Results 81 to 90 of about 187,911 (271)

A thread-tag based semantics for sequence diagrams [PDF]

open access: yes, 2007
The sequence diagram is one of the most popular behaviour modelling languages which offers an intuitive and visual way of describing expected behaviour of object-oriented software.
Counsell, S, Dan, H, Hierons, RM
core   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Exploiting UMLS Semantics for Checking Semantic Consistency among UMLS concepts

open access: yes, 2010
Objectives: To quantify semantic inconsistency in UMLS concepts from the perspective of their hierarchical relations and to show through examples how semantically-inconsistent concepts can help reveal erroneous synonymy relations. Methods: Inconsistency is defined in reference to concepts from the UMLS Metathesaurus.
Erdogan, Halit   +2 more
openaire   +3 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

Methodology Used to Create System Architecture for its in Slovakia

open access: yesAdvances in Electrical and Electronic Engineering, 2004
The paper deals with an object oriented approach proposed by the authors for creation of the ITS system architecture in the Slovak Republic and shows how a reference architecture can be created as s base for future more detailed architectures (models ...
Ales Janota, Jiri Zahradnik
doaj  

Logics for Conceptual Data Modelling: A Review [PDF]

open access: yesTransactions on Graph Data and Knowledge
Information modelling for databases and object-oriented information systems avails of conceptual data modelling languages such as EER and UML Class Diagrams.
Fillottrani, Pablo R., Keet, C. Maria
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Estimation of Low-Cycle Fatigue Curves of High-Strength and Welded Steel 10CrNi3MoV [PDF]

open access: yes, 2019
In this work is tested applicability of the extended uniform material law for high-strength steel on 10CrNi3MoV steel and its weld. Predicted low-cycle fatigue curves differ significantly from the measurements. Despite the reported scientific effort to
Kráčalík, Michal
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

open access: yesFEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim   +11 more
wiley   +1 more source

Modelling of Signal - Level Crossing System

open access: yesAdvances in Electrical and Electronic Engineering, 2006
The author presents an object-oriented model of a railway level-crossing system created for the purpose of functional requirements specification. Unified Modelling Language (UML), version 1.4, which enables specification, visualisation, construction and ...
Daniel Novak
doaj  

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