Results 101 to 110 of about 1,008 (206)

Flecainide binding dynamics in voltage‐gated sodium channels: A comparative isoform analysis of the state‐dependent block

British Journal of Pharmacology, Volume 183, Issue 15, Page 4145-4162, August 2026.
Background and Purpose Local anaesthetics and class I anti‐arrhythmic drugs block voltage‐gated Na+ channels, but the molecular basis for the isoform differences in drug sensitivity remains unclear. Understanding these mechanisms is essential for optimizing therapeutic efficacy and safety.
Tatsuo Munakata, Etsuko Kumada, Nao Katayama, Hiroki Nakagawa, Akihiko Sunami   +4 more
wiley   +1 more source

A Timed-Permission Access Control Profile Within MARTE

IEEE Access
Android applications often interact through inter-component communication (ICC), which can be exploited for privilege escalation attacks. Traditional permission-based access control (PBAC) mechanisms lack the ability to express temporal constraints ...
Xinwen Hu
doaj   +1 more source

Targeting the noncatalytic activity of GSK3β modulates neuronal excitability in medium spiny neurons via Nav1.6 interactions

British Journal of Pharmacology, Volume 183, Issue 15, Page 4344-4363, August 2026.
Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh, Zahra Haghighijoo, Akanksha Gurtu, Nolan M. Dvorak, Timothy J. Baumgartner, Nana A. Goode, Jully Singh, Matteo Bernabucci, Adam T. Szafran, Michael J. Bolt, Michael A. Mancini, Natalie M. Dvorak, Marijn Lijffijt, Zhiqing Liu, Yu Xue, Alyssa K. Thomas, Alejandro Villasante‐Tezanos, Balaji Krishnan, Jia Zhou, Fernanda Laezza   +19 more
wiley   +1 more source

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, Volume 183, Issue 16, Page 5082-5101, August 2026.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Generating Accessible Webpages from Models

Computers
Despite significant efforts to promote web accessibility through the adoption of various standards and tools, the web remains inaccessible to many users.
Karla Ordoñez-Briceño, José R. Hilera, Luis De-Marcos, Rodrigo Saraguro-Bravo   +3 more
doaj   +1 more source

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

The FEBS Journal, Volume 293, Issue 15, Page 4508-4532, August 2026.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump, Leja Perne, Špela Koren, Eva Jarc Jovičić, Nastja Feguš, Carina Pinto Kozmus, Michele Wölk, Kristyna Brejchova, Maria Fedorova, Ondrej Kuda, Toni Petan   +10 more
wiley   +1 more source

A new branch of mammalian vitamin B6 metabolism: AKR1C‐mediated conversion of pyridoxal to pyridoxine and 4‐pyridoxolactone

The FEBS Journal, Volume 293, Issue 16, Page 4841-4859, August 2026.
Pyridoxal 5'‐phosphate (PLP), the coenzyme form of vitamin B6, is essential for amino acid metabolism. In mammals, PLP homeostasis relies on salvage enzymes, yet key metabolic branches remain undefined. We identify AKR1C isozymes as previously undescribed contributors that convert pyridoxal into pyridoxine or 4‐pyridoxolactone through reductase and ...
Nayu Kito, Yasuyuki Kitaura, Kyoka Iino, Kazuya Toriumi, Hyunah Noh, Naoya Ogawa, Makoto Arai, Hisashi Hemmi, Tomokazu Ito   +8 more
wiley   +1 more source

Untangling Mephedrone‐Induced Social Reward in Rats—The Involvement of Oxytocin and Vasopressin V1A Receptors

Genes, Brain and Behavior, Volume 25, Issue 4, August 2026.
Social context alters the neurochemical and neuropeptidergic mechanisms of mephedrone reward, revealing a dual regulation by monoamines and oxytocin/vasopressin signaling in brain regions critical for reinforcement. ABSTRACT The rewarding effects of psychostimulants are strongly influenced by social context, yet the underlying neurochemical and ...
Olga Wronikowska‐Denysiuk, Łukasz Kurach, Radosław Mlak, Dominika Przygodzka, Tymoteusz Słowik, Barbara Budzyńska   +5 more
wiley   +1 more source

Modeling and verification of authentication threats mitigation in aspect-oriented mal sequence woven model. [PDF]

PLoS One, 2022
Ullah U, Faiz RB, Haleem M.
europepmc   +1 more source

Machine learning for microscopy data analytics targeting real-time optical characterization of semiconductor nanocrystals. [PDF]

Nat Commun
Mukherjee A, Reynaerts R, Pradhan B, Seth S, Rösch AT, Banerjee T, Chouhan L, Jin H, Sternemann C, Paulus M, Leoncino L, Mali KS, De Feyter S, Roeffaers MBJ, Meijer EW, Hofkens J, Debroye E.   +16 more
europepmc   +1 more source