I anti‐arrhythmic drugs block voltage‐gated Na+ channels, but the molecular basis for the isoform differences in drug sensitivity remains unclear. Understanding these mechanisms is essential for optimizing therapeutic efficacy and safety.
Tatsuo Munakata, Etsuko Kumada, Nao Katayama, Hiroki Nakagawa, Akihiko Sunami   +4 more
wiley   +1 more source

Targeting the noncatalytic activity of GSK3β modulates neuronal excitability in medium spiny neurons via Nav1.6 interactions

British Journal of Pharmacology, Volume 183, Issue 15, Page 4344-4363, August 2026.
Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh, Zahra Haghighijoo, Akanksha Gurtu, Nolan M. Dvorak, Timothy J. Baumgartner, Nana A. Goode, Jully Singh, Matteo Bernabucci, Adam T. Szafran, Michael J. Bolt, Michael A. Mancini, Natalie M. Dvorak, Marijn Lijffijt, Zhiqing Liu, Yu Xue, Alyssa K. Thomas, Alejandro Villasante‐Tezanos, Balaji Krishnan, Jia Zhou, Fernanda Laezza   +19 more
wiley   +1 more source

Agile Modeling with the UML

, 2004
14 pages, 8 figures, Radical Innovations of Software and Systems Engineering in the Future. 9th International Workshop, RISSEF 2002. Venice, Italy, October 2002. LNCS 2941. Springer Verlag 2004.
openaire   +2 more sources

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, Volume 183, Issue 16, Page 5082-5101, August 2026.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Automated project scheduling from UML sequence diagrams using OCR and critical path analysis. [PDF]

Sci Rep
Alyami A, Allahem H, Mostafa AM, Mahmood MA.   +3 more
europepmc   +1 more source

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

The FEBS Journal, Volume 293, Issue 15, Page 4489-4507, August 2026.
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova, Caroline M. Ferreira, Katrina P. Montales, Francisco Villalobos, Alexandra J. Brownstein, Rebeca Acín‐Pérez, Gabrielly S. Ferreira, Anthony E. Jones, Linsey Stiles, Ajit S. Divakaruni, Marc Liesa, Orian S. Shirihai, Marcus F. Oliveira   +12 more
wiley   +1 more source

Machine learning for microscopy data analytics targeting real-time optical characterization of semiconductor nanocrystals. [PDF]

Nat Commun
Mukherjee A, Reynaerts R, Pradhan B, Seth S, Rösch AT, Banerjee T, Chouhan L, Jin H, Sternemann C, Paulus M, Leoncino L, Mali KS, De Feyter S, Roeffaers MBJ, Meijer EW, Hofkens J, Debroye E.   +16 more
europepmc   +1 more source

UML for ABM

Journal of Artificial Societies and Social Simulation, 2012
openaire   +1 more source

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

The FEBS Journal, Volume 293, Issue 15, Page 4508-4532, August 2026.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump, Leja Perne, Špela Koren, Eva Jarc Jovičić, Nastja Feguš, Carina Pinto Kozmus, Michele Wölk, Kristyna Brejchova, Maria Fedorova, Ondrej Kuda, Toni Petan   +10 more
wiley   +1 more source