Results 121 to 130 of about 60,645 (326)

PLGA‐particle‐based vaccine induces SARS‐CoV‐2‐specific antibody and T‐cell responses

British Journal of Pharmacology, EarlyView.
A novel coronavirus disease 2019 (COVID‐19) vaccine encapsulating recombinant severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike receptor binding domain (RBD) with the double stranded RNA (dsRNA) analogue Riboxxim induces robust systemic and respiratory T‐ and B‐cell responses in mice.
Dennis Horvath, Katharina Inholz, Dennis Mink, Alicia Madel, Julia Koerner, Reinhold Horlacher, Michael Basler   +6 more
wiley   +1 more source

Applying UML : advanced application /

, 2004
An indispensible guide to applying UML in real world situations.Includes bibliographical references and index.Cover; Copyright Page; TOCContents; Preface; Who Should Read This Book?; What This Book Is Not; How Should You Use This Book?; Supplementary ...
Pooley, R. J., Wilcox, Pauline.
core  

A Service-Oriented UML Profile with Formal Support [PDF]

, 2009
Roberto Bruni, M. Hölzl, Nora Koch, Alberto Lluch Lafuente, Philip Mayer, Ugo Montanari, A. Sebastian Schroeder, Martin Wirsing   +7 more
openalex   +1 more source

The amino terminal domain of the human α7 nicotinic acetylcholine receptor subunit leads to the functional expression of human/insect receptors

British Journal of Pharmacology, EarlyView.
Human α7 receptors have been characterised in terms of pharmacological properties. Insertion of the N‐terminal domain of the human α7 subunit leads to honeybee and cockroach chimeric receptors activated by ACh and inhibited by α‐Bgt. Insertion of the human cys‐loop leads to cockroach chimeric receptors modulated by PNU.
Alison Cartereau, Chloé Veront, Alexandra Cremades, Priscilla Martin, Remi Gojard, Nicolas Galland, Emiliane Taillebois, Dieudonnée Togbé, Jean‐Yves Le Questel, Steeve H. Thany   +9 more
wiley   +1 more source

Flecainide binding dynamics in voltage‐gated sodium channels: A comparative isoform analysis of the state‐dependent block

British Journal of Pharmacology, EarlyView.
Background and Purpose Local anaesthetics and class I anti‐arrhythmic drugs block voltage‐gated Na+ channels, but the molecular basis for the isoform differences in drug sensitivity remains unclear. Understanding these mechanisms is essential for optimizing therapeutic efficacy and safety.
Tatsuo Munakata, Etsuko Kumada, Nao Katayama, Hiroki Nakagawa, Akihiko Sunami   +4 more
wiley   +1 more source

UML-B Survey Questionnaires and Responses

, 2007
This document contains the questionnaires and responses of the survey conducted on the UML-B method. The survey assessed the usability of the method, particularly the notation used, from the developers’ perspective.
Razali, R
core  

Targeting the noncatalytic activity of GSK3β modulates neuronal excitability in medium spiny neurons via Nav1.6 interactions

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh, Zahra Haghighijoo, Akanksha Gurtu, Nolan M. Dvorak, Timothy J. Baumgartner, Nana A. Goode, Jully Singh, Matteo Bernabucci, Adam T. Szafran, Michael J. Bolt, Michael A. Mancini, Natalie M. Dvorak, Marijn Lijffijt, Zhiqing Liu, Yu Xue, Alyssa K. Thomas, Alejandro Villasante‐Tezanos, Balaji Krishnan, Jia Zhou, Fernanda Laezza   +19 more
wiley   +1 more source

Experimental Comparison of the Comprehensibility of a UML-based Formal Specification versus a Textual One

, 2007
The primary objective of software specification is to promote understanding of the system properties between stakeholders. Specification comprehensibility is essential particularly during software validation and maintenance as it permits the ...
Michael R. Poppleton, Robert P Walters, Paul W Garratt, Razali, R, Poppleton, M. R., Walters, R. J., Garratt, P. W., Snook, C. F., Colin F. Snook, Rozilawati Razali   +9 more
core   +1 more source

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Specification language for automatа-based objects cooperation

Научно-технический вестник информационных технологий, механики и оптики
Automata-based programming is a programming paradigm that has been successfully used in the development of reactive systems, distributed control systems, and various mission-critical applications where the ability to verify the compliance of a real ...
F. A. Novikov, I. V. Afanasieva, L. N. Fedorchenko, T. A. Kharisova   +3 more
doaj   +1 more source